Search Results - "Pascal JM"

PARP-2 catalytic activity drives replication-ICL repair in an allele-specific manner during germline development.

Authors: Ren, Xiaojing Hu, Anna Liu, Zifei et al.

Source: PLoS Genetics. 3/5/2026, Vol. 22 Issue 3, p1-26. 26p.

Cooperative molecular interaction networks govern PARP1 inhibitor selectivity and binding affinity.

Authors: Feito, Alejandro DeMoya‐Valenzuela, Natàlia Privat, Cristian et al.

Source: PLoS Computational Biology. 5/26/2026, Vol. 22 Issue 5, p1-21. 21p.

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Regulation of stress granule maturation and dynamics by poly(ADP-ribose) interaction with PARP13.

Authors: Cheng SJ Gafaar T Kuttiyatveetil JRA et al.

Source: Nature communications [Nat Commun] 2025 Jan 13; Vol. 16 (1), pp. 621. Date of Electronic Publication: 2025 Jan 13.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation.

Authors: Sverzhinsky A Xue H Langelier MF et al.

Source: Nature communications [Nat Commun] 2026 Feb 16; Vol. 17 (1). Date of Electronic Publication: 2026 Feb 16.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

PARP enzyme synthesis of protein-free poly(ADP-ribose): Implications for DNA damage signaling and repair.

Authors: Langelier MF Pascal JM

Source: DNA repair [DNA Repair (Amst)] 2025 Oct; Vol. 154, pp. 103898. Date of Electronic Publication: 2025 Sep 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101139138 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1568-7856 (Electronic) Linking ISSN: 15687856 NLM ISO Abbreviation: DNA Repair (Amst) Subsets: MEDLINE

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM.

Authors: Valerie NCK Sanjiv K Mortusewicz O et al.

Source: Nature communications [Nat Commun] 2024 Dec 06; Vol. 15 (1), pp. 10347. Date of Electronic Publication: 2024 Dec 06.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Addition of PARP1-inhibition enhances chemoradiotherapy and thermoradiotherapy when treating cervical cancer in an in vivo mouse model.

Authors: IJff, Marloes Mei, Xionge Scutigliani, Enzo M. et al.

Source: International Journal of Hyperthermia. Dec2025, Vol. 42 Issue 1, p1-12. 12p.

Cancer-associated TRF1 mutations alter PARP1 interaction dynamics: an in silico study.

Authors: Mishra A Patel TN

Source: Mammalian genome : official journal of the International Mammalian Genome Society [Mamm Genome] 2026 Mar 14; Vol. 37 (1). Date of Electronic Publication: 2026 Mar 14.

Publication Type: Journal Article

Journal Info: Publisher: Springer-Verlag Country of Publication: United States NLM ID: 9100916 Publication Model: Electronic Cited Medium: Internet ISSN: 1432-1777 (Electronic) Linking ISSN: 09388990 NLM ISO Abbreviation: Mamm Genome Subsets: MEDLINE

Crystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4.

Authors: Frigon L Pascal JM

Source: The Journal of biological chemistry [J Biol Chem] 2025 Jun; Vol. 301 (6), pp. 110277. Date of Electronic Publication: 2025 May 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Comprehensive metabolomic profiling of Egyptian Salvia species reveals promising leads for chemopreventive and anti-inflammatory drug development: In vitro and In silico study.

Authors: Hamed, Ahmed R. Ali, Sherin K. Abdel-Halim, Sally A. et al.

Source: Scientific Reports. 6/9/2026, Vol. 16 Issue 1, p1-27. 27p.

The ENST00000539930 transcript predicts sensitivity to PARP inhibitors and clinical prognosis in cancers.

Authors: Xu, Chi Li, Cong Wang, Wenna et al.

Source: Oncologie (De Gruyter). Nov2025, Vol. 27 Issue 6, p991-1005. 15p.

The first and second zinc finger domains from Poly-ADP-ribose polymerase 1 (PARP1) are modified by hydrogen sulfide.

Authors: Williams AJ Michel SLJ

Source: Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry [J Biol Inorg Chem] 2026 Jun; Vol. 31 (4), pp. 279-291. Date of Electronic Publication: 2026 May 22.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 9616326 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1327 (Electronic) Linking ISSN: 09498257 NLM ISO Abbreviation: J Biol Inorg Chem Subsets: MEDLINE

ADP‐ribosyltransferases, an update on function and nomenclature.

Authors: Lüscher, Bernhard Ahel, Ivan Altmeyer, Matthias et al.

Source: FEBS Journal. Dec2022, Vol. 289 Issue 23, p7399-7410. 12p.

PARG inhibition reduces ssDNA levels and limits RPA loading upon replication fork collapse.

Authors: Mihuț A Ghosh D Kószó A et al.

Source: EMBO reports [EMBO Rep] 2026 Jul 04. Date of Electronic Publication: 2026 Jul 04.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

Radiosensitizing effect of astaxanthin on radiation-induced cytotoxicity in breast cancer cells.

Authors: Al-Awady B Osman AM Hanna D et al.

Source: Journal of the Egyptian National Cancer Institute [J Egypt Natl Canc Inst] 2026 Jun 08; Vol. 38 (1). Date of Electronic Publication: 2026 Jun 08.

Publication Type: Journal Article

Journal Info: Publisher: SpringerOpen Country of Publication: England NLM ID: 9424566 Publication Model: Electronic Cited Medium: Internet ISSN: 2589-0409 (Electronic) Linking ISSN: 11100362 NLM ISO Abbreviation: J Egypt Natl Canc Inst Subsets: MEDLINE

Polymerase face-off: emerging concepts in transcription-replication coordination.

Authors: Uruci S Lalonde M Luijsterburg MS et al.

Source: EMBO reports [EMBO Rep] 2026 Jun; Vol. 27 (12), pp. 3157-3172. Date of Electronic Publication: 2026 May 15.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

A CHK1-mediated phosphorylation switch suppresses human Topoisomerase 1-associated genomic instability.

Authors: Guha Majumdar A Chauhan N Gupta P et al.

Source: The EMBO journal [EMBO J] 2026 Jun; Vol. 45 (12), pp. 4220-4256. Date of Electronic Publication: 2026 May 13.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8208664 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1460-2075 (Electronic) Linking ISSN: 02614189 NLM ISO Abbreviation: EMBO J Subsets: MEDLINE

Development and evaluation of a ^99mTc-labeled olaparib analog for PARP imaging.

Authors: Xu, Wei Yan, Junjie Zhong, Xinlin et al.

Source: EJNMMI Radiopharmacy & Chemistry. 7/22/2025, Vol. 10 Issue 1, p1-17. 17p.

Enhanced tumor suppression in patient-derived temozolomide-resistant glioblastoma cells using a combination treatment of Olaparib and FK866.

Authors: Sha, Xiaowei Li, Jiaqian Fang, Yunlong et al.

Source: BMC Cancer. 7/15/2025, Vol. 25 Issue 1, p1-17. 17p.