Search Results - "Schimpl M"

Accuracy of the actibelt((R)) accelerometer for measuring walking speed in a controlled environment among persons with multiple sclerosis.

Authors: Motl RW Weikert M Suh Y et al.

Source: Gait & Posture. Feb2012, Vol. 35 Issue 2, p192-196.

Ecological Validity of Walking Capacity Tests in Multiple Sclerosis.

Authors: Stellmann, J. P. Neuhaus, A. Götze, N. et al.

Source: PLoS ONE. Apr2015, Vol. 10 Issue 4, p1-11. 11p.

Generative AI-Assisted Discovery of HPK1 Inhibitors.

Authors: Giblin KA Song K Chen H et al.

Source: Journal of medicinal chemistry [J Med Chem] 2026 Aug 13; Vol. 69 (15), pp. 18723-18738.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Genetic evidence for PARP1 trapping as a driver of PARP inhibitor efficacy in BRCA mutant cancer cells.

Authors: Ribeiro J Hansen K van Beek L et al.

Source: Nucleic acids research [Nucleic Acids Res] 2025 Nov 26; Vol. 53 (22).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Development of D-box peptides to inhibit the anaphase-promoting complex/cyclosome.

Authors: Eapen R Okoye C Stubbs C et al.

Source: ELife [Elife] 2025 Sep 01; Vol. 14. Date of Electronic Publication: 2025 Sep 01.

Publication Type: Journal Article

Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

Synthetic chemistry enabling the discovery and development of a series of pyrazoles as HPK1 inhibitors.

Authors: Metrano AJ Morrill LA Bommakanti G et al.

Source: RSC medicinal chemistry [RSC Med Chem] 2025 May 27; Vol. 16 (8), pp. 3522-3529. Date of Electronic Publication: 2025 May 27 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem Subsets: PubMed not MEDLINE

Discovery of Pyrimidoindolones as Novel Family VIII Bromodomain Binders.

Authors: Boerth JA Schimpl M Lucas SCC et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2025 May 08; Vol. 16 (6), pp. 1073-1079. Date of Electronic Publication: 2025 May 08 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor.

Authors: Shields JD Baker D Balazs AYS et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Feb 27; Vol. 68 (4), pp. 4582-4595. Date of Electronic Publication: 2025 Feb 10.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.

Authors: Johannes JW Balazs AYS Barratt D et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Dec 26; Vol. 67 (24), pp. 21717-21728. Date of Electronic Publication: 2024 Dec 10.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Accelerated Discovery of Carbamate Cbl-b Inhibitors Using Generative AI Models and Structure-Based Drug Design.

Authors: Quinn TR Giblin KA Thomson C et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Aug 22; Vol. 67 (16), pp. 14210-14233. Date of Electronic Publication: 2024 Aug 12.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Development of a Series of Pyrrolopyridone MAT2A Inhibitors.

Authors: Atkinson SJ Bagal SK Argyrou A et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Mar 28; Vol. 67 (6), pp. 4541-4559. Date of Electronic Publication: 2024 Mar 11.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.

Authors: Ogden TEH Yang JC Schimpl M et al.

Source: Nucleic acids research [Nucleic Acids Res] 2021 Feb 26; Vol. 49 (4), pp. 2266-2288.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

A-loop interactions in Mer tyrosine kinase give rise to inhibitors with two-step mechanism and long residence time of binding.

Authors: Pflug A Schimpl M Nissink JWM et al.

Source: The Biochemical journal [Biochem J] 2020 Nov 27; Vol. 477 (22), pp. 4443-4452.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Published by Portland Press on behalf of the Biochemical Society Country of Publication: England NLM ID: 2984726R Publication Model: Print Cited Medium: Internet ISSN: 1470-8728 (Electronic) Linking ISSN: 02646021 NLM ISO Abbreviation: Biochem J Subsets: MEDLINE

Discovery, Optimization, and Biological Evaluation of Arylpyridones as Cbl-b Inhibitors.

Authors: Mfuh AM Boerth JA Bommakanti G et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Jan 25; Vol. 67 (2), pp. 1500-1512. Date of Electronic Publication: 2024 Jan 16.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of a Novel Benzodiazepine Series of Cbl-b Inhibitors for the Enhancement of Antitumor Immunity.

Authors: Boerth JA Chinn AJ Schimpl M et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Nov 17; Vol. 14 (12), pp. 1848-1856. Date of Electronic Publication: 2023 Nov 17 (Print Publication: 2023).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Combining structural and coevolution information to unveil allosteric sites.

Authors: La Sala G Pfleger C Käck H et al.

Source: Chemical science [Chem Sci] 2023 Jun 08; Vol. 14 (25), pp. 7057-7067. Date of Electronic Publication: 2023 Jun 08 (Print Publication: 2023).

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

Author Correction: The active site of O-GlcNAc transferase imposes constraints on substrate sequence.

Authors: Pathak S Alonso J Schimpl M et al.

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2023 Apr; Vol. 30 (4), pp. 564.

Publication Type: Published Erratum

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE; PubMed not MEDLINE

Optimization of hERG and Pharmacokinetic Properties for Basic Dihydro-8H-purin-8-one Inhibitors of DNA-PK.

Authors: Goldberg FW Ting AKT Beattie D et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Jul 07; Vol. 13 (8), pp. 1295-1301. Date of Electronic Publication: 2022 Jul 07 (Print Publication: 2022).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models.

Authors: Winter-Holt JJ Bardelle C Chiarparin E et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Feb 24; Vol. 65 (4), pp. 3306-3331. Date of Electronic Publication: 2022 Feb 08.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}-N-methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.

Authors: Johannes JW Balazs A Barratt D et al.

Source: Journal of medicinal chemistry [J Med Chem] 2021 Oct 14; Vol. 64 (19), pp. 14498-14512. Date of Electronic Publication: 2021 Sep 27.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE