Search Results - "Springman E"

62 Correlated changes in inflammation biomarkers from a phase 1 study of acebilustat in adult cystic fibrosis patients.

Authors: Springman, E. Ahuja, S. Bhatt, L. et al.

Source: Journal of Cystic Fibrosis. Jun2017 Supplement 1, Vol. 16, pS80-S80. 1p.

127 Pharmacokinetic and pharmacodynamic profile of CTX-4430 in two phase 1 studies.

Authors: Springman, E. Bhatt, L. Grosswald, R. et al.

Source: Journal of Cystic Fibrosis. Jun2015 Supplement 1, Vol. 14, pS90-S90. 1p.

126 A phase 1 clinical study of CTX-4430 in cystic fibrosis patients.

Authors: Springman, E. Grosswald, R. Philpot, E. et al.

Source: Journal of Cystic Fibrosis. Jun2015 Supplement 1, Vol. 14, pS90-S90. 1p.

129 A phase 1 drug-drug interaction study of CTX-4430 assessing CYP3A4 induction.

Authors: Ahuja, S. Grosswald, R. Christ, D. et al.

Source: Journal of Cystic Fibrosis. Jun2015 Supplement 1, Vol. 14, pS90-S90. 1p.

Evaluation of Acebilustat, a Selective Inhibitor of Leukotriene B4 Biosynthesis, for Treatment of Outpatients With Mild-Moderate Coronavirus Disease 2019: A Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial.

Authors: Levitt JE Hedlin H Duong S et al.

Source: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America [Clin Infect Dis] 2023 Jul 26; Vol. 77 (2), pp. 186-193.

Publication Type: Randomized Controlled Trial; Clinical Trial, Phase II; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 9203213 Publication Model: Print Cited Medium: Internet ISSN: 1537-6591 (Electronic) Linking ISSN: 10584838 NLM ISO Abbreviation: Clin Infect Dis Subsets: MEDLINE

Distinct compartmentalization of immune cells and mediators characterizes bullous pemphigoid disease.

Authors: Margaroli C Bradley B Thompson C et al.

Source: Experimental dermatology [Exp Dermatol] 2020 Dec; Vol. 29 (12), pp. 1191-1198. Date of Electronic Publication: 2020 Oct 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Munksgaard Country of Publication: Denmark NLM ID: 9301549 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1600-0625 (Electronic) Linking ISSN: 09066705 NLM ISO Abbreviation: Exp Dermatol Subsets: MEDLINE

Empire-CF study: A phase 2 clinical trial of leukotriene A4 hydrolase inhibitor acebilustat in adult subjects with cystic fibrosis.

Authors: Elborn JS Konstan MW Taylor-Cousar JL et al.

Corporate Authors: Elborn JS Konstan MW Taylor-Cousar JL et al.

Source: Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society [J Cyst Fibros] 2021 Nov; Vol. 20 (6), pp. 1026-1034. Date of Electronic Publication: 2021 Sep 17.

Publication Type: Clinical Trial, Phase II; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101128966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-5010 (Electronic) Linking ISSN: 15691993 NLM ISO Abbreviation: J Cyst Fibros Subsets: MEDLINE

The COVID-19 Outpatient Pragmatic Platform Study (COPPS): Study design of a multi-center pragmatic platform trial.

Authors: Bunning B Hedlin H Purington N et al.

Source: Contemporary clinical trials [Contemp Clin Trials] 2021 Sep; Vol. 108, pp. 106509. Date of Electronic Publication: 2021 Jul 16.

Publication Type: Clinical Trial Protocol; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101242342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-2030 (Electronic) Linking ISSN: 15517144 NLM ISO Abbreviation: Contemp Clin Trials Subsets: MEDLINE

Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction.

Authors: Elborn JS Bhatt L Grosswald R et al.

Source: Clinical and translational science [Clin Transl Sci] 2017 Jan; Vol. 10 (1), pp. 20-27. Date of Electronic Publication: 2016 Oct 28.

Publication Type: Clinical Trial, Phase I; Journal Article

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis.

Authors: Elborn JS Horsley A MacGregor G et al.

Source: Clinical and translational science [Clin Transl Sci] 2017 Jan; Vol. 10 (1), pp. 28-34. Date of Electronic Publication: 2016 Nov 02.

Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial

Journal Info: Publisher: WileyBlackwell Pub Country of Publication: United States NLM ID: 101474067 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1752-8062 (Electronic) Linking ISSN: 17528054 NLM ISO Abbreviation: Clin Transl Sci Subsets: MEDLINE

Antiangiogenic and antitumor activity of LP-261, a novel oral tubulin binding agent, alone and in combination with bevacizumab.

Authors: Gardner ER Kelly M Springman E et al.

Source: Investigational new drugs [Invest New Drugs] 2012 Feb; Vol. 30 (1), pp. 90-7. Date of Electronic Publication: 2010 Sep 07.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural

Journal Info: Publisher: Springer Country of Publication: United States NLM ID: 8309330 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-0646 (Electronic) Linking ISSN: 01676997 NLM ISO Abbreviation: Invest New Drugs Subsets: MEDLINE

EMPIRE-CF: A phase II randomized placebo-controlled trial of once-daily, oral acebilustat in adult patients with cystic fibrosis - Study design and patient demographics.

Authors: Elborn JS Ahuja S Springman E et al.

Source: Contemporary clinical trials [Contemp Clin Trials] 2018 Sep; Vol. 72, pp. 86-94. Date of Electronic Publication: 2018 Jul 26.

Publication Type: Clinical Trial Protocol; Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 101242342 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-2030 (Electronic) Linking ISSN: 15517144 NLM ISO Abbreviation: Contemp Clin Trials Subsets: MEDLINE

Recent advances in clinical development of leukotriene B4 pathway drugs.

Authors: Bhatt L Roinestad K Van T et al.

Source: Seminars in immunology [Semin Immunol] 2017 Oct; Vol. 33, pp. 65-73.

Publication Type: Journal Article; Review

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9009458 Publication Model: Print Cited Medium: Internet ISSN: 1096-3618 (Electronic) Linking ISSN: 10445323 NLM ISO Abbreviation: Semin Immunol Subsets: MEDLINE

Discovery of a novel class of non-ATP site DFG-out state p38 inhibitors utilizing computationally assisted virtual fragment-based drug design (vFBDD).

Authors: Moffett K Konteatis Z Nguyen D et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Dec 01; Vol. 21 (23), pp. 7155-65. Date of Electronic Publication: 2011 Sep 28.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Expression, crystallization, and three-dimensional structure of the catalytic domain of human plasma kallikrein.

Authors: Tang J Yu CL Williams SR et al.

Source: The Journal of biological chemistry [J Biol Chem] 2005 Dec 09; Vol. 280 (49), pp. 41077-89. Date of Electronic Publication: 2005 Sep 30.

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K.

Authors: Palmer JT Bryant C Wang DX et al.

Source: Journal of medicinal chemistry [J Med Chem] 2005 Dec 01; Vol. 48 (24), pp. 7520-34.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Improved expression, purification, and crystallization of p38alpha MAP kinase.

Authors: Bukhtiyarova M Northrop K Chai X et al.

Source: Protein expression and purification [Protein Expr Purif] 2004 Sep; Vol. 37 (1), pp. 154-61.

Publication Type: Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print Cited Medium: Print ISSN: 1046-5928 (Print) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE

Expression and characterization of human tissue kallikrein variants.

Authors: Chan H Springman EB Clark JM

Source: Protein expression and purification [Protein Expr Purif] 1998 Apr; Vol. 12 (3), pp. 361-70.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print Cited Medium: Print ISSN: 1046-5928 (Print) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE

Crystal structure of recombinant human tissue kallikrein at 2.0 A resolution.

Authors: Katz BA Liu B Barnes M et al.

Source: Protein science : a publication of the Protein Society [Protein Sci] 1998 Apr; Vol. 7 (4), pp. 875-85.

Publication Type: Journal Article

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Print ISSN: 0961-8368 (Print) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

Zinc content and function in human fibroblast collagenase.

Authors: Springman EB Nagase H Birkedal-Hansen H et al.

Source: Biochemistry [Biochemistry] 1995 Dec 05; Vol. 34 (48), pp. 15713-20.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Print ISSN: 0006-2960 (Print) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE