Search Results - "Pyruvate dehydrogenase complex"

Decreased Glucose Metabolism and Declined Chaperones Are Unique Features Required for the Survival of Senescent Fibroblasts and Pyruvate Dehydrogenase Is a Potent Senolytic Target.

Authors: Zhang M Hu Z Piao S et al.

Source: Aging cell [Aging Cell] 2026 Mar; Vol. 25 (3), pp. e70434.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101130839 Publication Model: Print Cited Medium: Internet ISSN: 1474-9726 (Electronic) Linking ISSN: 14749718 NLM ISO Abbreviation: Aging Cell Subsets: MEDLINE

Understanding the role of pyruvate dehydrogenase in Listeria monocytogenes virulence.

Authors: Freeman MJ Eral NJ Debrine AM et al.

Source: Infection and immunity [Infect Immun] 2026 Jul 14; Vol. 94 (7), pp. e0050525. Date of Electronic Publication: 2026 May 29.

Publication Type: Journal Article

Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0246127 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5522 (Electronic) Linking ISSN: 00199567 NLM ISO Abbreviation: Infect Immun Subsets: MEDLINE

Serial Prenatal Imaging of Ganglionic Eminence Evolution: A PDHA1-Variant Case Demonstrating Metabolic Brain Injury Dynamics.

Authors: Tian T Chen H Luo H et al.

Source: Journal of clinical ultrasound : JCU [J Clin Ultrasound] 2026 Jul-Aug; Vol. 54 (6), pp. 1514-1516. Date of Electronic Publication: 2026 Feb 27.

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Wiley Subscription Services, Inc Country of Publication: United States NLM ID: 0401663 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0096 (Electronic) Linking ISSN: 00912751 NLM ISO Abbreviation: J Clin Ultrasound Subsets: MEDLINE

Sex-Specific Relationships between Cerebral Cortex Metabolism, Behavior, and ECG Parameters in Rats under Physiological Conditions and after Pyruvate Dehydrogenase Inhibition.

Authors: Graf AV Kazantsev AV Bunik VI

Source: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2026 Jun; Vol. 91 (6), pp. 1006-1022.

Publication Type: Journal Article

Journal Info: Publisher: MAIK Nauka/Interperiodica Country of Publication: United States NLM ID: 0376536 Publication Model: Print Cited Medium: Internet ISSN: 1608-3040 (Electronic) Linking ISSN: 00062979 NLM ISO Abbreviation: Biochemistry (Mosc) Subsets: MEDLINE

The pyruvate dehydrogenase complex at the crossroads of cancer metabolism and cell death.

Authors: Cai X Chen F Liang R et al.

Source: Cell chemical biology [Cell Chem Biol] 2026 Jul 16; Vol. 33 (7), pp. 966-981.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

The genotypic and phenotypic landscape of PDHA1-related pyruvate dehydrogenase complex deficiency.

Authors: Merkevicius K Smirnov D Schlieben LD et al.

Source: Brain : a journal of neurology [Brain] 2026 Jul 07; Vol. 149 (7), pp. 2344-2362.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0372537 Publication Model: Print Cited Medium: Internet ISSN: 1460-2156 (Electronic) Linking ISSN: 00068950 NLM ISO Abbreviation: Brain Subsets: MEDLINE

The immunometabolic role of pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis in cardiovascular disease and beyond.

Authors: Grentzmann A Ketelhuth DFJ

Source: Cardiovascular research [Cardiovasc Res] 2026 Jun 26; Vol. 122 (9), pp. 1133-1142.

Publication Type: Journal Article; Review

Journal Info: Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE

Depression, anxiety, and stress impair sperm quality via dysregulation of the mitochondrial PDK-PDC axis.

Authors: Wang W Qikai W Zilin W et al.

Source: Reproductive biology and endocrinology : RB&E [Reprod Biol Endocrinol] 2025 Sep 30; Vol. 23 (1), pp. 127. Date of Electronic Publication: 2025 Sep 30.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101153627 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-7827 (Electronic) Linking ISSN: 14777827 NLM ISO Abbreviation: Reprod Biol Endocrinol Subsets: MEDLINE

Ketogenic diet therapy in pyruvate dehydrogenase deficiency: Global clinical practice from literature and survey data.

Authors: Madsen S Allender B Blackford R et al.

Corporate Authors: Madsen S Allender B Blackford R et al.

Source: Molecular genetics and metabolism [Mol Genet Metab] 2026 Aug; Vol. 148 (4), pp. 110190. Date of Electronic Publication: 2026 Jun 18.

Publication Type: Journal Article; Review

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9805456 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-7206 (Electronic) Linking ISSN: 10967192 NLM ISO Abbreviation: Mol Genet Metab Subsets: MEDLINE

Metabolic modulation of pyruvate dehydrogenase and glucose oxidation in diabetic cardiomyopathy: pathways, perspectives, and potentials.

Authors: Chan JSF Dong L Ussher JR

Source: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2025 Nov 01; Vol. 329 (5), pp. H1142-H1153. Date of Electronic Publication: 2025 Sep 15.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901228 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1539 (Electronic) Linking ISSN: 03636135 NLM ISO Abbreviation: Am J Physiol Heart Circ Physiol Subsets: MEDLINE

Solvent accessibility of E1α and E1β residues with known missense mutations causing pyruvate dehydrogenase complex (PDC) deficiency: Impact on PDC-E1 structure and function.

Authors: Ducich NH Mears JA Bedoyan JK

Source: Journal of inherited metabolic disease [J Inherit Metab Dis] 2022 May; Vol. 45 (3), pp. 557-570. Date of Electronic Publication: 2022 Feb 01.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 7910918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2665 (Electronic) Linking ISSN: 01418955 NLM ISO Abbreviation: J Inherit Metab Dis Subsets: MEDLINE

Novel imaging findings in pyruvate dehydrogenase complex (PDHc) deficiency-Results from a nationwide population-based study.

Authors: Savvidou A Ivarsson L Naess K et al.

Source: Journal of inherited metabolic disease [J Inherit Metab Dis] 2022 Mar; Vol. 45 (2), pp. 248-263. Date of Electronic Publication: 2021 Dec 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 7910918 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2665 (Electronic) Linking ISSN: 01418955 NLM ISO Abbreviation: J Inherit Metab Dis Subsets: MEDLINE

Structural diversity of pyruvate dehydrogenase complexes.

Authors: Bothe SN Zdanowicz R

Source: FEBS letters [FEBS Lett] 2026 May; Vol. 600 (10), pp. 1475-1490. Date of Electronic Publication: 2025 Aug 13.

Publication Type: Journal Article; Review

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

Mycobacterium tuberculosis assembles a unique hexameric E2p core of the pyruvate dehydrogenase complex.

Authors: Hsu HC Bonnet I Bryk R et al.

Source: The Journal of biological chemistry [J Biol Chem] 2026 Apr; Vol. 302 (4), pp. 111284. Date of Electronic Publication: 2026 Feb 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Pyruvate Dehydrogenase Complex Deficiency: A Review of Treatments and Case Series.

Authors: Betesh-Abay B Shany E Staretz-Chacham O et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2026 Mar 17; Vol. 27 (6). Date of Electronic Publication: 2026 Mar 17.

Publication Type: Journal Article; Review; Case Reports

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer.

Authors: Patel MS Rideout TC

Source: International journal of cancer [Int J Cancer] 2026 Mar 15; Vol. 158 (6), pp. 1464-1480. Date of Electronic Publication: 2025 Oct 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-0215 (Electronic) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE

The pyruvate dehydrogenase complex as a cytoadhesin in Mycoplasma bovis that binds host extracellular matrix components.

Authors: Cui W Lan S Li Z et al.

Source: International journal of biological macromolecules [Int J Biol Macromol] 2026 Mar; Vol. 351, pp. 151125. Date of Electronic Publication: 2026 Feb 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 7909578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0003 (Electronic) Linking ISSN: 01418130 NLM ISO Abbreviation: Int J Biol Macromol Subsets: MEDLINE

Targeting the pyruvate dehydrogenase kinase/pyruvate dehydrogenase axis modulates neutrophil and smooth muscle cell pathological responses and prevents abdominal aortic aneurysm formation.

Authors: Griepke S Grentzmann A Tripodi GL et al.

Source: Cardiovascular research [Cardiovasc Res] 2025 Jul 31; Vol. 121 (8), pp. 1269-1281.

Publication Type: Journal Article

Journal Info: Publisher: Oxford Journals Country of Publication: England NLM ID: 0077427 Publication Model: Print Cited Medium: Internet ISSN: 1755-3245 (Electronic) Linking ISSN: 00086363 NLM ISO Abbreviation: Cardiovasc Res Subsets: MEDLINE

Improvement of lactic acidosis in pyruvate dehydrogenase complex deficiency using custom-made amino acid-based dialysate for peritoneal dialysis.

Authors: Kuok MCI Chow CKJ Chan NM et al.

Source: Pediatric nephrology (Berlin, Germany) [Pediatr Nephrol] 2025 Jul; Vol. 40 (7), pp. 2201-2203. Date of Electronic Publication: 2025 Jan 29.

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: Springer International Country of Publication: Germany NLM ID: 8708728 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-198X (Electronic) Linking ISSN: 0931041X NLM ISO Abbreviation: Pediatr Nephrol Subsets: MEDLINE

A Nationwide Study of Pyruvate Dehydrogenase Complex Deficiency in Sweden: Epidemiology, Genotype-Phenotype Correlations, and Survival.

Authors: Savvidou A Sofou K Thunström S et al.

Source: Neurology [Neurology] 2026 May 12; Vol. 106 (9), pp. e214924. Date of Electronic Publication: 2026 Apr 14.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0401060 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-632X (Electronic) Linking ISSN: 00283878 NLM ISO Abbreviation: Neurology Subsets: MEDLINE