Search Results - "Perryman AL"

Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.

Authors: Bubenik M Mader P Orlicky S et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Jan 07; Vol. 17 (2), pp. 433-440. Date of Electronic Publication: 2026 Jan 07 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

The Discovery of RP-2119: A Potent, Selective, and Orally Bioavailable Polθ ATPase Inhibitor.

Authors: Mochirian P Papp R Mathieu MC et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Sep 25; Vol. 68 (18), pp. 19726-19745. Date of Electronic Publication: 2025 Sep 08.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of RP-1664: A First-in-Class Orally Bioavailable, Selective PLK4 Inhibitor.

Authors: Vallée F Casás-Selves M Bubenik M et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Jun 12; Vol. 68 (11), pp. 10631-10647. Date of Electronic Publication: 2025 May 16.

Publication Type: Clinical Trial, Phase I; Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Identification and Biosynthesis of an N-Glucuronide Metabolite of Camonsertib.

Authors: Papp R Trimble L Fretland AJ et al.

Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2024 Feb 20; Vol. 52 (5). Date of Electronic Publication: 2024 Feb 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

Machine Learning Platform to Discover Novel Growth Inhibitors of Neisseria gonorrhoeae.

Authors: Pereira JC Daher SS Zorn KM et al.

Source: Pharmaceutical research [Pharm Res] 2020 Jul 13; Vol. 37 (7), pp. 141. Date of Electronic Publication: 2020 Jul 13.

Publication Type: Journal Article

Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika.

Authors: Mottin M de Paula Sousa BK de Moraes Roso Mesquita NC et al.

Source: Journal of chemical information and modeling [J Chem Inf Model] 2022 Dec 26; Vol. 62 (24), pp. 6825-6843. Date of Electronic Publication: 2022 Oct 14.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101230060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1549-960X (Electronic) Linking ISSN: 15499596 NLM ISO Abbreviation: J Chem Inf Model Subsets: MEDLINE

Identification of RP-6685, an Orally Bioavailable Compound that Inhibits the DNA Polymerase Activity of Polθ.

Authors: Bubenik M Mader P Mochirian P et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Oct 13; Vol. 65 (19), pp. 13198-13215. Date of Electronic Publication: 2022 Sep 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.

Authors: Szychowski J Papp R Dietrich E et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Aug 11; Vol. 65 (15), pp. 10251-10284. Date of Electronic Publication: 2022 Jul 26.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Naïve Bayesian Models for Vero Cell Cytotoxicity.

Authors: Perryman AL Patel JS Russo R et al.

Source: Pharmaceutical research [Pharm Res] 2018 Jun 29; Vol. 35 (9), pp. 170. Date of Electronic Publication: 2018 Jun 29.

Publication Type: Journal Article

Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

Rickettsia Aglow: A Fluorescence Assay and Machine Learning Model to Identify Inhibitors of Intracellular Infection.

Authors: Lemenze A Mittal N Perryman AL et al.

Source: ACS infectious diseases [ACS Infect Dis] 2022 Jul 08; Vol. 8 (7), pp. 1280-1290. Date of Electronic Publication: 2022 Jun 24.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Bayesian Modeling and Intrabacterial Drug Metabolism Applied to Drug-Resistant Staphylococcus aureus.

Authors: Patel JS Norambuena J Al-Tameemi H et al.

Source: ACS infectious diseases [ACS Infect Dis] 2021 Aug 13; Vol. 7 (8), pp. 2508-2521. Date of Electronic Publication: 2021 Aug 03.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery.

Authors: Ekins S Perryman AL Horta Andrade C

Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2016 Oct 20; Vol. 10 (10), pp. e0005023. Date of Electronic Publication: 2016 Oct 20 (Print Publication: 2016).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE

Predicting Mouse Liver Microsomal Stability with "Pruned" Machine Learning Models and Public Data.

Authors: Perryman AL Stratton TP Ekins S et al.

Source: Pharmaceutical research [Pharm Res] 2016 Feb; Vol. 33 (2), pp. 433-49. Date of Electronic Publication: 2015 Sep 28.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Kluwer Academic/Plenum Publishers Country of Publication: United States NLM ID: 8406521 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-904X (Electronic) Linking ISSN: 07248741 NLM ISO Abbreviation: Pharm Res Subsets: MEDLINE

Correction to "Comparing and Validating Machine Learning Models for Mycobacterium tuberculosis Drug Discovery".

Authors: Lane T Russo DP Zorn KM et al.

Source: Molecular pharmaceutics [Mol Pharm] 2021 Jul 05; Vol. 18 (7), pp. 2833. Date of Electronic Publication: 2021 Jun 17.

Publication Type: Published Erratum

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101197791 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1543-8392 (Electronic) Linking ISSN: 15438384 NLM ISO Abbreviation: Mol Pharm Subsets: MEDLINE; PubMed not MEDLINE

Biological evaluation of potent triclosan-derived inhibitors of the enoyl-acyl carrier protein reductase InhA in drug-sensitive and drug-resistant strains of Mycobacterium tuberculosis.

Authors: Stec J Vilchèze C Lun S et al.

Source: ChemMedChem [ChemMedChem] 2014 Nov; Vol. 9 (11), pp. 2528-37. Date of Electronic Publication: 2014 Aug 27.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Identification of a novel drug lead that inhibits HCV infection and cell-to-cell transmission by targeting the HCV E2 glycoprotein.

Authors: Al Olaby RR Cocquerel L Zemla A et al.

Source: PloS one [PLoS One] 2014 Oct 30; Vol. 9 (10), pp. e111333. Date of Electronic Publication: 2014 Oct 30 (Print Publication: 2014).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Virtual screening with AutoDock Vina and the common pharmacophore engine of a low diversity library of fragments and hits against the three allosteric sites of HIV integrase: participation in the SAMPL4 protein-ligand binding challenge.

Authors: Perryman AL Santiago DN Forli S et al.

Source: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2014 Apr; Vol. 28 (4), pp. 429-441. Date of Electronic Publication: 2014 Feb 04.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 8710425 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4951 (Electronic) Linking ISSN: 0920654X NLM ISO Abbreviation: J Comput Aided Mol Des Subsets: MEDLINE

Blind prediction of HIV integrase binding from the SAMPL4 challenge.

Authors: Mobley DL Liu S Lim NM et al.

Source: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2014 Apr; Vol. 28 (4), pp. 327-45. Date of Electronic Publication: 2014 Mar 05.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Review

Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 8710425 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4951 (Electronic) Linking ISSN: 0920654X NLM ISO Abbreviation: J Comput Aided Mol Des Subsets: MEDLINE

Virtual screening of integrase inhibitors by large scale binding free energy calculations: the SAMPL4 challenge.

Authors: Gallicchio E Deng N He P et al.

Source: Journal of computer-aided molecular design [J Comput Aided Mol Des] 2014 Apr; Vol. 28 (4), pp. 475-90. Date of Electronic Publication: 2014 Feb 07.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Springer Country of Publication: Netherlands NLM ID: 8710425 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-4951 (Electronic) Linking ISSN: 0920654X NLM ISO Abbreviation: J Comput Aided Mol Des Subsets: MEDLINE

Pruned Machine Learning Models to Predict Aqueous Solubility.

Authors: Perryman AL Inoyama D Patel JS et al.

Source: ACS omega [ACS Omega] 2020 Jul 01; Vol. 5 (27), pp. 16562-16567. Date of Electronic Publication: 2020 Jul 01 (Print Publication: 2020).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE