Search Results - "Rotella DP"

Correction to "Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties".

Authors: Mahmood SU Boddu RK Eberhard J et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Mar 26; Vol. 17 (4), pp. 952. Date of Electronic Publication: 2026 Mar 26 (Print Publication: 2026).

Publication Type: Published Erratum

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Potent, Selective Pyrrolopyrimidine PDE11A4 Inhibitors with Improved Pharmaceutical Properties.

Authors: Mahmood SU Boddu RK Eberhard J et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Jan 30; Vol. 17 (2), pp. 547-553. Date of Electronic Publication: 2026 Jan 30 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Versatile Imidazole Scaffold with Potent Activity against Multiple Apicomplexan Parasites.

Authors: Khim M Montgomery J Laureano De Souza M et al.

Source: ACS infectious diseases [ACS Infect Dis] 2025 Jun 13; Vol. 11 (6), pp. 1497-1507. Date of Electronic Publication: 2025 May 08.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Molecular mechanisms regulating PDE11A4 age-related liquid-liquid phase separation (LLPS) and its reversal by selective, potent and orally-available PDE11A4 small molecule inhibitors both in vitro and in vivo.

Authors: Amurrio E Patel J Danaher M et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 21. Date of Electronic Publication: 2025 May 21.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Characterization of Competitive Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.

Authors: Eck T Laureano de Souza M Delvillar M et al.

Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2022 Apr 05; Vol. 23 (7), pp. e202100704. Date of Electronic Publication: 2022 Feb 23.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

First Demonstration of In Vivo PDE11A4 Target Engagement for Potential Treatment of Age-Related Memory Disorders.

Authors: Mahmood SU Eberhard J Hoffman CS et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Oct 10; Vol. 67 (19), pp. 17774-17784. Date of Electronic Publication: 2024 Sep 25.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Correction to "Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials".

Authors: Gilleran JA Ashraf K Delvillar M et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Jul 25; Vol. 67 (14), pp. 12459. Date of Electronic Publication: 2024 Jul 10.

Publication Type: Published Erratum

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE; PubMed not MEDLINE

Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.

Authors: Gilleran JA Ashraf K Delvillar M et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Mar 14; Vol. 67 (5), pp. 3467-3503. Date of Electronic Publication: 2024 Feb 19.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

First Optimization of Novel, Potent, Selective PDE11A4 Inhibitors for Age-Related Cognitive Decline.

Authors: Mahmood SU Lozano Gonzalez M Tummalapalli S et al.

Source: Journal of medicinal chemistry [J Med Chem] 2023 Nov 09; Vol. 66 (21), pp. 14597-14608. Date of Electronic Publication: 2023 Oct 20.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Patrick M. Woster Memorial Commentary.

Authors: Rotella DP Georg G

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Oct 03; Vol. 14 (10), pp. 1305-1309. Date of Electronic Publication: 2023 Oct 03 (Print Publication: 2023).

Publication Type: Editorial

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Patrick M. Woster Memorial Commentary.

Authors: Rotella DP Georg G

Source: Journal of medicinal chemistry [J Med Chem] 2023 Sep 28; Vol. 66 (18), pp. 12645-12649. Date of Electronic Publication: 2023 Sep 08.

Publication Type: Editorial

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE; PubMed not MEDLINE

Successes in antiviral drug discovery: a tribute to Nick Meanwell.

Authors: Rotella DP; Department of Chemistry and Biochemistry, Sokol Institute of Pharmaceutical Life Sciences, Montclair State University, Montclair, NJ 07043 USA.

Source: Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents [Med Chem Res] 2023 Jun 08, pp. 1-10. Date of Electronic Publication: 2023 Jun 08.

Publication Type: Journal Article; Review

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 9211347 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1054-2523 (Print) Linking ISSN: 10542523 NLM ISO Abbreviation: Med Chem Res

Expression, purification, and inhibition profile of dihydrofolate reductase from the filarial nematode Wuchereria bancrofti.

Authors: Tobias AM Toska D Lange K et al.

Source: PloS one [PLoS One] 2018 May 22; Vol. 13 (5), pp. e0197173. Date of Electronic Publication: 2018 May 22 (Print Publication: 2018).

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Discovery of Imidazole-Based Inhibitors of Plasmodium falciparum cGMP-Dependent Protein Kinase.

Authors: Bheemanaboina RRY de Souza ML Gonzalez ML et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Nov 15; Vol. 12 (12), pp. 1962-1967. Date of Electronic Publication: 2021 Nov 15 (Print Publication: 2021).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

The spectral properties of (-)-epigallocatechin 3-O-gallate (EGCG) fluorescence in different solvents: dependence on solvent polarity.

Authors: Snitsarev V Young MN Miller RM et al.

Source: PloS one [PLoS One] 2013 Nov 22; Vol. 8 (11), pp. e79834. Date of Electronic Publication: 2013 Nov 22 (Print Publication: 2013).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Discovery of isoxazolyl-based inhibitors of Plasmodium falciparum cGMP-dependent protein kinase.

Authors: Mahmood SU Cheng H Tummalapalli SR et al.

Source: RSC medicinal chemistry [RSC Med Chem] 2019 Dec 16; Vol. 11 (1), pp. 98-101. Date of Electronic Publication: 2019 Dec 16 (Print Publication: 2020).

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem Subsets: PubMed not MEDLINE

Phosphodiesterase 5 inhibitors: current status and potential applications.

Authors: Rotella DP; Hopewell Discovery Chemistry, Bristol-Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, USA. david.rotella@bms.com

Source: Nature reviews. Drug discovery [Nat Rev Drug Discov] 2002 Sep; Vol. 1 (9), pp. 674-82.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124171 Publication Model: Print Cited Medium: Print ISSN: 1474-1776 (Print) Linking ISSN: 14741776 NLM ISO Abbreviation: Nat Rev Drug Discov Subsets: MEDLINE

Discovery of a Stress-Activated Protein Kinase Inhibitor for Lymphatic Filariasis.

Authors: Tummalapalli SR Bhat R Chojnowski A et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Feb 09; Vol. 9 (3), pp. 210-214. Date of Electronic Publication: 2018 Feb 09 (Print Publication: 2018).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Mechanism of inhibition of botulinum neurotoxin type A light chain by two quinolinol compounds.

Authors: Minnow YV Goldberg R Tummalapalli SR et al.

Source: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2017 Mar 15; Vol. 618, pp. 15-22. Date of Electronic Publication: 2017 Jan 28.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0384 (Electronic) Linking ISSN: 00039861 NLM ISO Abbreviation: Arch Biochem Biophys Subsets: MEDLINE

The Critical Role of Organic Chemistry in Drug Discovery.

Authors: Rotella DP; Sokol Professor of Chemistry and Biochemistry Sokol Institute of Pharmaceutical Life Sciences Department of Chemistry and Biochemistry, Montclair State University , Montclair, New Jersey 07043, United States.

Source: ACS chemical neuroscience [ACS Chem Neurosci] 2016 Oct 19; Vol. 7 (10), pp. 1315-1316. Date of Electronic Publication: 2016 Sep 13.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE