Search Results - "Shepard RL"

Association of intestinal peptide transport with a protein related to the cadherin superfamily.

Authors: Dantzig AH Hoskins JA Tabas LB et al.

Source: Science (New York, N.Y.) [Science] 1994 Apr 15; Vol. 264 (5157), pp. 430-3.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Print ISSN: 0036-8075 (Print) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), an Enzyme Essential for NAD+ Biosynthesis, Leads to Altered Carbohydrate Metabolism in Cancer Cells.

Authors: Tan B Dong S Shepard RL et al.

Source: The Journal of biological chemistry [J Biol Chem] 2015 Jun 19; Vol. 290 (25), pp. 15812-15824. Date of Electronic Publication: 2015 May 05.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Efficacy of low-dose oral metronomic dosing of the prodrug of gemcitabine, LY2334737, in human tumor xenografts.

Authors: Pratt SE Durland-Busbice S Shepard RL et al.

Source: Molecular cancer therapeutics [Mol Cancer Ther] 2013 Apr; Vol. 12 (4), pp. 481-90. Date of Electronic Publication: 2013 Jan 31.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells.

Authors: Pratt SE Durland-Busbice S Shepard RL et al.

Source: Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2013 Mar 01; Vol. 19 (5), pp. 1159-68. Date of Electronic Publication: 2013 Jan 16.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 9502500 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3265 (Electronic) Linking ISSN: 10780432 NLM ISO Abbreviation: Clin Cancer Res Subsets: MEDLINE

Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: metabolic basis and potential clinical implications.

Authors: Tan B Young DA Lu ZH et al.

Source: The Journal of biological chemistry [J Biol Chem] 2013 Feb 01; Vol. 288 (5), pp. 3500-11. Date of Electronic Publication: 2012 Dec 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators.

Authors: Perry WL 3rd Shepard RL Sampath J et al.

Source: Cancer research [Cancer Res] 2005 Aug 01; Vol. 65 (15), pp. 6593-600.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print Cited Medium: Print ISSN: 0008-5472 (Print) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.

Authors: Pratt S Shepard RL Kandasamy RA et al.

Source: Molecular cancer therapeutics [Mol Cancer Ther] 2005 May; Vol. 4 (5), pp. 855-63.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print Cited Medium: Print ISSN: 1535-7163 (Print) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE

Evaluation of the binding of the tricyclic isoxazole photoaffinity label LY475776 to multidrug resistance associated protein 1 (MRP1) orthologs and several ATP- binding cassette (ABC) drug transporters.

Authors: Dantzig AH Shepard RL Pratt SE et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 2004 Mar 15; Vol. 67 (6), pp. 1111-21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Human SPF45, a splicing factor, has limited expression in normal tissues, is overexpressed in many tumors, and can confer a multidrug-resistant phenotype to cells.

Authors: Sampath J Long PR Shepard RL et al.

Source: The American journal of pathology [Am J Pathol] 2003 Nov; Vol. 163 (5), pp. 1781-90.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370502 Publication Model: Print Cited Medium: Print ISSN: 0002-9440 (Print) Linking ISSN: 00029440 NLM ISO Abbreviation: Am J Pathol Subsets: MEDLINE

Modulation of P-glycoprotein but not MRP1- or BCRP-mediated drug resistance by LY335979.

Authors: Shepard RL Cao J Starling JJ et al.

Source: International journal of cancer [Int J Cancer] 2003 Jan 01; Vol. 103 (1), pp. 121-5.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-Liss Country of Publication: United States NLM ID: 0042124 Publication Model: Print Cited Medium: Print ISSN: 0020-7136 (Print) Linking ISSN: 00207136 NLM ISO Abbreviation: Int J Cancer Subsets: MEDLINE

Photolabeling of human and murine multidrug resistance protein 1 with the high affinity inhibitor [125I]LY475776 and azidophenacyl-[35S]glutathione.

Authors: Qian YM Grant CE Westlake CJ et al.

Source: The Journal of biological chemistry [J Biol Chem] 2002 Sep 20; Vol. 277 (38), pp. 35225-31. Date of Electronic Publication: 2002 Jul 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

GSH-dependent photolabeling of multidrug resistance protein MRP1 (ABCC1) by [125I]LY475776. Evidence of a major binding site in the COOH-proximal membrane spanning domain.

Authors: Mao Q Qiu W Weigl KE et al.

Source: The Journal of biological chemistry [J Biol Chem] 2002 Aug 09; Vol. 277 (32), pp. 28690-9. Date of Electronic Publication: 2002 May 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.

Authors: Ekins S Kim RB Leake BF et al.

Source: Molecular pharmacology [Mol Pharmacol] 2002 May; Vol. 61 (5), pp. 964-73.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print Cited Medium: Print ISSN: 0026-895X (Print) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates.

Authors: Ekins S Kim RB Leake BF et al.

Source: Molecular pharmacology [Mol Pharmacol] 2002 May; Vol. 61 (5), pp. 974-81.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print Cited Medium: Print ISSN: 0026-895X (Print) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

Cytotoxic responses to aromatic ring and configurational variations in alpha-conidendrin, podophyllotoxin, and sikkimotoxin derivatives.

Authors: Dantzig A LaLonde RT Ramdayal F et al.

Source: Journal of medicinal chemistry [J Med Chem] 2001 Jan 18; Vol. 44 (2), pp. 180-5.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146.

Authors: Norman BH Dantzig AH Kroin JS et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 1999 Dec 06; Vol. 9 (23), pp. 3381-6.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Evaluation of an in vitro coculture model for the blood-brain barrier: comparison of human umbilical vein endothelial cells (ECV304) and rat glioma cells (C6) from two commercial sources.

Authors: Scism JL Laska DA Horn JW et al.

Source: In vitro cellular & developmental biology. Animal [In Vitro Cell Dev Biol Anim] 1999 Nov-Dec; Vol. 35 (10), pp. 580-92.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 9418515 Publication Model: Print Cited Medium: Print ISSN: 1071-2690 (Print) Linking ISSN: 10712690 NLM ISO Abbreviation: In Vitro Cell Dev Biol Anim Subsets: MEDLINE

Selectivity of the multidrug resistance modulator, LY335979, for P-glycoprotein and effect on cytochrome P-450 activities.

Authors: Dantzig AH Shepard RL Law KL et al.

Source: The Journal of pharmacology and experimental therapeutics [J Pharmacol Exp Ther] 1999 Aug; Vol. 290 (2), pp. 854-62.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0376362 Publication Model: Print Cited Medium: Print ISSN: 0022-3565 (Print) Linking ISSN: 00223565 NLM ISO Abbreviation: J Pharmacol Exp Ther Subsets: MEDLINE

Effect of modulators on the ATPase activity and vanadate nucleotide trapping of human P-glycoprotein.

Authors: Shepard RL Winter MA Hsaio SC et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 1998 Sep 15; Vol. 56 (6), pp. 719-27.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print Cited Medium: Print ISSN: 0006-2952 (Print) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Pharmacological characterization of LY335979: a potent cyclopropyldibenzosuberane modulator of P-glycoprotein.

Authors: Starling JJ Shepard RL Cao J et al.

Source: Advances in enzyme regulation [Adv Enzyme Regul] 1997; Vol. 37, pp. 335-47.

Publication Type: Journal Article

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0044263 Publication Model: Print Cited Medium: Print ISSN: 0065-2571 (Print) Linking ISSN: 00652571 NLM ISO Abbreviation: Adv Enzyme Regul Subsets: MEDLINE