Search Results - "Symons JA"

Effect of nitrous oxide anesthesia on plasma homocysteine and endothelial function.

Authors: Myles PS Chan MTV Kaye DM et al.

Source: Anesthesiology. 2008 Oct, Vol. 109 Issue 4, p657-663. 7p.

Structural basis for pan-coronavirus inhibition of 3CL protease.

Authors: Reddem ER Forouhar F Liu C et al.

Source: Structure (London, England : 1993) [Structure] 2026 Apr 02; Vol. 34 (4), pp. 562-571.e8. Date of Electronic Publication: 2026 Feb 05.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101087697 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-4186 (Electronic) Linking ISSN: 09692126 NLM ISO Abbreviation: Structure Subsets: MEDLINE

Perioperative Medicine in Australia and New Zealand.

Authors: Cokis CJ Van Acker JD Symons JA et al.

Source: Anesthesia and analgesia [Anesth Analg] 2026 Mar 01; Vol. 142 (3), pp. e52-e53. Date of Electronic Publication: 2025 Dec 30.

Publication Type: Journal Article

Journal Info: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 1310650 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1526-7598 (Electronic) Linking ISSN: 00032999 NLM ISO Abbreviation: Anesth Analg Subsets: MEDLINE; In Process

Discovery and Preclinical Profile of ALG-097558, a Pan-Coronavirus 3CLpro Inhibitor.

Authors: Bardiot D McGowan DC Gupta K et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Jul 10; Vol. 68 (13), pp. 13436-13454. Date of Electronic Publication: 2025 Jun 30.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Lumicitabine, an orally administered nucleoside analog, in infants hospitalized with respiratory syncytial virus (RSV) infection: Safety, efficacy, and pharmacokinetic results.

Authors: Oey A McClure M Symons JA et al.

Corporate Authors: Oey A McClure M Symons JA et al.

Source: PloS one [PLoS One] 2023 Jul 19; Vol. 18 (7), pp. e0288271. Date of Electronic Publication: 2023 Jul 19 (Print Publication: 2023).

Publication Type: Clinical Trial, Phase I; Clinical Trial, Phase II; Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075.

Authors: Vendeville S Amblard F Bassit L et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Dec 12; Vol. 67 (23), pp. 21126-21142. Date of Electronic Publication: 2024 Nov 22.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Discovery and Preclinical Profile of ALG-055009, a Potent and Selective Thyroid Hormone Receptor Beta (THR-β) Agonist for the Treatment of MASH.

Authors: Vandyck K McGowan DC Luong XG et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Sep 12; Vol. 67 (17), pp. 14840-14851. Date of Electronic Publication: 2024 Sep 02.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.

Authors: Debing Y Vanrusselt H Degrauwe L et al.

Source: Antiviral research [Antiviral Res] 2024 Apr; Vol. 224, pp. 105835. Date of Electronic Publication: 2024 Feb 23.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE

Regulation of gene transcription by thyroid hormone receptor β agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).

Authors: Luong XG Stevens SK Jekle A et al.

Source: PloS one [PLoS One] 2020 Dec 11; Vol. 15 (12), pp. e0240338. Date of Electronic Publication: 2020 Dec 11 (Print Publication: 2020).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.

Authors: Jekle A Thatikonda SK Jaisinghani R et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2023 Nov 13; Vol. 24 (22). Date of Electronic Publication: 2023 Nov 13.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.

Authors: Vanrusselt H Kum DB Taverniti V et al.

Source: Journal of virology [J Virol] 2023 Oct 31; Vol. 97 (10), pp. e0072223. Date of Electronic Publication: 2023 Sep 27.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Society For Microbiology Country of Publication: United States NLM ID: 0113724 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1098-5514 (Electronic) Linking ISSN: 0022538X NLM ISO Abbreviation: J Virol Subsets: MEDLINE

Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.

Authors: Kum DB Vanrusselt H Acosta Sanchez A et al.

Source: Hepatology (Baltimore, Md.) [Hepatology] 2023 Oct 01; Vol. 78 (4), pp. 1252-1265. Date of Electronic Publication: 2023 Apr 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 8302946 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-3350 (Electronic) Linking ISSN: 02709139 NLM ISO Abbreviation: Hepatology Subsets: MEDLINE

The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.

Authors: Jochmans D Liu C Donckers K et al.

Source: MBio [mBio] 2023 Feb 28; Vol. 14 (1), pp. e0281522. Date of Electronic Publication: 2023 Jan 10.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Microbiology Country of Publication: United States NLM ID: 101519231 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2150-7511 (Electronic) NLM ISO Abbreviation: mBio Subsets: MEDLINE

Respiratory syncytial virus-A dynamics and the effects of lumicitabine, a nucleoside viral replication inhibitor, in experimentally infected humans.

Authors: Patel K Kirkpatrick CM Nieforth KA et al.

Source: The Journal of antimicrobial chemotherapy [J Antimicrob Chemother] 2019 Feb 01; Vol. 74 (2), pp. 442-452.

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 7513617 Publication Model: Print Cited Medium: Internet ISSN: 1460-2091 (Electronic) Linking ISSN: 03057453 NLM ISO Abbreviation: J Antimicrob Chemother Subsets: MEDLINE

Antiviral Activity, Safety, and Pharmacokinetics of AL-794, a Novel Oral Influenza Endonuclease Inhibitor: Results of an Influenza Human Challenge Study.

Authors: Yogaratnam J Rito J Kakuda TN et al.

Source: The Journal of infectious diseases [J Infect Dis] 2019 Jan 07; Vol. 219 (2), pp. 177-185.

Publication Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: United States NLM ID: 0413675 Publication Model: Print Cited Medium: Internet ISSN: 1537-6613 (Electronic) Linking ISSN: 00221899 NLM ISO Abbreviation: J Infect Dis Subsets: MEDLINE

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase.

Authors: Jordan PC Liu C Raynaud P et al.

Source: PLoS pathogens [PLoS Pathog] 2018 Feb 09; Vol. 14 (2), pp. e1006889. Date of Electronic Publication: 2018 Feb 09 (Print Publication: 2018).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101238921 Publication Model: eCollection Cited Medium: Internet ISSN: 1553-7374 (Electronic) Linking ISSN: 15537366 NLM ISO Abbreviation: PLoS Pathog Subsets: MEDLINE

Mechanism of action of hepatitis B virus S antigen transport-inhibiting oligonucleotide polymer, STOPS, molecules.

Authors: Kao CC Nie Y Ren S et al.

Source: Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2021 Dec 11; Vol. 27, pp. 335-348. Date of Electronic Publication: 2021 Dec 11 (Print Publication: 2022).

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 101581621 Publication Model: eCollection Cited Medium: Print ISSN: 2162-2531 (Print) Linking ISSN: 21622531 NLM ISO Abbreviation: Mol Ther Nucleic Acids Subsets: PubMed not MEDLINE

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase.

Authors: Deval J Fung A Stevens SK et al.

Source: PloS one [PLoS One] 2016 May 10; Vol. 11 (5), pp. e0154097. Date of Electronic Publication: 2016 May 10 (Print Publication: 2016).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.

Authors: Vandyck K Abdelnabi R Gupta K et al.

Source: Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2021 May 28; Vol. 555, pp. 134-139. Date of Electronic Publication: 2021 Mar 26.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2104 (Electronic) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE

Dual inhibition of SARS-CoV-2 and human rhinovirus with protease inhibitors in clinical development.

Authors: Liu C Boland S Scholle MD et al.

Source: Antiviral research [Antiviral Res] 2021 Mar; Vol. 187, pp. 105020. Date of Electronic Publication: 2021 Jan 27.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 8109699 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-9096 (Electronic) Linking ISSN: 01663542 NLM ISO Abbreviation: Antiviral Res Subsets: MEDLINE