Search Results - "Pascal JM"

PARP1 and PARylation facilitate transcription-coupled DNA repair by stabilizing the CSB-RNAPII complex.

Authors: Robu M Shah RG van den Heuvel D et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Nov 26; Vol. 53 (22).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

PARP4 ADP-ribosylates PIDD1 to complete a phospho/SUMO/PAR-ylation cascade that orchestrates PIDDosome assembly.

Authors: Shah RB Li Y Person A et al.

Source: Science advances [Sci Adv] 2026 May; Vol. 12 (18), pp. eadz9284. Date of Electronic Publication: 2026 Apr 29.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13.

Authors: Cheng SJ Gafaar T Kuttiyatveetil JRA et al.

Source: Nature communications [Nat Commun] 2025 Jan 13; Vol. 16 (1), pp. 621. Date of Electronic Publication: 2025 Jan 13.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation.

Authors: Sverzhinsky A Xue H Langelier MF et al.

Source: Nature communications [Nat Commun] 2026 Feb 16; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 16.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

PARP enzyme synthesis of protein-free poly(ADP-ribose): Implications for DNA damage signaling and repair.

Authors: Langelier MF Pascal JM

Source: DNA repair [DNA Repair (Amst)] 2025 Oct; Vol. 154, pp. 103898. Date of Electronic Publication: 2025 Sep 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-7856 (Electronic) Linking ISSN: 15687856 NLM ISO Abbreviation: DNA Repair (Amst) Subsets: MEDLINE

Novel modifications of PARP inhibitor veliparib increase PARP1 binding to DNA breaks.

Authors: Velagapudi UK Rouleau-Turcotte É Billur R et al.

Source: The Biochemical journal [Biochem J] 2024 Mar 20; Vol. 481 (6), pp. 437-460.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

Structural and biochemical analysis of the PARP1-homology region of PARP4/vault PARP.

Authors: Frigon L Pascal JM

Source: Nucleic acids research [Nucleic Acids Res] 2023 Dec 11; Vol. 51 (22), pp. 12492-12507.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Crystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4.

Authors: Frigon L Pascal JM

Source: The Journal of biological chemistry [J Biol Chem] 2025 Jun; Vol. 301 (6), pp. 110277. Date of Electronic Publication: 2025 May 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

A PARP2 active site helix melts to permit DNA damage-induced enzymatic activation.

Authors: Smith-Pillet ES Billur R Langelier MF et al.

Source: Molecular cell [Mol Cell] 2025 Mar 06; Vol. 85 (5), pp. 865-876.e4. Date of Electronic Publication: 2025 Jan 30.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

PARP1 associates with R-loops to promote their resolution and genome stability.

Authors: Laspata N Kaur P Mersaoui SY et al.

Source: Nucleic acids research [Nucleic Acids Res] 2023 Mar 21; Vol. 51 (5), pp. 2215-2237.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

PARP enzyme de novo synthesis of protein-free poly(ADP-ribose).

Authors: Langelier MF Mirhasan M Gilbert K et al.

Source: Molecular cell [Mol Cell] 2024 Dec 19; Vol. 84 (24), pp. 4758-4773.e6. Date of Electronic Publication: 2024 Nov 12.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Authors: Valerie NCK Sanjiv K Mortusewicz O et al.

Source: Nature communications [Nat Commun] 2024 Dec 06; Vol. 15 (1), pp. 10347. Date of Electronic Publication: 2024 Dec 06.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.

Authors: Langelier MF Billur R Sverzhinsky A et al.

Source: Nature communications [Nat Commun] 2021 Nov 18; Vol. 12 (1), pp. 6675. Date of Electronic Publication: 2021 Nov 18.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Young adults' reasoning for involving a parent in a genomic decision-making research study.

Authors: Pascal JM McGowan ML Blumling AA et al.

Source: Journal of genetic counseling [J Genet Couns] 2024 Jun; Vol. 33 (3), pp. 653-665. Date of Electronic Publication: 2023 Aug 26.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 9206865 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-3599 (Electronic) Linking ISSN: 10597700 NLM ISO Abbreviation: J Genet Couns Subsets: MEDLINE

A PARP2-specific active site α-helix melts to permit DNA damage-induced enzymatic activation.

Authors: Smith-Pillet ES Billur R Langelier MF et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2024 May 20. Date of Electronic Publication: 2024 May 20.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

PARylation prevents the proteasomal degradation of topoisomerase I DNA-protein crosslinks and induces their deubiquitylation.

Authors: Sun Y Chen J Huang SN et al.

Source: Nature communications [Nat Commun] 2021 Aug 18; Vol. 12 (1), pp. 5010. Date of Electronic Publication: 2021 Aug 18.

Publication Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.

Authors: Ogden TEH Yang JC Schimpl M et al.

Source: Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 2266-2288.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

An atypical BRCT-BRCT interaction with the XRCC1 scaffold protein compacts human DNA Ligase IIIα within a flexible DNA repair complex.

Authors: Hammel M Rashid I Sverzhinsky A et al.

Source: Nucleic acids research [Nucleic Acids Res] 2021 Jan 11; Vol. 49 (1), pp. 306-321.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Clinical PARP inhibitors do not abrogate PARP1 exchange at DNA damage sites in vivo.

Authors: Shao Z Lee BJ Rouleau-Turcotte É et al.

Source: Nucleic acids research [Nucleic Acids Res] 2020 Sep 25; Vol. 48 (17), pp. 9694-9709.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

ADP-ribose contributions to genome stability and PARP enzyme trapping on sites of DNA damage; paradigm shifts for a coming-of-age modification.

Authors: Rouleau-Turcotte É Pascal JM

Source: The Journal of biological chemistry [J Biol Chem] 2023 Dec; Vol. 299 (12), pp. 105397. Date of Electronic Publication: 2023 Oct 28.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE