Search Results - "Ruston L"

1000TiP Novel next generation PARP1-selective and CNS penetrant inhibitor DSB2455: A phase Ia/Ib open label, multi-centre dose escalation study with expansion cohorts to assess the safety, tolerability, and activity as monotherapy in participants with advanced malignancies

Authors: Yarza, R. Garralda, E. Sánchez Perez, V. et al.

Source: Annals of Oncology. 2025 Supplement 2, Vol. 36, pS653-S653. 1p.

The Touring Machine System.

Authors: Arango, M. Bahler, L. Bates, P. et al.

Source: Communications of the ACM. Jan1993, Vol. 36 Issue 1, p68-77. 10p.

Subjects: Multimedia systems, Computer software, Telecommunication, Computer networks, Access control, Application software, Computer architecture

A Phase 1 Randomized, Placebo-Controlled Study Evaluating the Safety, Tolerability, and Pharmacokinetics of Enteric-Coated Stabilized Sulforaphane (SFX-01) in Male Participants.

Authors: Clack G Moore C Ruston L et al.

Source: Advances in therapy [Adv Ther] 2025 Jan; Vol. 42 (1), pp. 216-232. Date of Electronic Publication: 2024 Nov 09.

Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase I; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Health Communications Inc Country of Publication: United States NLM ID: 8611864 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1865-8652 (Electronic) Linking ISSN: 0741238X NLM ISO Abbreviation: Adv Ther Subsets: MEDLINE

Response to Letter to the Editor: Fixed High Energy Versus Standard Titrated Energy Settings for Selective Laser Trabeculoplasty.

Authors: Purt B Danielson DT Jin SJ et al.

Source: Journal of glaucoma [J Glaucoma] 2025 Jan 01; Vol. 34 (1), pp. e2-e3. Date of Electronic Publication: 2024 Oct 11.

Publication Type: Journal Article

Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9300903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-481X (Electronic) Linking ISSN: 10570829 NLM ISO Abbreviation: J Glaucoma Subsets: MEDLINE; In Process

Discovery and Preclinical Evaluation of a Novel Inhibitor of FABP5, ART26.12, Effective in Oxaliplatin-Induced Peripheral Neuropathy.

Authors: Warren G Osborn M Tsantoulas C et al.

Source: The journal of pain [J Pain] 2024 Jul; Vol. 25 (7), pp. 104470. Date of Electronic Publication: 2024 Jan 15.

Publication Type: Journal Article

Journal Info: Publisher: Churchill Livingstone Country of Publication: United States NLM ID: 100898657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1528-8447 (Electronic) Linking ISSN: 15265900 NLM ISO Abbreviation: J Pain Subsets: MEDLINE

Fixed High Energy Versus Standard Titrated Energy Settings for Selective Laser Trabeculoplasty.

Authors: Danielson DT Purt B Jin SJ et al.

Source: Journal of glaucoma [J Glaucoma] 2023 Aug 01; Vol. 32 (8), pp. 673-680. Date of Electronic Publication: 2023 May 25.

Publication Type: Journal Article

Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 9300903 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1536-481X (Electronic) Linking ISSN: 10570829 NLM ISO Abbreviation: J Glaucoma Subsets: MEDLINE

Determining bioequivalence possibilities of long acting injectables through population PK modelling.

Authors: Gajjar P Dickinson J Dickinson H et al.

Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2022 Dec 01; Vol. 179, pp. 106296. Date of Electronic Publication: 2022 Sep 20.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

IMI - Oral biopharmaceutics tools project - Evaluation of bottom-up PBPK prediction success part 4: Prediction accuracy and software comparisons with improved data and modelling strategies.

Authors: Ahmad A Pepin X Aarons L et al.

Source: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2020 Nov; Vol. 156, pp. 50-63. Date of Electronic Publication: 2020 Aug 14.

Publication Type: Comparative Study; Evaluation Study; Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9109778 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3441 (Electronic) Linking ISSN: 09396411 NLM ISO Abbreviation: Eur J Pharm Biopharm Subsets: MEDLINE

Discovery of (2R)-N-[3-[2-[(3-Methoxy-1-methyl-pyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propenamide (AZD4205) as a Potent and Selective Janus Kinase 1 Inhibitor.

Authors: Su Q Banks E Bebernitz G et al.

Source: Journal of medicinal chemistry [J Med Chem] 2020 May 14; Vol. 63 (9), pp. 4517-4527. Date of Electronic Publication: 2020 Apr 28.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery and Optimization of a Novel Series of Highly Selective JAK1 Kinase Inhibitors.

Authors: Grimster NP Anderson E Alimzhanov M et al.

Source: Journal of medicinal chemistry [J Med Chem] 2018 Jun 28; Vol. 61 (12), pp. 5235-5244. Date of Electronic Publication: 2018 Jun 13.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors.

Authors: Barlaam B Cosulich S Fitzek M et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2017 Jul 01; Vol. 27 (13), pp. 3030-3035. Date of Electronic Publication: 2017 May 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers.

Authors: Barlaam B Cosulich S Delouvrié B et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Nov 15; Vol. 25 (22), pp. 5155-62. Date of Electronic Publication: 2015 Oct 09.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.

Authors: Barlaam B Cosulich S Fitzek M et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Jul 01; Vol. 25 (13), pp. 2679-85. Date of Electronic Publication: 2015 Apr 29.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Discovery of AZD3147: a potent, selective dual inhibitor of mTORC1 and mTORC2.

Authors: Pike KG Morris J Ruston L et al.

Source: Journal of medicinal chemistry [J Med Chem] 2015 Mar 12; Vol. 58 (5), pp. 2326-49. Date of Electronic Publication: 2015 Feb 18.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Roth spots in native valve endocarditis.

Authors: Hess RL; OD, MC (FS), USN, 400 Stillwater Landing Way, Apt 198, Sneads Ferry, NC 28460-6925. hesseyecare@aol.com.

Source: The Journal of the American Osteopathic Association [J Am Osteopath Assoc] 2013 Nov; Vol. 113 (11), pp. 863.

Publication Type: Case Reports; Journal Article

Journal Info: Publisher: American Osteopathic Association Country of Publication: United States NLM ID: 7503065 Publication Model: Print Cited Medium: Internet ISSN: 1945-1997 (Electronic) Linking ISSN: 00986151 NLM ISO Abbreviation: J Am Osteopath Assoc Subsets: MEDLINE

Discovery of 4-amino-N-[(1S)-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an orally bioavailable, potent inhibitor of Akt kinases.

Authors: Addie M Ballard P Buttar D et al.

Source: Journal of medicinal chemistry [J Med Chem] 2013 Mar 14; Vol. 56 (5), pp. 2059-73. Date of Electronic Publication: 2013 Feb 26.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: the discovery of AZD8055 and AZD2014.

Authors: Pike KG Malagu K Hummersone MG et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Mar 01; Vol. 23 (5), pp. 1212-6. Date of Electronic Publication: 2013 Jan 18.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure.

Authors: Leach AG Jones HD Cosgrove DA et al.

Source: Journal of medicinal chemistry [J Med Chem] 2006 Nov 16; Vol. 49 (23), pp. 6672-82.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Influenza outbreak in a long-term-care facility: considerations for pharmacy.

Authors: Bowles SK Kennie N Ruston L et al.

Source: American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists [Am J Health Syst Pharm] 1999 Nov 15; Vol. 56 (22), pp. 2303-7.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 9503023 Publication Model: Print Cited Medium: Print ISSN: 1079-2082 (Print) Linking ISSN: 10792082 NLM ISO Abbreviation: Am J Health Syst Pharm Subsets: MEDLINE