Search Results - "Ruston, Linette"

Lanthanide tweezer complexes for luminescence detection of aromatic pollutants in water.

Authors: Glover, Peter B. Senkiw-Smith, Lauren Ruston, Linette L. et al.

Source: Chemical Communications. 5/26/2026, Vol. 62 Issue 40, p10189-10192. 4p.

Discovery of AZD3147: A Potent, Selective Dual Inhibitor of mTORC1 and mTORC2.

Authors: Pike, Kurt G. Morris, Jeff Ruston, Linette et al.

Source: Journal of Medicinal Chemistry. Mar2015, Vol. 58 Issue 5, p2326-2349. 24p.

IMI – Oral biopharmaceutics tools project – Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies.

Authors: Ahmad, Amais Pepin, Xavier Aarons, Leon et al.

Source: European Journal of Pharmaceutics & Biopharmaceutics. Nov2020, Vol. 156, p50-63. 14p.

Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors.

Authors: Barlaam, Bernard Cosulich, Sabina Fitzek, Martina et al.

Source: Bioorganic & Medicinal Chemistry Letters. Jul2017, Vol. 27 Issue 13, p3030-3035. 6p.

Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.

Authors: Barlaam, Bernard Cosulich, Sabina Fitzek, Martina et al.

Source: Bioorganic & Medicinal Chemistry Letters. Jul2015, Vol. 25 Issue 13, p2679-2685. 7p.

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Authors: Pike, Kurt G. Malagu, Karine Hummersone, Marc G. et al.

Source: Bioorganic & Medicinal Chemistry Letters. Mar2013, Vol. 23 Issue 5, p1212-1216. 5p.

Determining bioequivalence possibilities of long acting injectables through population PK modelling.

Authors: Gajjar, Parmesh Dickinson, Jake Dickinson, Harri et al.

Source: European Journal of Pharmaceutical Sciences. Dec2022, Vol. 179, pN.PAG-N.PAG. 1p.

A Phase 1 Randomized, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Enteric-Coated Stabilized Sulforaphane (SFX-01) in Male Participants.

Authors: Clack G Moore C Ruston L et al.

Source: Advances in therapy [Adv Ther] 2025 Jan; Vol. 42 (1), pp. 216-232. Date of Electronic Publication: 2024 Nov 09.

Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Health Communications Inc Country of Publication: United States NLM ID: 8611864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-8652 (Electronic) Linking ISSN: 0741238X NLM ISO Abbreviation: Adv Ther Subsets: MEDLINE

Discovery and Preclinical Evaluation of a Novel Inhibitor of FABP5, ART26.12, Effective in Oxaliplatin-Induced Peripheral Neuropathy.

Authors: Warren G Osborn M Tsantoulas C et al.

Source: The journal of pain [J Pain] 2024 Jul; Vol. 25 (7), pp. 104470. Date of Electronic Publication: 2024 Jan 15.

Publication Type: Journal Article

Journal Info: Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 100898657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-8447 (Electronic) Linking ISSN: 15265900 NLM ISO Abbreviation: J Pain Subsets: MEDLINE

Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.

Authors: Su Q Banks E Bebernitz G et al.

Source: Journal of medicinal chemistry [J Med Chem] 2020 May 14; Vol. 63 (9), pp. 4517-4527. Date of Electronic Publication: 2020 Apr 28.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.

Authors: Grimster NP Anderson E Alimzhanov M et al.

Source: Journal of medicinal chemistry [J Med Chem] 2018 Jun 28; Vol. 61 (12), pp. 5235-5244. Date of Electronic Publication: 2018 Jun 13.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers.

Authors: Barlaam B Cosulich S Delouvrié B et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Nov 15; Vol. 25 (22), pp. 5155-62. Date of Electronic Publication: 2015 Oct 09.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.

Authors: Addie M Ballard P Buttar D et al.

Source: Journal of medicinal chemistry [J Med Chem] 2013 Mar 14; Vol. 56 (5), pp. 2059-73. Date of Electronic Publication: 2013 Feb 26.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Luminescence screening assays for the identification of sensitizers for lanthanides based on the controlled formation of ternary lanthanide complexes with DTPA-bisamide ligands.

Authors: Ruston LL Robertson GM Pikramenou Z

Source: Chemistry, an Asian journal [Chem Asian J] 2010 Mar 01; Vol. 5 (3), pp. 571-80.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101294643 Publication Model: Print Cited Medium: Internet ISSN: 1861-471X (Electronic) Linking ISSN: 1861471X NLM ISO Abbreviation: Chem Asian J Subsets: MEDLINE

Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.

Authors: Leach AG Jones HD Cosgrove DA et al.

Source: Journal of medicinal chemistry [J Med Chem] 2006 Nov 16; Vol. 49 (23), pp. 6672-82.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE