Search Results - "Sheth PR"

Deep mutational scanning reveals pharmacologically relevant insights into TYK2 signaling and disease.

Authors: Howard CJ Abell NS Warneford-Thomson RR et al.

Source: ELife [Elife] 2026 Jun 10; Vol. 15. Date of Electronic Publication: 2026 Jun 10.

Publication Type: Journal Article

Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

LC-MS measurement of triglyceride hydrolysis: Application in studies of Patatin-like phospholipase domain-containing protein 3 activity.

Authors: Chen X Koglin M Gregory MC et al.

Source: Analytical biochemistry [Anal Biochem] 2026 Jul; Vol. 714, pp. 116111. Date of Electronic Publication: 2026 Mar 14.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0309 (Electronic) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

Isotope Fractionation during Gas Chromatography Can Enhance Mass Spectrometry-Based Measures of ²H-Labeling of Small Molecules.

Authors: Downes DP Kasumov T Daurio NA et al.

Source: Metabolites [Metabolites] 2020 Nov 20; Vol. 10 (11). Date of Electronic Publication: 2020 Nov 20.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE

Using measures of metabolic flux to align screening and clinical development: Avoiding pitfalls to enable translational studies.

Authors: Satapati S Downes DP Metzger D et al.

Source: SLAS discovery : advancing life sciences R & D [SLAS Discov] 2022 Jan; Vol. 27 (1), pp. 20-28. Date of Electronic Publication: 2021 Nov 02.

Publication Type: Journal Article

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 101697563 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2472-5560 (Electronic) Linking ISSN: 24725552 NLM ISO Abbreviation: SLAS Discov Subsets: MEDLINE

Chemical Genetic Analysis and Functional Characterization of Staphylococcal Wall Teichoic Acid 2-Epimerases Reveals Unconventional Antibiotic Drug Targets.

Authors: Mann PA Müller A Wolff KA et al.

Source: PLoS pathogens [PLoS Pathog] 2016 May 04; Vol. 12 (5), pp. e1005585. Date of Electronic Publication: 2016 May 04 (Print Publication: 2016).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.

Authors: Lee SH Wang H Labroli M et al.

Source: Science translational medicine [Sci Transl Med] 2016 Mar 09; Vol. 8 (329), pp. 329ra32.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

Selective small-molecule inhibition of an RNA structural element.

Authors: Howe JA Wang H Fischmann TO et al.

Source: Nature [Nature] 2015 Oct 29; Vol. 526 (7575), pp. 672-7. Date of Electronic Publication: 2015 Sep 30.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Direct Analysis from Phase-Separated Liquid Samples using ADE-OPI-MS: Applicability to High-Throughput Screening for Inhibitors of Diacylglycerol Acyltransferase 2.

Authors: Wen X Liu C Ghislain L et al.

Source: Analytical chemistry [Anal Chem] 2021 Apr 20; Vol. 93 (15), pp. 6071-6079. Date of Electronic Publication: 2021 Apr 05.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6882 (Electronic) Linking ISSN: 00032700 NLM ISO Abbreviation: Anal Chem Subsets: MEDLINE

Mapping Lipogenic Flux: A Gold LDI-MS Approach for Imaging Neutral Lipid Kinetics.

Authors: Downes DP Zhong W Zhang J et al.

Source: Journal of the American Society for Mass Spectrometry [J Am Soc Mass Spectrom] 2020 Dec 02; Vol. 31 (12), pp. 2421-2425. Date of Electronic Publication: 2020 Sep 01.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 9010412 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1123 (Electronic) Linking ISSN: 10440305 NLM ISO Abbreviation: J Am Soc Mass Spectrom Subsets: MEDLINE

Examining Targeted Protein Degradation from Physiological and Analytical Perspectives: Enabling Translation between Cells and Subjects.

Authors: Daurio NA Zhou H Chen Y et al.

Source: ACS chemical biology [ACS Chem Biol] 2020 Oct 16; Vol. 15 (10), pp. 2623-2635. Date of Electronic Publication: 2020 Sep 30.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Epitopes and Mechanism of Action of the Clostridium difficile Toxin A-Neutralizing Antibody Actoxumab.

Authors: Hernandez LD Kroh HK Hsieh E et al.

Source: Journal of molecular biology [J Mol Biol] 2017 Apr 07; Vol. 429 (7), pp. 1030-1044. Date of Electronic Publication: 2017 Feb 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 2985088R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1089-8638 (Electronic) Linking ISSN: 00222836 NLM ISO Abbreviation: J Mol Biol Subsets: MEDLINE

Quantitation of wall teichoic acid in Staphylococcus aureus by direct measurement of monomeric units using LC-MS/MS.

Authors: Berejnaia O Wang H Labroli M et al.

Source: Analytical biochemistry [Anal Biochem] 2017 Feb 01; Vol. 518, pp. 9-15. Date of Electronic Publication: 2016 Nov 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0309 (Electronic) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

Benzimidazole analogs as WTA biosynthesis inhibitors targeting methicillin resistant Staphylococcus aureus.

Authors: Yang SW Pan J Yang C et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2016 Oct 01; Vol. 26 (19), pp. 4743-4747. Date of Electronic Publication: 2016 Aug 16.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling.

Authors: Hernandez LD Racine F Xiao L et al.

Source: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Feb; Vol. 59 (2), pp. 1052-60. Date of Electronic Publication: 2014 Dec 01.

Publication Type: Clinical Trial, Phase II; Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 0315061 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-6596 (Electronic) Linking ISSN: 00664804 NLM ISO Abbreviation: Antimicrob Agents Chemother Subsets: MEDLINE

Mechanism of action and epitopes of Clostridium difficile toxin B-neutralizing antibody bezlotoxumab revealed by X-ray crystallography.

Authors: Orth P Xiao L Hernandez LD et al.

Source: The Journal of biological chemistry [J Biol Chem] 2014 Jun 27; Vol. 289 (26), pp. 18008-21. Date of Electronic Publication: 2014 May 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Affinity characterization-mass spectrometry methodology for quantitative analyses of small molecule protein binding in solution.

Authors: Vilenchik LZ Sheth PR Chuang CC et al.

Source: Analytical biochemistry [Anal Biochem] 2011 Nov 01; Vol. 418 (1), pp. 10-8. Date of Electronic Publication: 2011 Jun 13.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0309 (Electronic) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

Fully activated MEK1 exhibits compromised affinity for binding of allosteric inhibitors U0126 and PD0325901.

Authors: Sheth PR Liu Y Hesson T et al.

Source: Biochemistry [Biochemistry] 2011 Sep 20; Vol. 50 (37), pp. 7964-76. Date of Electronic Publication: 2011 Aug 26.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Structural basis of CX-4945 binding to human protein kinase CK2.

Authors: Ferguson AD Sheth PR Basso AD et al.

Source: FEBS letters [FEBS Lett] 2011 Jan 03; Vol. 585 (1), pp. 104-10. Date of Electronic Publication: 2010 Nov 18.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: John Wiley & Sons Ltd Country of Publication: England NLM ID: 0155157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3468 (Electronic) Linking ISSN: 00145793 NLM ISO Abbreviation: FEBS Lett Subsets: MEDLINE

Expression, purification, stability optimization and characterization of human Aurora B kinase domain from E. coli.

Authors: Sheth PR Ramanathan L Ranchod A et al.

Source: Archives of biochemistry and biophysics [Arch Biochem Biophys] 2010 Nov 15; Vol. 503 (2), pp. 191-201. Date of Electronic Publication: 2010 Aug 10.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372430 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0384 (Electronic) Linking ISSN: 00039861 NLM ISO Abbreviation: Arch Biochem Biophys Subsets: MEDLINE

SCH 2047069, a novel oral kinesin spindle protein inhibitor, shows single-agent antitumor activity and enhances the efficacy of chemotherapeutics.

Authors: Basso AD Liu M Dai C et al.

Source: Molecular cancer therapeutics [Mol Cancer Ther] 2010 Nov; Vol. 9 (11), pp. 2993-3002. Date of Electronic Publication: 2010 Oct 26.

Publication Type: Journal Article

Journal Info: Publisher: American Association for Cancer Research, Inc Country of Publication: United States NLM ID: 101132535 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-8514 (Electronic) Linking ISSN: 15357163 NLM ISO Abbreviation: Mol Cancer Ther Subsets: MEDLINE