Search Results - "Read KD"

Untargeted metabolomics for triaging of cytochrome b inhibitors during Chagas' disease drug discovery.

Authors: MacLeod AK Tulloch LB Tinti M et al.

Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2026 Jan 20; Vol. 20 (1), pp. e0013917. Date of Electronic Publication: 2026 Jan 20 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE

Identification and Evaluation of Dibasic Piperidines as Cell Wall Inhibitors against Mycobacterium tuberculosis.

Authors: Naylor C Prosser G Bayliss T et al.

Source: ACS infectious diseases [ACS Infect Dis] 2026 Jun 12; Vol. 12 (6), pp. 2004-2014. Date of Electronic Publication: 2026 May 14.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Structure-Guided Optimization of Novel Inhibitors of Plasmodium Lysyl-tRNA Synthetase with Multistage Activity against Malaria Parasites.

Authors: Forte B Bellany F Campbell PS et al.

Source: Journal of medicinal chemistry [J Med Chem] 2026 Jun 11; Vol. 69 (11), pp. 13820-13855. Date of Electronic Publication: 2026 Jun 02.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

5‑Nitrofuran-Semicarbazone Hybrids as Antitrypanosomal Agents: Structure-Activity Relationship and Nitroreductase Activation.

Authors: Alegbejo Price TO Silva DG Vaidergorn MM et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 May 26; Vol. 17 (6), pp. 1398-1406. Date of Electronic Publication: 2026 May 26 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Discovery of a CNS active GSK3 degrader using orthogonally reactive linker screening.

Authors: Holmqvist A Kocaturk NM Duncan C et al.

Source: Nature communications [Nat Commun] 2025 Oct 06; Vol. 16 (1), pp. 8857. Date of Electronic Publication: 2025 Oct 06.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Use of a cytochrome P450 humanized mouse model to refine schistosomiasis drug discovery.

Authors: Davey SD Forde-Thomas JE Hulme BJ et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2026 Apr 14; Vol. 123 (15), pp. e2600197123. Date of Electronic Publication: 2026 Apr 10.

Publication Type: Journal Article

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis.

Authors: Naylor C Prosser GA Bayliss T et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 30. Date of Electronic Publication: 2026 Jan 30.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Humanization of Drug Metabolism in the Plasmodium berghei Mouse Model for Antimalarial Drug Discovery.

Authors: MacLeod AK Merino C Viera-Morilla S et al.

Source: ACS infectious diseases [ACS Infect Dis] 2025 Dec 12; Vol. 11 (12), pp. 3529-3541. Date of Electronic Publication: 2025 Nov 30.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Compounds Reducing Human Sperm Motility as Potential Nonhormonal Contraceptives Identified Using a High-Throughput Phenotypic Screening Platform.

Authors: Richardson A Gruber FS Day DP et al.

Source: ACS omega [ACS Omega] 2025 Nov 27; Vol. 10 (48), pp. 59121-59134. Date of Electronic Publication: 2025 Nov 27 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE

Targeting dihydroorotate dehydrogenase (DHODH) for host-directed therapy: Discovery of a novel alkyne-based scaffold inhibitor effective against SARS-CoV-2.

Authors: Vaidergorn MM Purificação AD Leite PIP et al.

Source: European journal of medicinal chemistry [Eur J Med Chem] 2025 Nov 05; Vol. 297, pp. 117876. Date of Electronic Publication: 2025 Jun 21.

Publication Type: Journal Article

Journal Info: Publisher: Editions Scientifiques Elsevier Country of Publication: France NLM ID: 0420510 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1768-3254 (Electronic) Linking ISSN: 02235234 NLM ISO Abbreviation: Eur J Med Chem Subsets: MEDLINE

Cryptosporidium lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy.

Authors: Caldwell N Peet C Miller P et al.

Source: Science translational medicine [Sci Transl Med] 2024 Oct 23; Vol. 16 (770), pp. eadm8631. Date of Electronic Publication: 2024 Oct 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

Log D7.4 and plasma protein binding of synthetic cannabinoid receptor agonists and a comparison of experimental and predicted lipophilicity.

Authors: Brandon AM Baginski SR Peet C et al.

Source: Drug testing and analysis [Drug Test Anal] 2024 Sep; Vol. 16 (9), pp. 1012-1025. Date of Electronic Publication: 2023 Dec 08.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: John Wiley & Sons Country of Publication: England NLM ID: 101483449 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1942-7611 (Electronic) Linking ISSN: 19427603 NLM ISO Abbreviation: Drug Test Anal Subsets: MEDLINE

Application of a mouse model humanized for cytochrome P450-mediated drug metabolism to predict drug-drug interactions between a peptide and small molecule drugs.

Authors: Kapelyukh Y Gabel-Jensen C MacLeod AK et al.

Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2025 Oct; Vol. 53 (10), pp. 100153. Date of Electronic Publication: 2025 Aug 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

Small molecule inhibitors of the NorA multidrug efflux pump potentiate antibiotic activity by binding the outward-open conformation.

Authors: Gray JL Ledger EVK Suwatthee T et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Aug 22. Date of Electronic Publication: 2025 Aug 22.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Computationally guided optimization of the antimalarial activity and physicochemical properties of 2,4-diaminopyrimidines.

Authors: Guntur G Gleeson D Anderson M et al.

Source: RSC medicinal chemistry [RSC Med Chem] 2025 Aug 20. Date of Electronic Publication: 2025 Aug 20.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem

Design and Development of Lysyl tRNA Synthetase Inhibitors, for the Treatment of Tuberculosis.

Authors: Davis SH Mathieson M Buchanan KI et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Aug 14; Vol. 68 (15), pp. 16459-16482. Date of Electronic Publication: 2025 Aug 01.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Sperm Toolbox-A selection of small molecules to study human spermatozoa.

Authors: Gruber FS Richardson A Johnston ZC et al.

Source: PloS one [PLoS One] 2024 Feb 20; Vol. 19 (2), pp. e0297666. Date of Electronic Publication: 2024 Feb 20 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Short-course combination treatment for experimental chronic Chagas disease.

Authors: González S Wall RJ Thomas J et al.

Source: Science translational medicine [Sci Transl Med] 2023 Dec 13; Vol. 15 (726), pp. eadg8105. Date of Electronic Publication: 2023 Dec 13.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

High-Throughput Screening of Potent Drug-like Molecules Targeting 17β-HSD10 for the Treatment of Alzheimer's Disease and Cancer.

Authors: Aitken L Baillie G Pannifer A et al.

Source: ACS chemical biology [ACS Chem Biol] 2025 Jul 18; Vol. 20 (7), pp. 1544-1559. Date of Electronic Publication: 2025 Jun 18.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Open-science discovery of DNDI-6510, a compound that addresses genotoxic and metabolic liabilities of the COVID Moonshot SARS-CoV-2 Mpro lead inhibitor.

Authors: Griffen EJ Fearon D McGovern BL et al.

Corporate Authors: Griffen EJ Fearon D McGovern BL et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Jun 17. Date of Electronic Publication: 2025 Jun 17.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE