Search Results - "Solodenko J"

A comparative computational analysis of IFN-alpha pharmacokinetics and its induced cellular response in mice and humans.

Authors: Kalra, Priyata Kister, Bastian Fendt, Rebekka et al.

Source: PLoS Computational Biology. 9/25/2025, Vol. 21 Issue 9, p1-18. 18p.

Target-Controlled Infusion for Caesarean Delivery Under General Anesthesia: From Conventional Pharmacokinetic Models to Physiologically Based Pharmacokinetic Modeling.

Authors: Keresztes, Matild Azamfirei, Leonard Almasy, Emoke et al.

Source: Life (2075-1729). May2026, Vol. 16 Issue 5, p739. 18p.

Physiologically Based Biopharmaceutics Modelling—Best Scientific Practices to Define Drug Product Performance, Latest Regulatory and Industry Perspectives: Workshop Summary Report.

Authors: McAllister, Mark Mistry, Nena Pepin, Xavier et al.

Source: Pharmaceutics. May2026, Vol. 18 Issue 5, p566. 36p.

Development of a novel physiologically based biopharmaceutics modeling (PBBM) framework using the open systems pharmacology suite, part 2: in vivo pharmacokinetic modeling of vericiguat.

Authors: Vrenken P Vertzoni M Frechen S et al.

Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Sep 01; Vol. 212, pp. 107189. Date of Electronic Publication: 2025 Jul 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

Development of a novel physiologically based biopharmaceutics modeling (PBBM) framework using the open systems pharmacology suite, part 1: in vitro modeling of vericiguat.

Authors: Vrenken P Vertzoni M Frechen S et al.

Source: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences [Eur J Pharm Sci] 2025 Sep 01; Vol. 212, pp. 107164. Date of Electronic Publication: 2025 Jun 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science B.V Country of Publication: Netherlands NLM ID: 9317982 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0720 (Electronic) Linking ISSN: 09280987 NLM ISO Abbreviation: Eur J Pharm Sci Subsets: MEDLINE

Targeting Melanin Production: The Safety of Tyrosinase Inhibition.

Authors: Erler, Steffen Kolbe, Ludger Najjar, Abdulkarim et al.

Source: International Journal of Molecular Sciences. Jan2026, Vol. 27 Issue 1, p97. 18p.

Multi-scale computational modeling towards efficacy in radiopharmaceutical therapies while minimizing side effects: Modeling of amino acid infusion.

Authors: Golzaryan, Aryan Souri, Mohammad Kashkooli, Farshad M. et al.

Source: PLoS Computational Biology. 7/16/2025, Vol. 21 Issue 7, p1-38. 38p.

Developmental Programming of Drug Response: Microbiota as a Missing Dimension in Perinatal Drug Discovery.

Authors: Zhang, Yanan Ma, Liangkun Wang, Yan

Source: International Journal of Molecular Sciences. Jun2026, Vol. 27 Issue 11, p4667. 24p.

Whole-Body Physiologically Based Pharmacokinetic Modeling Framework for Tissue Target Engagement of CD3 Bispecific Antibodies.

Authors: Susilo, Monica E. Schaller, Stephan Jiménez-Franco, Luis David et al.

Source: Pharmaceutics. Apr2025, Vol. 17 Issue 4, p500. 18p.

A minimal physiologically‐based pharmacokinetic modeling platform to predict intratumor exposure and receptor occupancy of an anti‐LAG‐3 monoclonal antibody.

Authors: Michelet, Robin Petersson, Klas Huisman, Marc C. et al.

Source: CPT: Pharmacometrics & Systems Pharmacology. Mar2025, Vol. 14 Issue 3, p460-473. 14p.

Assessing Drug–Drug Interaction and Food Effect for BCS Class 2 Compound BI 730357 (Retinoic Acid-Related Orphan Receptor Gamma Antagonist, Bevurogant) Using a Physiology-Based Pharmacokinetics Modeling (PBPK) Approach with Semi-Mechanistic Absorption

Authors: Kanacher, Tobias Sjögren, Erik Korell, Julia et al.

Source: Pharmaceutics. Mar2025, Vol. 17 Issue 3, p314. 16p.

Optimization of pediatric dosing regimens for aztreonam and amoxicillin/clavulanate combination therapy against multidrug-resistant bacteria.

Authors: Wang L Wu M Qu L et al.

Source: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2026 Jun; Vol. 45 (6), pp. 1763-1783. Date of Electronic Publication: 2026 Mar 10.

Publication Type: Journal Article

Journal Info: Publisher: Springer Country of Publication: Germany NLM ID: 8804297 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1435-4373 (Electronic) Linking ISSN: 09349723 NLM ISO Abbreviation: Eur J Clin Microbiol Infect Dis Subsets: MEDLINE; In Process

PBPK modeling of recombinant factor IX Fc fusion protein (rFIXFc) and rFIX to characterize the binding to type 4 collagen in the extravascular space.

Authors: Cloesmeijer, Michael E. Sjögren, Erik Koopman, Sjoerd F. et al.

Source: CPT: Pharmacometrics & Systems Pharmacology. Oct2024, Vol. 13 Issue 10, p1630-1640. 11p.

A physiologically based pharmacokinetic model to optimize the dosage regimen and withdrawal time of cefquinome in pigs.

Authors: Mi, Kun Sun, Lei Hou, Yixuan et al.

Source: PLoS Computational Biology. 8/16/2023, Vol. 19 Issue 8, p1-19. 19p.

Population Pharmacokinetic/Pharmacodynamic Modeling of Therapeutic Enzymes in Lysosomal Storage Diseases.

Authors: Barzel I van der Ploeg AT Pijnappel WWMP et al.

Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2026 May; Vol. 65 (5), pp. 647-664. Date of Electronic Publication: 2026 May 08.

Publication Type: Journal Article; Review; Systematic Review

Journal Info: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE

Predicting Cumulative Neonatal Sodium Benzoate Exposures During Breastfeeding with Physiologically Based Pharmacokinetic Modelling.

Authors: Wang S Hamadeh A Mian P et al.

Source: Clinical pharmacokinetics [Clin Pharmacokinet] 2026 May; Vol. 65 (5), pp. 665-680. Date of Electronic Publication: 2026 Feb 27.

Publication Type: Journal Article

Journal Info: Publisher: Country of Publication: Switzerland NLM ID: 7606849 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1179-1926 (Electronic) Linking ISSN: 03125963 NLM ISO Abbreviation: Clin Pharmacokinet Subsets: MEDLINE

Differences in Physiologically Based Pharmacokinetic Predictions between Software Platforms Can Be Clinically Relevant: Cases of Levornestrogel and Ethinylestradiol Concentrations with SIMCYP versus PK-Sim from a User Perspective.

Authors: Massaux C Dogné JM Musuamba FT

Source: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2026 May; Vol. 51 (3), pp. 247-268. Date of Electronic Publication: 2026 Apr 04.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Springer France Country of Publication: France NLM ID: 7608491 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2107-0180 (Electronic) Linking ISSN: 03787966 NLM ISO Abbreviation: Eur J Drug Metab Pharmacokinet Subsets: MEDLINE

Mirtazapine is a functional antagonist at cardiac human H1-histamine receptors.

Authors: Pham TH Schlicht JMA Hofmann B et al.

Source: Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 2026 Mar; Vol. 399 (6), pp. 8061-8074. Date of Electronic Publication: 2025 Dec 20.

Publication Type: Journal Article

Journal Info: Publisher: Springer Verlag Country of Publication: Germany NLM ID: 0326264 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1432-1912 (Electronic) Linking ISSN: 00281298 NLM ISO Abbreviation: Naunyn Schmiedebergs Arch Pharmacol Subsets: MEDLINE

Defining Safe and Effective Cefazolin Dosing Regimens for MSSA Infections in the CNS: Leveraging Sparse Real-World Data and PBPK Modeling.

Authors: Dubinsky S McIntyre M Kim MS et al.

Source: European journal of drug metabolism and pharmacokinetics [Eur J Drug Metab Pharmacokinet] 2026 Mar; Vol. 51 (2), pp. 193-204. Date of Electronic Publication: 2026 Feb 05.

Publication Type: Journal Article

Journal Info: Publisher: Springer France Country of Publication: France NLM ID: 7608491 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2107-0180 (Electronic) Linking ISSN: 03787966 NLM ISO Abbreviation: Eur J Drug Metab Pharmacokinet Subsets: MEDLINE

A Comprehensive Physiologically Based Pharmacokinetic Framework of Ofloxacin: Predicting Disposition in Renal Impairment.

Authors: Zamir, Ammara Rasool, Muhammad Fawad Hussain, Iltaf et al.

Source: Pharmaceutics. Sep2025, Vol. 17 Issue 9, p1224. 16p.