Search Results - "Packer MJ"

Discovery of AZD9750, an Orally Bioavailable Androgen Receptor Degrader for the Treatment of Prostate Cancer.

Authors: Scott JS Evans L Astles PC et al.

Source: Journal of medicinal chemistry [J Med Chem] 2026 Feb 12; Vol. 69 (3), pp. 3209-3232. Date of Electronic Publication: 2026 Jan 29.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

AZ14289671 is a highly selective and blood-brain barrier penetrant irreversible TKI that targets EGFRExon20 insertions.

Authors: Swaih AM Talbot S Savoca A et al.

Source: Cell reports. Medicine [Cell Rep Med] 2025 Sep 16; Vol. 6 (9), pp. 102305. Date of Electronic Publication: 2025 Aug 25.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101766894 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2666-3791 (Electronic) Linking ISSN: 26663791 NLM ISO Abbreviation: Cell Rep Med Subsets: MEDLINE

Effect of a Collar and Harness on Intraocular Pressure and Respiration Rate of Brachycephalic and Dolichocephalic Dogs.

Authors: Bailey ME Packer MJ Wills AP

Source: Veterinary medicine and science [Vet Med Sci] 2025 May; Vol. 11 (3), pp. e70384.

Publication Type: Journal Article

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 101678837 Publication Model: Print Cited Medium: Internet ISSN: 2053-1095 (Electronic) Linking ISSN: 20531095 NLM ISO Abbreviation: Vet Med Sci Subsets: MEDLINE

Highly Optimized CNS Penetrant Inhibitors of EGFR Exon20 Insertion Mutations.

Authors: McCoull W Thomson C Braybrooke E et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Feb 13; Vol. 68 (3), pp. 3700-3748. Date of Electronic Publication: 2025 Jan 27.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.

Authors: Johannes JW Balazs AYS Barratt D et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Dec 26; Vol. 67 (24), pp. 21717-21728. Date of Electronic Publication: 2024 Dec 10.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Bifocal stance theory, the transmission metaphor, and institutional reality.

Authors: Packer MJ Cole M

Source: The Behavioral and brain sciences [Behav Brain Sci] 2022 Nov 10; Vol. 45, pp. e264. Date of Electronic Publication: 2022 Nov 10.

Publication Type: Journal Article

Journal Info: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 7808666 Publication Model: Electronic Cited Medium: Internet ISSN: 1469-1825 (Electronic) Linking ISSN: 0140525X NLM ISO Abbreviation: Behav Brain Sci Subsets: MEDLINE

Optimization of Potent, Efficacious, Selective and Blood-Brain Barrier Penetrating Inhibitors Targeting EGFR Exon20 Insertion Mutations.

Authors: Thomson C Braybrooke E Colclough N et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Sep 28. Date of Electronic Publication: 2024 Sep 28.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of a Series of Orally Bioavailable Androgen Receptor Degraders for the Treatment of Prostate Cancer.

Authors: Bagal SK Astles PC Diène C et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Jul 25; Vol. 67 (14), pp. 11732-11750. Date of Electronic Publication: 2024 Jul 11.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Characterisation of high throughput screening outputs for small molecule degrader discovery.

Authors: Bell LE Bardelle C Packer MJ et al.

Source: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2024 Jul; Vol. 29 (5), pp. 100162. Date of Electronic Publication: 2024 May 24.

Publication Type: Journal Article

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.

Authors: Thomson C Barton P Braybrooke E et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Jun 13; Vol. 67 (11), pp. 8988-9027. Date of Electronic Publication: 2024 May 21.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery and characterisation of quinazolines and 8-Azaquinazolines as NLRP3 agonists with oral bioavailability in mice.

Authors: O' Donovan DH Baker D Ciotta G et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2023 Nov 15; Vol. 96, pp. 129518. Date of Electronic Publication: 2023 Oct 12.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.

Authors: Banks E Grondine M Bhavsar D et al.

Source: Science translational medicine [Sci Transl Med] 2020 Apr 29; Vol. 12 (541).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia.

Authors: Tron AE Belmonte MA Adam A et al.

Source: Nature communications [Nat Commun] 2018 Dec 17; Vol. 9 (1), pp. 5341. Date of Electronic Publication: 2018 Dec 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Grouping concentration response curves by features of their shape to aid rapid and consistent analysis of large data sets in high throughput screens.

Authors: Davies G Vincent J Packer MJ et al.

Source: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2022 Jun; Vol. 27 (4), pp. 272-277. Date of Electronic Publication: 2021 Dec 04.

Publication Type: Journal Article

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

NMR Molecular Replacement Provides New Insights into Binding Modes to Bromodomains of BRD4 and TRIM24.

Authors: Torres F Walser R Kaderli J et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Apr 14; Vol. 65 (7), pp. 5565-5574. Date of Electronic Publication: 2022 Mar 31.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.

Authors: Johannes JW Balazs A Barratt D et al.

Source: Journal of medicinal chemistry [J Med Chem] 2021 Oct 14; Vol. 64 (19), pp. 14498-14512. Date of Electronic Publication: 2021 Sep 27.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Predicting the relative binding affinity of mineralocorticoid receptor antagonists by density functional methods.

Authors: Roos K Hogner A Ogg D et al.

Source: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2015 Dec; Vol. 29 (12), pp. 1109-22. Date of Electronic Publication: 2015 Nov 16.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 8710425 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4951 (Electronic) Linking ISSN: 0920654X NLM ISO Abbreviation: J Comput Aided Mol Des Subsets: MEDLINE

Nuclear magnetic resonance free ligand conformations and atomic resolution dynamics.

Authors: Balazs AYS Davies NL Longmire D et al.

Source: Magnetic resonance (Gottingen, Germany) [Magn Reson (Gott)] 2021 Jun 23; Vol. 2 (1), pp. 489-498. Date of Electronic Publication: 2021 Jun 23 (Print Publication: 2021).

Publication Type: Journal Article

Journal Info: Publisher: Copernicus Publications Country of Publication: Germany NLM ID: 101775538 Publication Model: eCollection Cited Medium: Internet ISSN: 2699-0016 (Electronic) Linking ISSN: 26990016 NLM ISO Abbreviation: Magn Reson (Gott) Subsets: PubMed not MEDLINE

Free energy perturbation in the design of EED ligands as inhibitors of polycomb repressive complex 2 (PRC2) methyltransferase.

Authors: O' Donovan DH Gregson C Packer MJ et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2021 May 01; Vol. 39, pp. 127904. Date of Electronic Publication: 2021 Mar 06.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Correction to "Free Ligand 1D NMR Conformational Signatures To Enhance Structure Based Drug Design of a Mcl-1 Inhibitor (AZD5991) and Other Synthetic Macrocycles".

Authors: Balazs AYS Carbajo RJ Davies NL et al.

Source: Journal of medicinal chemistry [J Med Chem] 2021 Mar 11; Vol. 64 (5), pp. 2849. Date of Electronic Publication: 2021 Mar 01.

Publication Type: Published Erratum

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE; PubMed not MEDLINE