Search Results - "Taskar, Kunal"

Physiologically‐Based Pharmacokinetic Modeling to Support Pediatric Clinical Development: An IQ Working Group Perspective on the Current Status and Challenges.

Authors: Yates, James W. T. Zientek, Michael Taskar, Kunal S. et al.

Source: CPT: Pharmacometrics & Systems Pharmacology. Jan2026, Vol. 15 Issue 1, p1-19. 19p.

No dose adjustment of metformin or substrates of organic cation transporters (OCT)1 and OCT2 and multidrug and toxin extrusion protein (MATE)1/2K with fostemsavir coadministration based on modeling approaches.

Authors: Nguyen, Dung Miao, Xiusheng Taskar, Kunal et al.

Source: Pharmacology Research & Perspectives. Aug2024, Vol. 12 Issue 4, p1-10. 10p.

Physiologically‐based pharmacokinetic modeling of prominent oral contraceptive agents and applications in drug–drug interactions.

Authors: Lewis, Gareth J. Ahire, Deepak Taskar, Kunal S.

Source: CPT: Pharmacometrics & Systems Pharmacology. Apr2024, Vol. 13 Issue 4, p563-575. 13p.

Physiologically‐Based Pharmacokinetic Modeling of the PARP Inhibitor Niraparib.

Authors: Lewis, Gareth J. Jewell, Roxanne C. Krishnatry, Anu Shilpa et al.

Source: CPT: Pharmacometrics & Systems Pharmacology. Jan2026, Vol. 15 Issue 1, p1-12. 12p.

Importance of Hepatic Transporters in Clinical Disposition of Drugs and Their Metabolites.

Authors: Patel, Mitesh Taskar, Kunal S. Zamek‐Gliszczynski, Maciej J.

Source: Journal of Clinical Pharmacology. Jul2016 Supplement, Vol. 56, pS23-S39. 17p.

Lapatinib Distribution in HER2 Overexpressing Experimental Brain Metastases of Breast Cancer.

Authors: Taskar, Kunal Rudraraju, Vinay Mittapalli, Rajendar et al.

Source: Pharmaceutical Research. Mar2012, Vol. 29 Issue 3, p770-781. 12p. 2 Color Photographs, 1 Diagram, 1 Chart, 5 Graphs.

Matrix Approach Assessment of Cabotegravir Drug–Drug Interactions with OAT1/OAT3 Substrates and UGT1A1/UGT1A9 Inhibitors Using Physiologically-Based Pharmacokinetic Modeling.

Authors: Tracey, Helen Bate, Simon T. Ford, Susan et al.

Source: Pharmaceutics. Apr2025, Vol. 17 Issue 4, p531. 20p.

Development of a physiologically based pharmacokinetic model of fostemsavir and its pivotal application to support dosing in pregnancy.

Authors: Salem, Farzaneh Nguyen, Dung Bush, Mark et al.

Source: CPT: Pharmacometrics & Systems Pharmacology. Nov2024, Vol. 13 Issue 11, p1881-1892. 12p.

Drug transporters in drug disposition – the year 2022 in review.

Authors: Chothe, Paresh P. Mitra, Pallabi Nakakariya, Masanori et al.

Source: Drug Metabolism Reviews. Nov2023, Vol. 55 Issue 4, p343-370. 28p.

Physiologically based pharmacokinetic modeling for development and applications of a virtual celiac disease population using felodipine as a model drug.

Authors: Salem, Farzaneh Nimavardi, Ali Mudunuru, Jennypher et al.

Source: CPT: Pharmacometrics & Systems Pharmacology. Jun2023, Vol. 12 Issue 6, p808-820. 13p.

When special populations intersect with drug–drug interactions: Application of physiologically‐based pharmacokinetic modeling in pregnant populations.

Authors: Sychterz, Caroline Galetin, Aleksandra Taskar, Kunal S.

Source: Biopharmaceutics & Drug Disposition. Apr2021, Vol. 42 Issue 4, p160-177. 18p.

Robust physiologically based pharmacokinetic model of rifampicin for predicting drug–drug interactions via P‐glycoprotein induction and inhibition in the intestine, liver, and kidney.

Authors: Asaumi, Ryuta Nunoya, Ken‐ichi Yamaura, Yoshiyuki et al.

Source: CPT: Pharmacometrics & Systems Pharmacology. Jul2022, Vol. 11 Issue 7, p919-933. 15p.

Physiologically‐based pharmacokinetic model‐based translation of OATP1B‐mediated drug–drug interactions from coproporphyrin I to probe drugs.

Authors: Mochizuki, Tatsuki Aoki, Yasunori Yoshikado, Takashi et al.

Source: CTS: Clinical & Translational Science. Jun2022, Vol. 15 Issue 6, p1519-1531. 13p.

Anticancer drug delivery to brain metastases of breast cancer

Authors: Taskar, Kunal Shekhar

Committee Members: Mehvar, Reza; Abbruscato, Thomas J.; Weidanz, Jon; Gunaje, Jayarama; Smith, Quentin R.

URL: http://hdl.handle.net/2346/66922

Vinorelbine Delivery and Efficacy in the MDA-MB-231BR Preclinical Model of Brain Metastases of Breast Cancer.

Authors: Samala, Ramakrishna Thorsheim, Helen Goda, Satyanarayana et al.

Source: Pharmaceutical Research. Dec2016, Vol. 33 Issue 12, p2904-2919. 16p.

Drug-drug interaction assessments of clinical transporter inhibition: Learnings from the Transporter Working Group of the International Consortium for Innovation and Quality in Pharmaceutical Development.

Authors: Sane RS Mitra P Lai Y et al.

Source: Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 2026 Apr; Vol. 54 (4), pp. 100255. Date of Electronic Publication: 2026 Feb 24.

Publication Type: Journal Article

Journal Info: Publisher: American Society for Pharmacology and Experimental Therapeutics, etc.] Country of Publication: Netherlands NLM ID: 9421550 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1521-009X (Electronic) Linking ISSN: 00909556 NLM ISO Abbreviation: Drug Metab Dispos Subsets: MEDLINE

PBPK Modelling of PROTACs: Learnings from ARV-110 as a Case Example.

Authors: Salem F Tabatabaeian Nimavardi A Srivastava A et al.

Source: The AAPS journal [AAPS J] 2026 Mar 27; Vol. 28 (3). Date of Electronic Publication: 2026 Mar 27.

Publication Type: Journal Article

Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE

PBPK Modelling of Antisense Oligonucleotide Therapeutics: Application for Predicting Plasma and Tissue Pharmacokinetics of Bepirovirsen.

Authors: Salem F Stader F Youssef AS et al.

Source: The AAPS journal [AAPS J] 2026 Mar 13; Vol. 28 (2). Date of Electronic Publication: 2026 Mar 13.

Publication Type: Journal Article

Journal Info: Publisher: American Association of Pharmaceutical Scientists Country of Publication: United States NLM ID: 101223209 Publication Model: Electronic Cited Medium: Internet ISSN: 1550-7416 (Electronic) Linking ISSN: 15507416 NLM ISO Abbreviation: AAPS J Subsets: MEDLINE

Strategy for Identifying Rational Sensitivity Analysis Using PBPK Modeling for Precipitant Drug-Drug Interaction Predictions.

Authors: Taskar KS Sharma P Rowland Yeo K

Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2026 Feb; Vol. 119 (2), pp. 314-317. Date of Electronic Publication: 2025 Nov 13.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE

Building Confidence in Physiologically Based Pharmacokinetic Modeling of CYP3A Induction Mediated by Rifampin: An Industry Perspective.

Authors: Reddy MB Cabalu TD de Zwart L et al.

Source: Clinical pharmacology and therapeutics [Clin Pharmacol Ther] 2025 Feb; Vol. 117 (2), pp. 403-420. Date of Electronic Publication: 2024 Oct 18.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 0372741 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1532-6535 (Electronic) Linking ISSN: 00099236 NLM ISO Abbreviation: Clin Pharmacol Ther Subsets: MEDLINE