Search Results - "Springman EB"

Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction.

Authors: Elborn, JS Bhatt, L Grosswald, R et al.

Source: CTS: Clinical & Translational Science. Jan2017, Vol. 10 Issue 1, p20-27. 8p.

Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis.

Authors: Elborn, JS Horsley, A MacGregor, G et al.

Source: CTS: Clinical & Translational Science. Jan2017, Vol. 10 Issue 1, p28-34. 7p.

Recent advances in clinical development of leukotriene B4 pathway drugs.

Authors: Bhatt L Roinestad K Van T et al.

Source: Seminars in immunology [Semin Immunol] 2017 Oct; Vol. 33, pp. 65-73.

Publication Type: Journal Article; Review

Journal Info: Publisher: Academic Press Country of Publication: England NLM ID: 9009458 Publication Model: Print Cited Medium: Internet ISSN: 1096-3618 (Electronic) Linking ISSN: 10445323 NLM ISO Abbreviation: Semin Immunol Subsets: MEDLINE

Synthesis and pharmacological evaluation of N-(3-(1H-indol-4-yl)-5-(2-methoxyisonicotinoyl)phenyl)methanesulfonamide (LP-261), a potent antimitotic agent.

Authors: Shetty RS Lee Y Liu B et al.

Source: Journal of medicinal chemistry [J Med Chem] 2011 Jan 13; Vol. 54 (1), pp. 179-200. Date of Electronic Publication: 2010 Dec 02.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery and SAR of a series of 4,6-diamino-1,3,5-triazin-2-ol as novel non-nucleoside reverse transcriptase inhibitors of HIV-1.

Authors: Liu B Lee Y Zou J et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Nov 15; Vol. 20 (22), pp. 6592-6. Date of Electronic Publication: 2010 Sep 21.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Analysis of imatinib and sorafenib binding to p38alpha compared with c-Abl and b-Raf provides structural insights for understanding the selectivity of inhibitors targeting the DFG-out form of protein kinases.

Authors: Namboodiri HV Bukhtiyarova M Ramcharan J et al.

Source: Biochemistry [Biochemistry] 2010 May 04; Vol. 49 (17), pp. 3611-8.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Structure-based design of substituted biphenyl ethylene ethers as ligands binding in the hydrophobic pocket of gp41 and blocking the helical bundle formation.

Authors: Liu B Joseph RW Dorsey BD et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2009 Oct 01; Vol. 19 (19), pp. 5693-7. Date of Electronic Publication: 2009 Aug 08.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Mutagenesis of p38alpha MAP kinase establishes key roles of Phe169 in function and structural dynamics and reveals a novel DFG-OUT state.

Authors: Bukhtiyarova M Karpusas M Northrop K et al.

Source: Biochemistry [Biochemistry] 2007 May 15; Vol. 46 (19), pp. 5687-96. Date of Electronic Publication: 2007 Apr 19.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0006-2960 (Print) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Two classes of p38alpha MAP kinase inhibitors having a common diphenylether core but exhibiting divergent binding modes.

Authors: Michelotti EL Moffett KK Nguyen D et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2005 Dec 01; Vol. 15 (23), pp. 5274-9. Date of Electronic Publication: 2005 Sep 19.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

A Biacore biosensor method for detailed kinetic binding analysis of small molecule inhibitors of p38alpha mitogen-activated protein kinase.

Authors: Casper D Bukhtiyarova M Springman EB

Source: Analytical biochemistry [Anal Biochem] 2004 Feb 01; Vol. 325 (1), pp. 126-36.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0370535 Publication Model: Print Cited Medium: Print ISSN: 0003-2697 (Print) Linking ISSN: 00032697 NLM ISO Abbreviation: Anal Biochem Subsets: MEDLINE

Amino acid derived sulfonamide hydroxamates as inhibitors of procollagen C-proteinase. Part 2: Solid-phase optimization of side chains.

Authors: Dankwardt SM Abbot SC Broka CA et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2002 Apr 22; Vol. 12 (8), pp. 1233-5.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Expression and characterization of human tissue kallikrein variants.

Authors: Chan H Springman EB Clark JM

Source: Protein expression and purification [Protein Expr Purif] 1998 Apr; Vol. 12 (3), pp. 361-70.

Publication Type: Comparative Study; Journal Article

Journal Info: Publisher: Academic Press Country of Publication: United States NLM ID: 9101496 Publication Model: Print Cited Medium: Print ISSN: 1046-5928 (Print) Linking ISSN: 10465928 NLM ISO Abbreviation: Protein Expr Purif Subsets: MEDLINE

Crystal structure of recombinant human tissue kallikrein at 2.0 A resolution.

Authors: Katz BA Liu B Barnes M et al.

Source: Protein science : a publication of the Protein Society [Protein Sci] 1998 Apr; Vol. 7 (4), pp. 875-85.

Publication Type: Journal Article

Journal Info: Publisher: Cold Spring Harbor Laboratory Press Country of Publication: United States NLM ID: 9211750 Publication Model: Print Cited Medium: Print ISSN: 0961-8368 (Print) Linking ISSN: 09618368 NLM ISO Abbreviation: Protein Sci Subsets: MEDLINE

Zinc content and function in human fibroblast collagenase.

Authors: Springman EB Nagase H Birkedal-Hansen H et al.

Source: Biochemistry [Biochemistry] 1995 Dec 05; Vol. 34 (48), pp. 15713-20.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print Cited Medium: Print ISSN: 0006-2960 (Print) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Mast cell procarboxypeptidase A. Molecular modeling and biochemical characterization of its processing within secretory granules.

Authors: Springman EB Dikov MM Serafin WE

Source: The Journal of biological chemistry [J Biol Chem] 1995 Jan 20; Vol. 270 (3), pp. 1300-7.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Processing of procarboxypeptidase A and other zymogens in murine mast cells.

Authors: Dikov MM Springman EB Yeola S et al.

Source: The Journal of biological chemistry [J Biol Chem] 1994 Oct 14; Vol. 269 (41), pp. 25897-904.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print Cited Medium: Print ISSN: 0021-9258 (Print) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Biochemical basis for multiple modes of activation of human fibroblast collagenase.

Authors: Springman EB Angleton EL Birkedal-Hansen H et al.

Source: Matrix (Stuttgart, Germany). Supplement [Matrix Suppl] 1992; Vol. 1, pp. 76-7.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: Gustav Fischer Verlag Country of Publication: Germany NLM ID: 9312140 Publication Model: Print Cited Medium: Print ISSN: 0940-1199 (Print) Linking ISSN: 09401199 NLM ISO Abbreviation: Matrix Suppl Subsets: MEDLINE

Multiple modes of activation of latent human fibroblast collagenase: evidence for the role of a Cys73 active-site zinc complex in latency and a "cysteine switch" mechanism for activation.

Authors: Springman EB Angleton EL Birkedal-Hansen H et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 1990 Jan; Vol. 87 (1), pp. 364-8.

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Print ISSN: 0027-8424 (Print) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE