Search Results - "Petrassi HM"

Pharmacological Inhibition of SLC33A1 Promotes Endoplasmic Reticulum Hyperoxidation and Induces Adaptive IRE1/XBP1s Signaling.

Authors: Kutseikin S Rafiq M Bora P et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Feb 18. Date of Electronic Publication: 2026 Feb 18.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

SuFEx-based antitubercular compound irreversibly inhibits Pks13.

Authors: Krieger IV Sukheja P Yang B et al.

Source: Nature [Nature] 2025 Sep; Vol. 645 (8081), pp. 755-763. Date of Electronic Publication: 2025 Jul 30.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Discovery of Potent and Selective Pyridone-Based Small Molecule Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains.

Authors: Lederberg OL Yan NL Sanchez J et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Dec 12; Vol. 67 (23), pp. 21070-21105. Date of Electronic Publication: 2024 Dec 03.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Pharmacological and genetic activation of cAMP synthesis disrupts cholesterol utilization in Mycobacterium tuberculosis.

Authors: Wilburn KM Montague CR Qin B et al.

Source: PLoS pathogens [PLoS Pathog] 2022 Feb 08; Vol. 18 (2), pp. e1009862. Date of Electronic Publication: 2022 Feb 08 (Print Publication: 2022).

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic.

Authors: Chin EN Yu C Vartabedian VF et al.

Source: Science (New York, N.Y.) [Science] 2020 Aug 21; Vol. 369 (6506), pp. 993-999.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Synthesis and structure-activity relationships of aryl fluorosulfate-based inhibitors as novel antitubercular agents.

Authors: Yang B Sukheja P Qin B et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2024 Jan 15; Vol. 98, pp. 129596. Date of Electronic Publication: 2023 Dec 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis.

Authors: Yan NL Morgan GJ Petrassi HM et al.

Source: Current opinion in chemical biology [Curr Opin Chem Biol] 2023 Aug; Vol. 75, pp. 102319. Date of Electronic Publication: 2023 Jun 06.

Publication Type: Journal Article; Review; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Country of Publication: England NLM ID: 9811312 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0402 (Electronic) Linking ISSN: 13675931 NLM ISO Abbreviation: Curr Opin Chem Biol Subsets: MEDLINE

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.

Authors: Bakowski MA Shiroodi RK Liu R et al.

Source: Science translational medicine [Sci Transl Med] 2019 May 08; Vol. 11 (491).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

The Deconstructed Granuloma: A Complex High-Throughput Drug Screening Platform for the Discovery of Host-Directed Therapeutics Against Tuberculosis.

Authors: Huang L Kushner NL Theriault ME et al.

Source: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2018 Aug 14; Vol. 8, pp. 275. Date of Electronic Publication: 2018 Aug 14 (Print Publication: 2018).

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Frontiers Media SA Country of Publication: Switzerland NLM ID: 101585359 Publication Model: eCollection Cited Medium: Internet ISSN: 2235-2988 (Electronic) Linking ISSN: 22352988 NLM ISO Abbreviation: Front Cell Infect Microbiol

Cellular Target Deconvolution of Small Molecules Using a Selection-Based Genetic Screening Platform.

Authors: Zhao J Tang Z Selvaraju M et al.

Source: ACS central science [ACS Cent Sci] 2022 Oct 26; Vol. 8 (10), pp. 1424-1434. Date of Electronic Publication: 2022 Sep 22.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101660035 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2374-7943 (Print) Linking ISSN: 23747943 NLM ISO Abbreviation: ACS Cent Sci Subsets: PubMed not MEDLINE

The Tuberculosis Drug Accelerator at year 10: what have we learned?

Authors: Aldridge BB Barros-Aguirre D Barry CE 3rd et al.

Source: Nature medicine [Nat Med] 2021 Aug; Vol. 27 (8), pp. 1333-1337.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Company Country of Publication: United States NLM ID: 9502015 Publication Model: Print Cited Medium: Internet ISSN: 1546-170X (Electronic) Linking ISSN: 10788956 NLM ISO Abbreviation: Nat Med Subsets: MEDLINE

Suppressors of superoxide production from mitochondrial complex III.

Authors: Orr AL Vargas L Turk CN et al.

Source: Nature chemical biology [Nat Chem Biol] 2015 Nov; Vol. 11 (11), pp. 834-6. Date of Electronic Publication: 2015 Sep 14.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.

Authors: Yan NL Santos-Martins D Nair R et al.

Source: Journal of medicinal chemistry [J Med Chem] 2021 May 13; Vol. 64 (9), pp. 6273-6299. Date of Electronic Publication: 2021 May 03.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models.

Authors: Hübner MP Gunderson E Vogel I et al.

Source: International journal for parasitology. Drugs and drug resistance [Int J Parasitol Drugs Drug Resist] 2020 Apr; Vol. 12, pp. 18-27. Date of Electronic Publication: 2019 Dec 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101576715 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-3207 (Electronic) Linking ISSN: 22113207 NLM ISO Abbreviation: Int J Parasitol Drugs Drug Resist Subsets: MEDLINE

Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.

Authors: Liu YA Jin Q Zou Y et al.

Source: Journal of medicinal chemistry [J Med Chem] 2020 Mar 26; Vol. 63 (6), pp. 2958-2973. Date of Electronic Publication: 2020 Feb 20.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Rational design of potent human transthyretin amyloid disease inhibitors.

Authors: Klabunde T Petrassi HM Oza VB et al.

Source: Nature structural biology [Nat Struct Biol] 2000 Apr; Vol. 7 (4), pp. 312-21.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9421566 Publication Model: Print Cited Medium: Print ISSN: 1072-8368 (Print) Linking ISSN: 10728368 NLM ISO Abbreviation: Nat Struct Biol Subsets: MEDLINE

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.

Authors: Janes J Young ME Chen E et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 Oct 16; Vol. 115 (42), pp. 10750-10755. Date of Electronic Publication: 2018 Oct 03.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Small Molecules Targeting Mycobacterium tuberculosis Type II NADH Dehydrogenase Exhibit Antimycobacterial Activity.

Authors: Harbut MB Yang B Liu R et al.

Source: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2018 Mar 19; Vol. 57 (13), pp. 3478-3482. Date of Electronic Publication: 2018 Feb 22.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 0370543 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-3773 (Electronic) Linking ISSN: 14337851 NLM ISO Abbreviation: Angew Chem Int Ed Engl Subsets: MEDLINE

Targeted Disruption of Myc-Max Oncoprotein Complex by a Small Molecule.

Authors: Choi SH Mahankali M Lee SJ et al.

Source: ACS chemical biology [ACS Chem Biol] 2017 Nov 17; Vol. 12 (11), pp. 2715-2719. Date of Electronic Publication: 2017 Oct 11.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Suppressors of Superoxide-H2O2 Production at Site IQ of Mitochondrial Complex I Protect against Stem Cell Hyperplasia and Ischemia-Reperfusion Injury.

Authors: Brand MD Goncalves RL Orr AL et al.

Source: Cell metabolism [Cell Metab] 2016 Oct 11; Vol. 24 (4), pp. 582-592. Date of Electronic Publication: 2016 Sep 22.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101233170 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1932-7420 (Electronic) Linking ISSN: 15504131 NLM ISO Abbreviation: Cell Metab Subsets: MEDLINE