Search Results - "Stepan AF"

Enhancing Drug Discovery and Development through the Integration of Medicinal Chemistry, Chemical Biology, and Academia-Industry Partnerships: Insights from Roche's Endocannabinoid System Projects.

Authors: Aebi J Atz K Ametamey SM et al.

Source: Chimia [Chimia (Aarau)] 2024 Aug 21; Vol. 78 (7-8), pp. 499-512. Date of Electronic Publication: 2024 Aug 21.

Publication Type: Journal Article

Journal Info: Publisher: Swiss Chemical Society Country of Publication: Switzerland NLM ID: 0373152 Publication Model: Electronic Cited Medium: Print ISSN: 0009-4293 (Print) Linking ISSN: 00094293 NLM ISO Abbreviation: Chimia (Aarau) Subsets: MEDLINE

The "five-star matrix" for patient-centric drug discovery and development in neuroscience.

Authors: Pähler A O'Connor EC Binch H et al.

Source: Neuron [Neuron] 2025 Sep 17; Vol. 113 (18), pp. 2885-2909. Date of Electronic Publication: 2025 Sep 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 8809320 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4199 (Electronic) Linking ISSN: 08966273 NLM ISO Abbreviation: Neuron Subsets: MEDLINE

Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.

Authors: Pettersson M Johnson DS Humphrey JM et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Jun 27; Vol. 67 (12), pp. 10248-10262. Date of Electronic Publication: 2024 Jun 07.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

The 2^nd Alpine Winter Conference on Medicinal and Synthetic Chemistry.

Authors: Ciulli A Hamann L Jahnke W et al.

Source: ChemMedChem [ChemMedChem] 2021 Aug 05; Vol. 16 (15), pp. 2417-2423. Date of Electronic Publication: 2021 Jun 10.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Enabling late-stage drug diversification by high-throughput experimentation with geometric deep learning.

Authors: Nippa DF Atz K Hohler R et al.

Source: Nature chemistry [Nat Chem] 2024 Feb; Vol. 16 (2), pp. 239-248. Date of Electronic Publication: 2023 Nov 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101499734 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1755-4349 (Electronic) Linking ISSN: 17554330 NLM ISO Abbreviation: Nat Chem Subsets: MEDLINE

LRRK2 activation in idiopathic Parkinson's disease.

Authors: Di Maio R Hoffman EK Rocha EM et al.

Source: Science translational medicine [Sci Transl Med] 2018 Jul 25; Vol. 10 (451).

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101505086 Publication Model: Print Cited Medium: Internet ISSN: 1946-6242 (Electronic) Linking ISSN: 19466234 NLM ISO Abbreviation: Sci Transl Med Subsets: MEDLINE

LipMetE (Lipophilic Metabolism Efficiency) as a Simple Guide for Half-Life and Dosing Regimen Prediction of Oral Drugs.

Authors: Cecere G Guasch L Olivares-Morales AM et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Aug 23; Vol. 13 (9), pp. 1444-1451. Date of Electronic Publication: 2022 Aug 23 (Print Publication: 2022).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Small-Molecule Lead-Finding Trends across the Roche and Genentech Research Organizations.

Authors: Dragovich PS Haap W Mulvihill MM et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Feb 24; Vol. 65 (4), pp. 3606-3615. Date of Electronic Publication: 2022 Feb 09.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Synthesis and Biopharmaceutical Evaluation of Imatinib Analogues Featuring Unusual Structural Motifs.

Authors: Nicolaou KC Vourloumis D Totokotsopoulos S et al.

Source: ChemMedChem [ChemMedChem] 2016 Jan 05; Vol. 11 (1), pp. 31-7. Date of Electronic Publication: 2015 Nov 20.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Country of Publication: Germany NLM ID: 101259013 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1860-7187 (Electronic) Linking ISSN: 18607179 NLM ISO Abbreviation: ChemMedChem Subsets: MEDLINE

Phenyl bioisosteres in medicinal chemistry: discovery of novel γ-secretase modulators as a potential treatment for Alzheimer's disease.

Authors: Ratni H Baumann K Bellotti P et al.

