Search Results - "Rayner SL"

TDP-43 is coming to the cottage: A new tool to study neurodegenerative diseases.

Authors: Rayner SL Gitler AD

Source: PLoS biology [PLoS Biol] 2026 Mar 25; Vol. 24 (3), pp. e3003697. Date of Electronic Publication: 2026 Mar 25 (Print Publication: 2026).

Publication Type: Journal Article; Comment

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

Proteomics Analysis of the TDP-43 Interactome in Cellular Models of ALS Pathogenesis.

Authors: Cheng F Chapman T Venturato J et al.

Source: Journal of neurochemistry [J Neurochem] 2025 May; Vol. 169 (5), pp. e70079.

Publication Type: Journal Article

Journal Info: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE

TDP-43 nuclear loss in FTD/ALS causes widespread alternative polyadenylation changes.

Authors: Zeng Y Lovchykova A Akiyama T et al.

Source: Nature neuroscience [Nat Neurosci] 2025 Nov; Vol. 28 (11), pp. 2180-2189. Date of Electronic Publication: 2025 Oct 21.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: United States NLM ID: 9809671 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1726 (Electronic) Linking ISSN: 10976256 NLM ISO Abbreviation: Nat Neurosci Subsets: MEDLINE

Cyclin F, Neurodegeneration, and the Pathogenesis of ALS/FTD.

Authors: Rayner SL Hogan A Davidson JM et al.

Source: The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [Neuroscientist] 2024 Apr; Vol. 30 (2), pp. 214-228. Date of Electronic Publication: 2022 Sep 05.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Sage Publications Country of Publication: United States NLM ID: 9504819 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-4098 (Electronic) Linking ISSN: 10738584 NLM ISO Abbreviation: Neuroscientist Subsets: MEDLINE

The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis.

Authors: Davidson JM Wu SSL Rayner SL et al.

Source: Molecular neurobiology [Mol Neurobiol] 2023 Sep; Vol. 60 (9), pp. 5034-5054. Date of Electronic Publication: 2023 May 27.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 8900963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-1182 (Electronic) Linking ISSN: 08937648 NLM ISO Abbreviation: Mol Neurobiol Subsets: MEDLINE

ALS-linked CCNF variant disrupts motor neuron ubiquitin homeostasis.

Authors: Farrawell NE Bax M McAlary L et al.

Source: Human molecular genetics [Hum Mol Genet] 2023 Jul 04; Vol. 32 (14), pp. 2386-2398.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

Identification of phosphorylated tau protein interactors in progressive supranuclear palsy (PSP) reveals networks involved in protein degradation, stress response, cytoskeletal dynamics, metabolic processes, and neurotransmission.

Authors: Radford RAW Rayner SL Szwaja P et al.

Source: Journal of neurochemistry [J Neurochem] 2023 May; Vol. 165 (4), pp. 563-586. Date of Electronic Publication: 2023 Mar 21.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley on behalf of the International Society for Neurochemistry Country of Publication: England NLM ID: 2985190R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-4159 (Electronic) Linking ISSN: 00223042 NLM ISO Abbreviation: J Neurochem Subsets: MEDLINE

Understanding age-related pathologic changes in TDP-43 functions and the consequence on RNA splicing and signalling in health and disease.

Authors: Cheng F Chapman T Zhang S et al.

Source: Ageing research reviews [Ageing Res Rev] 2024 Apr; Vol. 96, pp. 102246. Date of Electronic Publication: 2024 Feb 23.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE

Cyclin F can alter the turnover of TDP-43.

Authors: Rayner SL Hogan A Davidson JM et al.

Source: Neurobiology of disease [Neurobiol Dis] 2024 Mar; Vol. 192, pp. 106421. Date of Electronic Publication: 2024 Jan 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

ALS/FTD-causing mutation in cyclin F causes the dysregulation of SFPQ.

Authors: Rayner SL Cheng F Hogan AL et al.

Source: Human molecular genetics [Hum Mol Genet] 2021 May 31; Vol. 30 (11), pp. 971-984.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE

Unbiased Label-Free Quantitative Proteomics of Cells Expressing Amyotrophic Lateral Sclerosis (ALS) Mutations in CCNF Reveals Activation of the Apoptosis Pathway: A Workflow to Screen Pathogenic Gene Mutations.

Authors: Cheng F De Luca A Hogan AL et al.

Source: Frontiers in molecular neuroscience [Front Mol Neurosci] 2021 Apr 27; Vol. 14, pp. 627740. Date of Electronic Publication: 2021 Apr 27 (Print Publication: 2021).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477914 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5099 (Print) Linking ISSN: 16625099 NLM ISO Abbreviation: Front Mol Neurosci Subsets: PubMed not MEDLINE

TDP-43 as a therapeutic target in neurodegenerative diseases: Focusing on motor neuron disease and frontotemporal dementia.

Authors: Babazadeh A Rayner SL Lee A et al.

Source: Ageing research reviews [Ageing Res Rev] 2023 Dec; Vol. 92, pp. 102085. Date of Electronic Publication: 2023 Oct 08.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 101128963 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9649 (Electronic) Linking ISSN: 15681637 NLM ISO Abbreviation: Ageing Res Rev Subsets: MEDLINE

ALS/FTD-associated mutation in cyclin F inhibits ER-Golgi trafficking, inducing ER stress, ERAD and Golgi fragmentation.

Authors: Ragagnin AMG Sundaramoorthy V Farzana F et al.

Source: Scientific reports [Sci Rep] 2023 Nov 22; Vol. 13 (1), pp. 20467. Date of Electronic Publication: 2023 Nov 22.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

Inter-Regional Proteomic Profiling of the Human Brain Using an Optimized Protein Extraction Method from Formalin-Fixed Tissue to Identify Signaling Pathways.

Authors: Davidson JM Rayner SL Liu S et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2023 Feb 21; Vol. 24 (5). Date of Electronic Publication: 2023 Feb 21.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Using proteomics to identify ubiquitin ligase-substrate pairs: how novel methods may unveil therapeutic targets for neurodegenerative diseases.

Authors: Rayner SL Morsch M Molloy MP et al.

Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2019 Jul; Vol. 76 (13), pp. 2499-2510. Date of Electronic Publication: 2019 Mar 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

Proteomics Approaches for Biomarker and Drug Target Discovery in ALS and FTD.

Authors: Hedl TJ San Gil R Cheng F et al.

Source: Frontiers in neuroscience [Front Neurosci] 2019 Jun 11; Vol. 13, pp. 548. Date of Electronic Publication: 2019 Jun 11 (Print Publication: 2019).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101478481 Publication Model: eCollection Cited Medium: Print ISSN: 1662-4548 (Print) Linking ISSN: 1662453X NLM ISO Abbreviation: Front Neurosci Subsets: PubMed not MEDLINE

Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype.

Authors: Hogan AL Don EK Rayner SL et al.

Source: Human molecular genetics [Hum Mol Genet] 2019 Feb 15; Vol. 28 (4), pp. 698.

Publication Type: Journal Article; Published Erratum

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: PubMed not MEDLINE

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy.

Authors: Lee A Rayner SL Gwee SSL et al.

Source: Cellular and molecular life sciences : CMLS [Cell Mol Life Sci] 2018 Jan; Vol. 75 (2), pp. 335-354. Date of Electronic Publication: 2017 Aug 29.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer Country of Publication: Switzerland NLM ID: 9705402 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1420-9071 (Electronic) Linking ISSN: 1420682X NLM ISO Abbreviation: Cell Mol Life Sci Subsets: MEDLINE

TDP-43 is a ubiquitylation substrate of the SCF^{cyclin F} complex.

Authors: Rayner SL Yang S Farrawell NE et al.

Source: Neurobiology of disease [Neurobiol Dis] 2022 Jun 01; Vol. 167, pp. 105673. Date of Electronic Publication: 2022 Feb 26.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9500169 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-953X (Electronic) Linking ISSN: 09699961 NLM ISO Abbreviation: Neurobiol Dis Subsets: MEDLINE

Expression of ALS/FTD-linked mutant CCNF in zebrafish leads to increased cell death in the spinal cord and an aberrant motor phenotype.

Authors: Hogan AL Don EK Rayner SL et al.

Source: Human molecular genetics [Hum Mol Genet] 2017 Jul 15; Vol. 26 (14), pp. 2616-2626.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: IRL Press at Oxford University Press Country of Publication: England NLM ID: 9208958 Publication Model: Print Cited Medium: Internet ISSN: 1460-2083 (Electronic) Linking ISSN: 09646906 NLM ISO Abbreviation: Hum Mol Genet Subsets: MEDLINE