Search Results - "Stepniewski TM"

GLP-1R and GIPR crosstalk modulates insulinotropic signaling pathways.

Authors: Lindquist P Dijkhof LRH Drzazga AK et al.

Source: Cell chemical biology [Cell Chem Biol] 2026 Jul 08. Date of Electronic Publication: 2026 Jul 08.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101676030 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2451-9448 (Electronic) Linking ISSN: 24519448 NLM ISO Abbreviation: Cell Chem Biol Subsets: MEDLINE

Molecular mechanisms of naturally encoded signaling bias at the complement anaphylatoxin receptors.

Authors: Tiwari D Sawada K Dalal A et al.

Source: Molecular cell [Mol Cell] 2026 Jul 02; Vol. 86 (13), pp. 2586-2604.e14. Date of Electronic Publication: 2026 Jun 22.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

An arginine switch drives the stepwise activation of β-arrestin by CXCR7.

Authors: Ji JS Yun Y Stepniewski TM et al.

Source: PLoS biology [PLoS Biol] 2025 Aug 07; Vol. 23 (8), pp. e3003312. Date of Electronic Publication: 2025 Aug 07 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101183755 Publication Model: eCollection Cited Medium: Internet ISSN: 1545-7885 (Electronic) Linking ISSN: 15449173 NLM ISO Abbreviation: PLoS Biol Subsets: MEDLINE

Relevance of G protein-coupled receptor (GPCR) dynamics for receptor activation, signalling bias and allosteric modulation.

Authors: Lopez-Balastegui M Stepniewski TM Kogut-Günthel MM et al.

Source: British journal of pharmacology [Br J Pharmacol] 2025 Jul; Vol. 182 (14), pp. 3211-3224. Date of Electronic Publication: 2024 Jul 08.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Altered desensitization and internalization patterns of rodent versus human glucose-dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge.

Authors: Gasbjerg LS Rasmussen RS Dragan A et al.

Source: British journal of pharmacology [Br J Pharmacol] 2025 Jul; Vol. 182 (14), pp. 3353-3370. Date of Electronic Publication: 2024 Jul 01.

Publication Type: Journal Article; Comparative Study

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Structural mechanism for noncanonical GPCR signaling in the Hedgehog pathway.

Authors: Steiner WP Iverson N Liu G et al.

Source: Nature structural & molecular biology [Nat Struct Mol Biol] 2026 May; Vol. 33 (5), pp. 795-809. Date of Electronic Publication: 2026 Apr 30.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: United States NLM ID: 101186374 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1545-9985 (Electronic) Linking ISSN: 15459985 NLM ISO Abbreviation: Nat Struct Mol Biol Subsets: MEDLINE

Rare variant in intracellular loop-2 alters the spatial distribution and transducer coupling selectivity of the ghrelin receptor.

Authors: Balfe EM Torbey A Stepniewski TM et al.

Source: Molecular pharmacology [Mol Pharmacol] 2026 Apr; Vol. 108 (4), pp. 100119. Date of Electronic Publication: 2026 Mar 13.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

Large scale investigation of GPCR molecular dynamics data uncovers allosteric sites and lateral gateways.

Authors: Aranda-García D Stepniewski TM Torrens-Fontanals M et al.

Source: Nature communications [Nat Commun] 2025 Feb 27; Vol. 16 (1), pp. 2020. Date of Electronic Publication: 2025 Feb 27.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Type-1 Cannabinoid Receptor Promiscuous Coupling: Computational Insights into Receptor-G Protein Interaction Dynamics.

Authors: Berghella A Stepniewski TM Sabatucci A et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2025 Dec 10; Vol. 26 (24). Date of Electronic Publication: 2025 Dec 10.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Phosphorylation patterns in the AT1R C-terminal tail specify distinct downstream signaling pathways.

Authors: Gareri C Pfeiffer CT Jiang X et al.

Source: Science signaling [Sci Signal] 2024 Aug 13; Vol. 17 (849), pp. eadk5736. Date of Electronic Publication: 2024 Aug 13.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

Distinctive patterns of G protein coupling induced by the structurally similar 5-HT2A receptor ligands ketanserin and altanserin in human prefrontal cortex.

Authors: Miranda-Azpiazu P Muguruza C Stepniewski TM et al.

Source: Molecular pharmacology [Mol Pharmacol] 2025 Nov; Vol. 107 (11), pp. 100075. Date of Electronic Publication: 2025 Sep 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-0111 (Electronic) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

Molecular insights into atypical modes of β-arrestin interaction with seven transmembrane receptors.

Authors: Maharana J Sano FK Sarma P et al.

Source: Science (New York, N.Y.) [Science] 2024 Jan 05; Vol. 383 (6678), pp. 101-108. Date of Electronic Publication: 2024 Jan 04.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

A Structural Mechanism for Noncanonical GPCR Signal Transduction in the Hedgehog Pathway.

Authors: Steiner WP Iverson N Liu G et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 May 27. Date of Electronic Publication: 2025 May 27.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Migration mediated by the oxysterol receptor GPR183 depends on arrestin coupling but not receptor internalization.

Authors: Kjær VMS Daugvilaite V Stepniewski TM et al.

Source: Science signaling [Sci Signal] 2023 Apr 04; Vol. 16 (779), pp. eabl4283. Date of Electronic Publication: 2023 Apr 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE

Allosteric modulation of GPCR-induced β-arrestin trafficking and signaling by a synthetic intrabody.

Authors: Baidya M Chaturvedi M Dwivedi-Agnihotri H et al.

Source: Nature communications [Nat Commun] 2022 Aug 08; Vol. 13 (1), pp. 4634. Date of Electronic Publication: 2022 Aug 08.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

G protein-specific mechanisms in the serotonin 5-HT2A receptor regulate psychosis-related effects and memory deficits.

Authors: Kossatz E Diez-Alarcia R Gaitonde SA et al.

Source: Nature communications [Nat Commun] 2024 May 29; Vol. 15 (1), pp. 4307. Date of Electronic Publication: 2024 May 29.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen.

Authors: Giubilaro J Schuetz DA Stepniewski TM et al.

Source: Nature communications [Nat Commun] 2021 Aug 03; Vol. 12 (1), pp. 4688. Date of Electronic Publication: 2021 Aug 03.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Key phosphorylation sites in GPCRs orchestrate the contribution of β-Arrestin 1 in ERK1/2 activation.

Authors: Baidya M Kumari P Dwivedi-Agnihotri H et al.

Source: EMBO reports [EMBO Rep] 2020 Sep 03; Vol. 21 (9), pp. e49886. Date of Electronic Publication: 2020 Jul 26.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 100963049 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-3178 (Electronic) Linking ISSN: 1469221X NLM ISO Abbreviation: EMBO Rep Subsets: MEDLINE

A highly conserved δ-opioid receptor region determines RGS4 interaction.

Authors: Karoussiotis C Marti-Solano M Stepniewski TM et al.

Source: The FEBS journal [FEBS J] 2020 Feb; Vol. 287 (4), pp. 736-748. Date of Electronic Publication: 2019 Sep 09.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Published by Blackwell Pub. on behalf of the Federation of European Biochemical Societies Country of Publication: England NLM ID: 101229646 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1742-4658 (Electronic) Linking ISSN: 1742464X NLM ISO Abbreviation: FEBS J Subsets: MEDLINE

Plasma membrane preassociation drives β-arrestin coupling to receptors and activation.

Authors: Grimes J Koszegi Z Lanoiselée Y et al.

Source: Cell [Cell] 2023 May 11; Vol. 186 (10), pp. 2238-2255.e20. Date of Electronic Publication: 2023 May 04.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 0413066 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4172 (Electronic) Linking ISSN: 00928674 NLM ISO Abbreviation: Cell Subsets: MEDLINE