Search Results - "Shultz MD"

Transaminases Provide Key Chiral Building Blocks for the Synthesis of Selective M1/M4 Agonists.

Authors: Thomson CG Boss K Calhoun A et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2023 Nov 06; Vol. 14 (12), pp. 1692-1699. Date of Electronic Publication: 2023 Nov 06 (Print Publication: 2023).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Evolution of Novartis' Small Molecule Screening Deck Design.

Authors: Schuffenhauer A Schneider N Hintermann S et al.

Source: Journal of medicinal chemistry [J Med Chem] 2020 Dec 10; Vol. 63 (23), pp. 14425-14447. Date of Electronic Publication: 2020 Nov 03.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Identification of TNO155, an Allosteric SHP2 Inhibitor for the Treatment of Cancer.

Authors: LaMarche MJ Acker M Argintaru A et al.

Source: Journal of medicinal chemistry [J Med Chem] 2020 Nov 25; Vol. 63 (22), pp. 13578-13594. Date of Electronic Publication: 2020 Sep 24.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Correction to Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.

Authors: Bagdanoff JT Chen Z Acker M et al.

Source: Journal of medicinal chemistry [J Med Chem] 2019 Apr 11; Vol. 62 (7), pp. 3780. Date of Electronic Publication: 2019 Mar 22.

Publication Type: Journal Article; Published Erratum

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: PubMed not MEDLINE

Correction to 6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.

Authors: Sarver P Acker M Bagdanoff JT et al.

Source: Journal of medicinal chemistry [J Med Chem] 2019 Apr 11; Vol. 62 (7), pp. 3781. Date of Electronic Publication: 2019 Mar 22.

Publication Type: Journal Article; Published Erratum

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: PubMed not MEDLINE

Two Decades under the Influence of the Rule of Five and the Changing Properties of Approved Oral Drugs.

Authors: Shultz MD; Global Discovery Chemistry , Novartis Institutes for Biomedical Research, Inc. , 181 Massachusetts Avenue , Cambridge , Massachusetts 02139 , United States.

Source: Journal of medicinal chemistry [J Med Chem] 2019 Feb 28; Vol. 62 (4), pp. 1701-1714. Date of Electronic Publication: 2018 Sep 27.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Dual Allosteric Inhibition of SHP2 Phosphatase.

Authors: Fodor M Price E Wang P et al.

Source: ACS chemical biology [ACS Chem Biol] 2018 Mar 16; Vol. 13 (3), pp. 647-656. Date of Electronic Publication: 2018 Jan 18.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.

Authors: Huang Y Zhang J Yu Z et al.

Source: Journal of medicinal chemistry [J Med Chem] 2017 Mar 23; Vol. 60 (6), pp. 2215-2226. Date of Electronic Publication: 2017 Feb 06.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Structure-Guided Design of EED Binders Allosterically Inhibiting the Epigenetic Polycomb Repressive Complex 2 (PRC2) Methyltransferase.

Authors: Lingel A Sendzik M Huang Y et al.

Source: Journal of medicinal chemistry [J Med Chem] 2017 Jan 12; Vol. 60 (1), pp. 415-427. Date of Electronic Publication: 2017 Jan 03.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Melanoma Differentiation-associated Gene 7/IL-24 Exerts Cytotoxic Effects by Altering the Alternative Splicing of Bcl-x Pre-mRNA via the SRC/PKCδ Signaling Axis.

Authors: Shapiro BA Vu NT Shultz MD et al.

Source: The Journal of biological chemistry [J Biol Chem] 2016 Oct 07; Vol. 291 (41), pp. 21669-21681. Date of Electronic Publication: 2016 Aug 12.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor.

Authors: Garcia Fortanet J Chen CH Chen YN et al.

Source: Journal of medicinal chemistry [J Med Chem] 2016 Sep 08; Vol. 59 (17), pp. 7773-82. Date of Electronic Publication: 2016 Jul 12.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases.

Authors: Chen YN LaMarche MJ Chan HM et al.

Source: Nature [Nature] 2016 Jul 07; Vol. 535 (7610), pp. 148-52. Date of Electronic Publication: 2016 Jun 29.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis.

Authors: Vu NT Park MA Shultz MD et al.

Source: Cancer research [Cancer Res] 2016 May 15; Vol. 76 (10), pp. 2977-89. Date of Electronic Publication: 2016 Mar 29.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for Cancer Research Country of Publication: United States NLM ID: 2984705R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1538-7445 (Electronic) Linking ISSN: 00085472 NLM ISO Abbreviation: Cancer Res Subsets: MEDLINE

Modified Seed Growth of Iron Oxide Nanoparticles in Benzyl Alcohol - Optimization for Heating and Broad Stability in Biomedical Applications.

Authors: Gilliland SE 3rd Carpenter EE Shultz MD

Source: Nanobiomedicine [Nanobiomedicine (Rij)] 2014 Jan 01; Vol. 1, pp. 9. Date of Electronic Publication: 2014 Jan 01 (Print Publication: 2014).

Publication Type: Journal Article

Journal Info: Publisher: Sage Publications Country of Publication: England NLM ID: 101667896 Publication Model: eCollection Cited Medium: Internet ISSN: 1849-5435 (Electronic) Linking ISSN: 18495435 NLM ISO Abbreviation: Nanobiomedicine (Rij) Subsets: PubMed not MEDLINE

Improving the plausibility of success with inefficient metrics.

Authors: Shultz MD; Novartis Institutes for Biomedical Research, Inc. , 250 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2013 Nov 21; Vol. 5 (1), pp. 2-5. Date of Electronic Publication: 2013 Nov 21 (Print Publication: 2014).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Metallofullerenes: a new class of MRI agents and more?

Authors: Fatouros PP Shultz MD

Source: Nanomedicine (London, England) [Nanomedicine (Lond)] 2013 Nov; Vol. 8 (11), pp. 1853-64.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Taylor & Francis Country of Publication: England NLM ID: 101278111 Publication Model: Print Cited Medium: Internet ISSN: 1748-6963 (Electronic) Linking ISSN: 17435889 NLM ISO Abbreviation: Nanomedicine (Lond) Subsets: MEDLINE

Setting expectations in molecular optimizations: Strengths and limitations of commonly used composite parameters.

Authors: Shultz MD; Novartis Institutes for Biomedical Research, Inc., 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: michael.shultz@novartis.com.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Nov 01; Vol. 23 (21), pp. 5980-91. Date of Electronic Publication: 2013 Aug 13.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

The thermodynamic basis for the use of lipophilic efficiency (LipE) in enthalpic optimizations.

Authors: Shultz MD; Novartis Institutes for Biomedical Research, Inc., 250 Massachusetts Avenue, Cambridge, MA 02139, USA. Electronic address: michael.shultz@novartis.com.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2013 Nov 01; Vol. 23 (21), pp. 5992-6000. Date of Electronic Publication: 2013 Aug 14.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases.

Authors: Shultz MD Majumdar D Chin DN et al.

Source: Journal of medicinal chemistry [J Med Chem] 2013 Sep 12; Vol. 56 (17), pp. 7049-59. Date of Electronic Publication: 2013 Aug 14.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor.

Authors: Shultz MD Cheung AK Kirby CA et al.

Source: Journal of medicinal chemistry [J Med Chem] 2013 Aug 22; Vol. 56 (16), pp. 6495-511. Date of Electronic Publication: 2013 Aug 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE