Search Results - "Sharp PP"

N‑Alkyl and N‑Aryl Aminopyrazole Spirocarbamates: A Two-Pronged Lead Optimization Strategy to Identify Orally Bioavailable Plasma Kallikrein Inhibitors.

Authors: Merchant RR Chernyak N Lopez JA et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2026 Feb 24; Vol. 17 (3), pp. 744-749. Date of Electronic Publication: 2026 Feb 24 (Print Publication: 2026).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Inhibition of the Sec61 translocon overcomes cytokine-induced glucocorticoid resistance in T-cell acute lymphoblastic leukaemia.

Authors: Meyer LK Delgado-Martin C Sharp PP et al.

Source: British journal of haematology [Br J Haematol] 2022 Jul; Vol. 198 (1), pp. 137-141. Date of Electronic Publication: 2022 Apr 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 0372544 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2141 (Electronic) Linking ISSN: 00071048 NLM ISO Abbreviation: Br J Haematol Subsets: MEDLINE

Author Correction: CIS is a potent checkpoint in NK cell-mediated tumor immunity.

Authors: Delconte RB Kolesnik TB Dagley LF et al.

Source: Nature immunology [Nat Immunol] 2024 Feb; Vol. 25 (2), pp. 371-372.

Publication Type: Published Erratum

Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE; PubMed not MEDLINE

Signal peptide mimicry primes Sec61 for client-selective inhibition.

Authors: Rehan S Tranter D Sharp PP et al.

Source: Nature chemical biology [Nat Chem Biol] 2023 Sep; Vol. 19 (9), pp. 1054-1062. Date of Electronic Publication: 2023 May 11.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

Inhibitors of Eukaryotic Translational Machinery as Therapeutic Agents.

Authors: Fan A Sharp PP

Source: Journal of medicinal chemistry [J Med Chem] 2021 Mar 11; Vol. 64 (5), pp. 2436-2465. Date of Electronic Publication: 2021 Feb 16.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

A RIPK2 inhibitor delays NOD signalling events yet prevents inflammatory cytokine production.

Authors: Nachbur U Stafford CA Bankovacki A et al.

Source: Nature communications [Nat Commun] 2015 Mar 17; Vol. 6, pp. 6442. Date of Electronic Publication: 2015 Mar 17.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Simplified silvestrol analogues with potent cytotoxic activity.

Authors: Hawkins BC Lindqvist LM Nhu D et al.

Source: ChemMedChem [ChemMedChem] 2014 Jul; Vol. 9 (7), pp. 1556-66. Date of Electronic Publication: 2014 Mar 27.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.

Authors: Gordon DE Jang GM Bouhaddou M et al.

Source: Nature [Nature] 2020 Jul; Vol. 583 (7816), pp. 459-468. Date of Electronic Publication: 2020 Apr 30.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.

Authors: Gordon DE Jang GM Bouhaddou M et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2020 Mar 27. Date of Electronic Publication: 2020 Mar 27.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Total Syntheses of the 3H-Pyrrolo[2,3-c]quinolone-Containing Alkaloids Marinoquinolines A-F, K, and Aplidiopsamine A Using a Palladium-Catalyzed Ullmann Cross-Coupling/Reductive Cyclization Pathway.

Authors: Bolte B Bryan CS Sharp PP et al.

Source: The Journal of organic chemistry [J Org Chem] 2020 Jan 17; Vol. 85 (2), pp. 650-663. Date of Electronic Publication: 2019 Dec 18.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE; PubMed not MEDLINE

A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis.

Authors: van Delft MF Chappaz S Khakham Y et al.

Source: Nature chemical biology [Nat Chem Biol] 2019 Nov; Vol. 15 (11), pp. 1057-1066. Date of Electronic Publication: 2019 Oct 07.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101231976 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1552-4469 (Electronic) Linking ISSN: 15524450 NLM ISO Abbreviation: Nat Chem Biol Subsets: MEDLINE

Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.

Authors: Shah PS Link N Jang GM et al.

Source: Cell [Cell] 2018 Dec 13; Vol. 175 (7), pp. 1931-1945.e18.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE

Mechanistic Studies on the Base-Promoted Conversion of Alkoxy-Substituted, Ring-Fused gem-Dihalocyclopropanes into Furans: Evidence for a Process Involving Electrocyclic Ring Closure of a Carbonyl Ylide Intermediate.

Authors: Sharp PP Mikusek J Ho J et al.

Source: The Journal of organic chemistry [J Org Chem] 2018 Nov 16; Vol. 83 (22), pp. 13678-13690. Date of Electronic Publication: 2018 Oct 26.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 2985193R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6904 (Electronic) Linking ISSN: 00223263 NLM ISO Abbreviation: J Org Chem Subsets: MEDLINE; PubMed not MEDLINE

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors.

Authors: Sharp PP Garnier JM Hatfaludi T et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2017 Nov 14; Vol. 8 (12), pp. 1298-1303. Date of Electronic Publication: 2017 Nov 14 (Print Publication: 2017).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Synthesis of a GlcNAcylated arginine building block for the solid phase synthesis of death domain glycopeptide fragments.

Authors: Wang S Corcilius L Sharp PP et al.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2017 Jun 01; Vol. 25 (11), pp. 2895-2900. Date of Electronic Publication: 2017 Mar 07.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Synthesis of rhamnosylated arginine glycopeptides and determination of the glycosidic linkage in bacterial elongation factor P.

Authors: Wang S Corcilius L Sharp PP et al.

Source: Chemical science [Chem Sci] 2017 Mar 01; Vol. 8 (3), pp. 2296-2302. Date of Electronic Publication: 2016 Dec 12.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

BET inhibition represses miR17-92 to drive BIM-initiated apoptosis of normal and transformed hematopoietic cells.

Authors: Xu Z Sharp PP Yao Y et al.

Source: Leukemia [Leukemia] 2016 Jul; Vol. 30 (7), pp. 1531-41. Date of Electronic Publication: 2016 Mar 08.

Publication Type: Historical Article; Journal Article

Journal Info: Publisher: Nature Publishing Group, Specialist Journals Country of Publication: England NLM ID: 8704895 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5551 (Electronic) Linking ISSN: 08876924 NLM ISO Abbreviation: Leukemia Subsets: MEDLINE

CIS is a potent checkpoint in NK cell-mediated tumor immunity.

Authors: Delconte RB Kolesnik TB Dagley LF et al.

Source: Nature immunology [Nat Immunol] 2016 Jul; Vol. 17 (7), pp. 816-24. Date of Electronic Publication: 2016 May 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells.

Authors: Baker EK Taylor S Gupte A et al.

Source: Scientific reports [Sci Rep] 2015 May 06; Vol. 5, pp. 10120. Date of Electronic Publication: 2015 May 06.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE

BET bromodomain inhibitors: a patent review.

Authors: Garnier JM Sharp PP Burns CJ

Source: Expert opinion on therapeutic patents [Expert Opin Ther Pat] 2014 Feb; Vol. 24 (2), pp. 185-99. Date of Electronic Publication: 2013 Nov 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Informa Healthcare Country of Publication: England NLM ID: 9516419 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-7674 (Electronic) Linking ISSN: 13543776 NLM ISO Abbreviation: Expert Opin Ther Pat Subsets: MEDLINE