Source: RSC medicinal chemistry [RSC Med Chem] 2021 Apr 12; Vol. 12 (5), pp. 758-766. Date of Electronic Publication: 2021 Apr 12 (Print Publication: 2021).

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101759460 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-8682 (Electronic) Linking ISSN: 26328682 NLM ISO Abbreviation: RSC Med Chem Subsets: PubMed not MEDLINE

Synthesis and applications of highly functionalized 1-halo-3-substituted bicyclo[1.1.1]pentanes.

Authors: Caputo DFJ Arroniz C Dürr AB et al.

Source: Chemical science [Chem Sci] 2018 May 21; Vol. 9 (23), pp. 5295-5300. Date of Electronic Publication: 2018 May 21 (Print Publication: 2018).

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101545951 Publication Model: eCollection Cited Medium: Print ISSN: 2041-6520 (Print) Linking ISSN: 20416520 NLM ISO Abbreviation: Chem Sci Subsets: PubMed not MEDLINE

Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors.

Authors: Obach RS Walker GS Sharma R et al.

Source: Journal of medicinal chemistry [J Med Chem] 2018 Apr 26; Vol. 61 (8), pp. 3626-3640. Date of Electronic Publication: 2018 Apr 09.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Late-Stage Microsomal Oxidation Reduces Drug-Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189.

Authors: Stepan AF Tran TP Helal CJ et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2018 Jan 04; Vol. 9 (2), pp. 68-72. Date of Electronic Publication: 2018 Jan 04 (Print Publication: 2018).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Discovery and Characterization of (R)-6-Neopentyl-2-(pyridin-2-ylmethoxy)-6,7-dihydropyrimido[2,1-c][1,4]oxazin-4(9H)-one (PF-06462894), an Alkyne-Lacking Metabotropic Glutamate Receptor 5 Negative Allosteric Modulator Profiled in both Rat and Nonhuman Primates.

Authors: Stepan AF Claffey MM Reese MR et al.

Source: Journal of medicinal chemistry [J Med Chem] 2017 Sep 28; Vol. 60 (18), pp. 7764-7780. Date of Electronic Publication: 2017 Sep 13.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Mechanisms of Skin Toxicity Associated with Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators.

Authors: Shah F Stepan AF O'Mahony A et al.

Source: Cell chemical biology [Cell Chem Biol] 2017 Jul 20; Vol. 24 (7), pp. 858-869.e5. Date of Electronic Publication: 2017 Jun 29.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

A multi-endpoint matched molecular pair (MMP) analysis of 6-membered heterocycles.

Authors: Chang G Huard K Kauffman GW et al.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2017 Jan 01; Vol. 25 (1), pp. 381-388. Date of Electronic Publication: 2016 Nov 02.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.

Authors: Pettersson M Johnson DS Rankic DA et al.

Source: MedChemComm [Medchemcomm] 2016 Nov 02; Vol. 8 (4), pp. 730-743. Date of Electronic Publication: 2016 Nov 02 (Print Publication: 2017).

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101531525 Publication Model: eCollection Cited Medium: Print ISSN: 2040-2503 (Print) Linking ISSN: 20402503 NLM ISO Abbreviation: Medchemcomm Subsets: PubMed not MEDLINE

Oxidative diversification of amino acids and peptides by small-molecule iron catalysis.

Authors: Osberger TJ Rogness DC Kohrt JT et al.

Source: Nature [Nature] 2016 Sep 08; Vol. 537 (7619), pp. 214-219. Date of Electronic Publication: 2016 Aug 01.

Publication Type: Journal Article

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0410462 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4687 (Electronic) Linking ISSN: 00280836 NLM ISO Abbreviation: Nature Subsets: MEDLINE

Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.

Authors: Pettersson M Johnson DS Humphrey JM et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Apr 03; Vol. 6 (5), pp. 596-601. Date of Electronic Publication: 2015 Apr 03 (Print Publication: 2015).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.

Authors: Pettersson M Johnson DS Humphrey JM et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2015 Feb 15; Vol. 25 (4), pp. 908-13. Date of Electronic Publication: 2014 Dec 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE