Search Results - "Struthers RS"

Gonadotropin-Releasing Hormone Targeting for Gonadotroph Ablation: An Approach to Non-surgical Sterilization.

Authors: Struthers, RS¹

Source: Reproduction in Domestic Animals. Aug2012 Supplement, Vol. 47, p233-238. 6p. 1 Diagram.

Oral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants.

Authors: Luo R Madan A Ferrara-Cook CT et al.

Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2025 Jul; Vol. 91 (7), pp. 2070-2079. Date of Electronic Publication: 2025 Mar 05.

Publication Type: Journal Article; Clinical Trial, Phase I

Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE

Rapid and Sustained Response of Biochemically Uncontrolled Acromegaly to Once-daily Oral Paltusotine Treatment.

Authors: Biller BMK Casagrande A Elenkova A et al.

Source: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2026 Mar 17; Vol. 111 (4), pp. e1050-e1063.

Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE

Acromegaly Disease Control Maintained After Switching From Injected Somatostatin Receptor Ligands to Oral Paltusotine.

Authors: Gadelha MR Casagrande A Strasburger CJ et al.

Source: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2024 Dec 18; Vol. 110 (1), pp. 228-237.

Publication Type: Journal Article; Randomized Controlled Trial; Clinical Trial, Phase III; Multicenter Study; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE

ACROBAT Edge: Safety and Efficacy of Switching Injected SRLs to Oral Paltusotine in Patients With Acromegaly.

Authors: Gadelha MR Gordon MB Doknic M et al.

Source: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2023 Apr 13; Vol. 108 (5), pp. e148-e159.

Publication Type: Clinical Trial; Multicenter Study; Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print Cited Medium: Internet ISSN: 1945-7197 (Electronic) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE

Paltusotine, a novel oral once-daily nonpeptide SST2 receptor agonist, suppresses GH and IGF-1 in healthy volunteers.

Authors: Madan A Markison S Betz SF et al.

Source: Pituitary [Pituitary] 2022 Apr; Vol. 25 (2), pp. 328-339. Date of Electronic Publication: 2022 Jan 09.

Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial

Journal Info: Publisher: Kluwer Academic Publishers Country of Publication: United States NLM ID: 9814578 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7403 (Electronic) Linking ISSN: 1386341X NLM ISO Abbreviation: Pituitary Subsets: MEDLINE

Discovery of CRN04894: A Novel Potent Selective MC2R Antagonist.

Authors: Kim SH Han S Zhao J et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2024 Mar 19; Vol. 15 (4), pp. 478-485. Date of Electronic Publication: 2024 Mar 19 (Print Publication: 2024).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Discovery of Paltusotine (CRN00808), a Potent, Selective, and Orally Bioavailable Non-peptide SST2 Agonist.

Authors: Zhao J Wang S Markison S et al.

Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Dec 10; Vol. 14 (1), pp. 66-74. Date of Electronic Publication: 2022 Dec 10 (Print Publication: 2023).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE

Discovery of substituted 3H-pyrido[2,3-d]pyrimidin-4-ones as potent, biased, and orally bioavailable sst2 agonist.

Authors: Zhao J Chen Z Kusnetzow AK et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2020 Nov 01; Vol. 30 (21), pp. 127496. Date of Electronic Publication: 2020 Aug 14.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Progress towards the development of non-peptide orally-active gonadotropin-releasing hormone (GnRH) antagonists: therapeutic implications.

Authors: Millar RP Zhu YF Chen C et al.

Source: British medical bulletin [Br Med Bull] 2000; Vol. 56 (3), pp. 761-72.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0376542 Publication Model: Print Cited Medium: Print ISSN: 0007-1420 (Print) Linking ISSN: 00071420 NLM ISO Abbreviation: Br Med Bull Subsets: MEDLINE

Suppression of gonadotropins and estradiol in premenopausal women by oral administration of the nonpeptide gonadotropin-releasing hormone antagonist elagolix.

Authors: Struthers RS Nicholls AJ Grundy J et al.

Source: The Journal of clinical endocrinology and metabolism [J Clin Endocrinol Metab] 2009 Feb; Vol. 94 (2), pp. 545-51. Date of Electronic Publication: 2008 Nov 25.

Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375362 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0021-972X (Print) Linking ISSN: 0021972X NLM ISO Abbreviation: J Clin Endocrinol Metab Subsets: MEDLINE

Discovery of sodium R-(+)-4-{2-[5-(2-fluoro-3-methoxyphenyl)-3-(2-fluoro-6-[trifluoromethyl]benzyl)-4-methyl-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-1-phenylethylamino}butyrate (elagolix), a potent and orally available nonpeptide antagonist of the human gonadotropin-releasing hormone receptor.

Authors: Chen C Wu D Guo Z et al.

Source: Journal of medicinal chemistry [J Med Chem] 2008 Dec 11; Vol. 51 (23), pp. 7478-85.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Zwitterionic uracil derivatives as potent GnRH receptor antagonists with improved pharmaceutical properties.

Authors: Regan CF Guo Z Chen Y et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Aug 15; Vol. 18 (16), pp. 4503-7. Date of Electronic Publication: 2008 Jul 17.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Non-peptide gonadotropin-releasing hormone receptor antagonists.

Authors: Betz SF Zhu YF Chen C et al.

Source: Journal of medicinal chemistry [J Med Chem] 2008 Jun 26; Vol. 51 (12), pp. 3331-48.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Print ISSN: 0022-2623 (Print) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Potent and orally bioavailable zwitterion GnRH antagonists with low CYP3A4 inhibitory activity.

Authors: Chen C Chen Y Pontillo J et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Jun 01; Vol. 18 (11), pp. 3301-5. Date of Electronic Publication: 2008 Apr 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

5-Aryluracils as potent GnRH antagonists-Characterization of atropisomers.

Authors: Zhao L Guo Z Chen Y et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2008 Jun 01; Vol. 18 (11), pp. 3344-9. Date of Electronic Publication: 2008 Apr 15.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Trapping of a nonpeptide ligand by the extracellular domains of the gonadotropin-releasing hormone receptor results in insurmountable antagonism.

Authors: Kohout TA Xie Q Reijmers S et al.

Source: Molecular pharmacology [Mol Pharmacol] 2007 Aug; Vol. 72 (2), pp. 238-47. Date of Electronic Publication: 2007 Apr 04.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 0035623 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0026-895X (Print) Linking ISSN: 0026895X NLM ISO Abbreviation: Mol Pharmacol Subsets: MEDLINE

Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists.

Authors: Chen M Guo Z Lanier MC et al.

Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2007 Jul 15; Vol. 17 (14), pp. 3845-50. Date of Electronic Publication: 2007 May 10.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0960-894X (Print) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE

Pharmacological characterization of a novel nonpeptide antagonist of the human gonadotropin-releasing hormone receptor, NBI-42902.

Authors: Struthers RS Xie Q Sullivan SK et al.

Source: Endocrinology [Endocrinology] 2007 Feb; Vol. 148 (2), pp. 857-67. Date of Electronic Publication: 2006 Nov 09.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0375040 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0013-7227 (Print) Linking ISSN: 00137227 NLM ISO Abbreviation: Endocrinology Subsets: MEDLINE

Allosteric and orthosteric binding modes of two nonpeptide human gonadotropin-releasing hormone receptor antagonists.

Authors: Sullivan SK Brown MS Gao Y et al.

Source: Biochemistry [Biochemistry] 2006 Dec 26; Vol. 45 (51), pp. 15327-37. Date of Electronic Publication: 2006 Dec 01.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE