Search Results - "Premkumar DR"

MYCN drives pediatric glioma transformation from neural progenitors and creates distinct therapeutic vulnerabilities.

Authors: Gatesman TA Varadharajan S Johnson BJ et al.

Source: Cell reports [Cell Rep] 2026 Jun 23; Vol. 45 (6), pp. 117522. Date of Electronic Publication: 2026 Jun 12.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

Targeting mitochondrial energetics reverses panobinostat- and marizomib-induced resistance in pediatric and adult high-grade gliomas.

Authors: Jane EP Reslink MC Gatesman TA et al.

Source: Molecular oncology [Mol Oncol] 2023 Sep; Vol. 17 (9), pp. 1821-1843. Date of Electronic Publication: 2023 May 12.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101308230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0261 (Electronic) Linking ISSN: 15747891 NLM ISO Abbreviation: Mol Oncol Subsets: MEDLINE

Reversing tozasertib resistance in glioma through inhibition of pyruvate dehydrogenase kinases.

Authors: Jane EP Premkumar DR Rajasundaram D et al.

Source: Molecular oncology [Mol Oncol] 2022 Jan; Vol. 16 (1), pp. 219-249. Date of Electronic Publication: 2021 Jun 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: John Wiley & Sons, Inc Country of Publication: United States NLM ID: 101308230 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-0261 (Electronic) Linking ISSN: 15747891 NLM ISO Abbreviation: Mol Oncol Subsets: MEDLINE

An ERK5-PFKFB3 axis regulates glycolysis and represents a therapeutic vulnerability in pediatric diffuse midline glioma.

Authors: Casillo SM Gatesman TA Chilukuri A et al.

Source: Cell reports [Cell Rep] 2024 Jan 23; Vol. 43 (1), pp. 113557. Date of Electronic Publication: 2023 Dec 18.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101573691 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2211-1247 (Electronic) NLM ISO Abbreviation: Cell Rep Subsets: MEDLINE

Mitochondrial dysfunction RAD51, and Ku80 proteolysis promote apoptotic effects of Dinaciclib in Bcl-xL silenced cells.

Authors: Premkumar DR Jane EP Thambireddy S et al.

Source: Molecular carcinogenesis [Mol Carcinog] 2018 Apr; Vol. 57 (4), pp. 469-482. Date of Electronic Publication: 2017 Dec 30.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8811105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2744 (Electronic) Linking ISSN: 08991987 NLM ISO Abbreviation: Mol Carcinog Subsets: MEDLINE

Survivin inhibitor YM155 induces mitochondrial dysfunction, autophagy, DNA damage and apoptosis in Bcl-xL silenced glioma cell lines.

Authors: Jane EP Premkumar DR Sutera PA et al.

Source: Molecular carcinogenesis [Mol Carcinog] 2017 Apr; Vol. 56 (4), pp. 1251-1265. Date of Electronic Publication: 2016 Nov 22.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8811105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2744 (Electronic) Linking ISSN: 08991987 NLM ISO Abbreviation: Mol Carcinog Subsets: MEDLINE

The Quality of Online Resources Available to Patients Regarding Cannabidiol for Symptomatic Relief of Hip or Knee Arthritis is Poor.

Authors: Premkumar A Almeida BA Lopez J et al.

Source: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews [J Am Acad Orthop Surg Glob Res Rev] 2021 Jan 22; Vol. 5 (1), pp. 1-7. Date of Electronic Publication: 2021 Jan 22.

Publication Type: Journal Article

Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101724868 Publication Model: Electronic Cited Medium: Internet ISSN: 2474-7661 (Electronic) Linking ISSN: 24747661 NLM ISO Abbreviation: J Am Acad Orthop Surg Glob Res Rev Subsets: MEDLINE

Altmetrics Attention Scores for Randomized Controlled Trials in Total Joint Arthroplasty Are Reflective of High Scientific Quality: An Altmetrics-Based Methodological Quality and Bias Analysis.

Authors: Kunze KN Richardson M Bernstein DN et al.

Source: Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews [J Am Acad Orthop Surg Glob Res Rev] 2020 Dec; Vol. 4 (12), pp. e20.00187.

Publication Type: Journal Article

Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 101724868 Publication Model: Print Cited Medium: Internet ISSN: 2474-7661 (Electronic) Linking ISSN: 24747661 NLM ISO Abbreviation: J Am Acad Orthop Surg Glob Res Rev Subsets: MEDLINE

NVP-BKM120 potentiates apoptosis in tumor necrosis factor-related apoptosis-inducing ligand-resistant glioma cell lines via upregulation of Noxa and death receptor 5.

Authors: Foster KA Jane EP Premkumar DR et al.

Source: International journal of oncology [Int J Oncol] 2015 Aug; Vol. 47 (2), pp. 506-16. Date of Electronic Publication: 2015 Jun 05.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: D.A. Spandidos Country of Publication: Greece NLM ID: 9306042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1791-2423 (Electronic) Linking ISSN: 10196439 NLM ISO Abbreviation: Int J Oncol Subsets: MEDLINE

Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells.

Authors: Premkumar DR Jane EP Pollack IF

Source: Cancer biology & therapy [Cancer Biol Ther] 2015; Vol. 16 (2), pp. 233-43.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 101137842 Publication Model: Print Cited Medium: Internet ISSN: 1555-8576 (Electronic) Linking ISSN: 15384047 NLM ISO Abbreviation: Cancer Biol Ther Subsets: MEDLINE

Co-administration of ABT-737 and SAHA induces apoptosis, mediated by Noxa upregulation, Bax activation and mitochondrial dysfunction in PTEN-intact malignant human glioma cell lines.

Authors: Foster KA Jane EP Premkumar DR et al.

Source: Journal of neuro-oncology [J Neurooncol] 2014 Dec; Vol. 120 (3), pp. 459-72. Date of Electronic Publication: 2014 Aug 20.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309335 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7373 (Electronic) Linking ISSN: 0167594X NLM ISO Abbreviation: J Neurooncol Subsets: MEDLINE

Bortezomib-induced sensitization of malignant human glioma cells to vorinostat-induced apoptosis depends on reactive oxygen species production, mitochondrial dysfunction, Noxa upregulation, Mcl-1 cleavage, and DNA damage.

Authors: Premkumar DR Jane EP Agostino NR et al.

Source: Molecular carcinogenesis [Mol Carcinog] 2013 Feb; Vol. 52 (2), pp. 118-33. Date of Electronic Publication: 2011 Nov 15.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 8811105 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-2744 (Electronic) Linking ISSN: 08991987 NLM ISO Abbreviation: Mol Carcinog Subsets: MEDLINE

Targeting NAD⁺ Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance.

Authors: Jane EP Premkumar DR Thambireddy S et al.

Source: Molecular cancer research : MCR [Mol Cancer Res] 2020 Jul; Vol. 18 (7), pp. 1004-1017. Date of Electronic Publication: 2020 Apr 01.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 101150042 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3125 (Electronic) Linking ISSN: 15417786 NLM ISO Abbreviation: Mol Cancer Res Subsets: MEDLINE

L-type Ca(2+) channel activation regulates induction of c-fos transcription by hypoxia.

Authors: Premkumar DR Mishra RR Overholt JL et al.

Source: Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2000 May; Vol. 88 (5), pp. 1898-906.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 8502536 Publication Model: Print Cited Medium: Print ISSN: 8750-7587 (Print) Linking ISSN: 01617567 NLM ISO Abbreviation: J Appl Physiol (1985) Subsets: MEDLINE

Blunted respiratory responses to hypoxia in mutant mice deficient in nitric oxide synthase-3.

Authors: Kline DD Yang T Premkumar DR et al.

Source: Journal of applied physiology (Bethesda, Md. : 1985) [J Appl Physiol (1985)] 2000 Apr; Vol. 88 (4), pp. 1496-508.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 8502536 Publication Model: Print Cited Medium: Print ISSN: 8750-7587 (Print) Linking ISSN: 01617567 NLM ISO Abbreviation: J Appl Physiol (1985) Subsets: MEDLINE

Dinaciclib, a Cyclin-Dependent Kinase Inhibitor Promotes Proteasomal Degradation of Mcl-1 and Enhances ABT-737-Mediated Cell Death in Malignant Human Glioma Cell Lines.

Authors: Jane EP Premkumar DR Cavaleri JM et al.

Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2016 Feb; Vol. 356 (2), pp. 354-65. Date of Electronic Publication: 2015 Nov 19.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

Inhibition of phosphatidylinositol 3-kinase/AKT signaling by NVP-BKM120 promotes ABT-737-induced toxicity in a caspase-dependent manner through mitochondrial dysfunction and DNA damage response in established and primary cultured glioblastoma cells.

Authors: Jane EP Premkumar DR Morales A et al.

Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2014 Jul; Vol. 350 (1), pp. 22-35. Date of Electronic Publication: 2014 Apr 16.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

Survivin inhibitor YM-155 sensitizes tumor necrosis factor- related apoptosis-inducing ligand-resistant glioma cells to apoptosis through Mcl-1 downregulation and by engaging the mitochondrial death pathway.

Authors: Premkumar DR Jane EP Foster KA et al.

Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2013 Aug; Vol. 346 (2), pp. 201-10. Date of Electronic Publication: 2013 Jun 05.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

YM-155 potentiates the effect of ABT-737 in malignant human glioma cells via survivin and Mcl-1 downregulation in an EGFR-dependent context.

Authors: Jane EP Premkumar DR DiDomenico JD et al.

Source: Molecular cancer therapeutics [Mol Cancer Ther] 2013 Mar; Vol. 12 (3), pp. 326-38. Date of Electronic Publication: 2013 Jan 16.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

ABT-737 synergizes with bortezomib to induce apoptosis, mediated by Bid cleavage, Bax activation, and mitochondrial dysfunction in an Akt-dependent context in malignant human glioma cell lines.

Authors: Premkumar DR Jane EP DiDomenico JD et al.

Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 2012 Jun; Vol. 341 (3), pp. 859-72. Date of Electronic Publication: 2012 Mar 05.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0103 (Electronic) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE