Search Results - "Theile CS"

Acyclic serinol nucleic acid modification of siRNAs overcomes seed region mediated off-target effects while maintaining potency.

Authors: Chickering T Harp JM Jiang Y et al.

Source: Nucleic acids research [Nucleic Acids Res] 2026 Apr 13; Vol. 54 (7).

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Evaluating the oral delivery of GalNAc-conjugated siRNAs in rodents and non-human primates.

Authors: Yu M Qin J Liu X et al.

Source: Nucleic acids research [Nucleic Acids Res] 2024 Jun 10; Vol. 52 (10), pp. 5423-5437.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Expanding the binding space of argonaute-2: incorporation of either E or Z isomers of 6'-vinylphosphonate at the 5' end of the antisense strand improves RNAi activity.

Authors: Datta D Kundu J Miller P et al.

Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 Apr 29; Vol. 61 (36), pp. 6659-6662. Date of Electronic Publication: 2025 Apr 29.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

Single-Stranded Hairpin Loop RNAs (loopmeRNAs) Potently Induce Gene Silencing through the RNA Interference Pathway.

Authors: Aluri KC Datta D Waldron S et al.

Source: Journal of the American Chemical Society [J Am Chem Soc] 2024 Oct 07. Date of Electronic Publication: 2024 Oct 07.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

Investigating the pharmacodynamic durability of GalNAc-siRNA conjugates.

Authors: Brown CR Gupta S Qin J et al.

Source: Nucleic acids research [Nucleic Acids Res] 2020 Dec 02; Vol. 48 (21), pp. 11827-11844.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

Shorter Is Better: The α-(l)-Threofuranosyl Nucleic Acid Modification Improves Stability, Potency, Safety, and Ago2 Binding and Mitigates Off-Target Effects of Small Interfering RNAs.

Authors: Matsuda S Bala S Liao JY et al.

Source: Journal of the American Chemical Society [J Am Chem Soc] 2023 Sep 13; Vol. 145 (36), pp. 19691-19706. Date of Electronic Publication: 2023 Aug 28.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 7503056 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-5126 (Electronic) Linking ISSN: 00027863 NLM ISO Abbreviation: J Am Chem Soc Subsets: MEDLINE

Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.

Authors: Datta D Theile CS Wassarman K et al.

Source: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2023 May 23; Vol. 59 (42), pp. 6347-6350. Date of Electronic Publication: 2023 May 23.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 9610838 Publication Model: Electronic Cited Medium: Internet ISSN: 1364-548X (Electronic) Linking ISSN: 13597345 NLM ISO Abbreviation: Chem Commun (Camb) Subsets: MEDLINE

Expanding RNAi therapeutics to extrahepatic tissues with lipophilic conjugates.

Authors: Brown KM Nair JK Janas MM et al.

Source: Nature biotechnology [Nat Biotechnol] 2022 Oct; Vol. 40 (10), pp. 1500-1508. Date of Electronic Publication: 2022 Jun 02.

Publication Type: Journal Article

Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Authors: Elkayam E Parmar R Brown CR et al.

Source: Nucleic acids research [Nucleic Acids Res] 2017 May 05; Vol. 45 (8), pp. 5008.

Publication Type: Journal Article; Published Erratum

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: PubMed not MEDLINE

siRNA carrying an (E)-vinylphosphonate moiety at the 5΄ end of the guide strand augments gene silencing by enhanced binding to human Argonaute-2.

Authors: Elkayam E Parmar R Brown CR et al.

Source: Nucleic acids research [Nucleic Acids Res] 2017 Apr 07; Vol. 45 (6), pp. 3528-3536.

Publication Type: Journal Article

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

Authors: Parmar R Willoughby JL Liu J et al.

Source: Chembiochem : a European journal of chemical biology [Chembiochem] 2016 Jun 02; Vol. 17 (11), pp. 985-9. Date of Electronic Publication: 2016 Apr 28.

Publication Type: Journal Article

Journal Info: Publisher: Wiley-VCH Verlag Country of Publication: Germany NLM ID: 100937360 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1439-7633 (Electronic) Linking ISSN: 14394227 NLM ISO Abbreviation: Chembiochem Subsets: MEDLINE

Centyrin ligands for extrahepatic delivery of siRNA.

Authors: Klein D Goldberg S Theile CS et al.

Source: Molecular therapy : the journal of the American Society of Gene Therapy [Mol Ther] 2021 Jun 02; Vol. 29 (6), pp. 2053-2066. Date of Electronic Publication: 2021 Feb 15.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 100890581 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1525-0024 (Electronic) Linking ISSN: 15250016 NLM ISO Abbreviation: Mol Ther Subsets: MEDLINE

Turnip yellow mosaic virus protease binds ubiquitin suboptimally to fine-tune its deubiquitinase activity.

Authors: Fieulaine S Witte MD Theile CS et al.

Source: The Journal of biological chemistry [J Biol Chem] 2020 Oct 02; Vol. 295 (40), pp. 13769-13783. Date of Electronic Publication: 2020 Jul 30.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Site-specific protein modification using immobilized sortase in batch and continuous-flow systems.

Authors: Witte MD Wu T Guimaraes CP et al.

Source: Nature protocols [Nat Protoc] 2015 Mar; Vol. 10 (3), pp. 508-16. Date of Electronic Publication: 2015 Feb 26.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE

Site-specific chemoenzymatic labeling of aerolysin enables the identification of new aerolysin receptors.

Authors: Wuethrich I Peeters JG Blom AE et al.

Source: PloS one [PLoS One] 2014 Oct 02; Vol. 9 (10), pp. e109883. Date of Electronic Publication: 2014 Oct 02 (Print Publication: 2014).

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

A catalytic independent function of the deubiquitinating enzyme USP14 regulates hippocampal synaptic short-term plasticity and vesicle number.

Authors: Walters BJ Hallengren JJ Theile CS et al.

Source: The Journal of physiology [J Physiol] 2014 Feb 15; Vol. 592 (4), pp. 571-86. Date of Electronic Publication: 2013 Nov 11.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cambridge Univ. Press Country of Publication: England NLM ID: 0266262 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1469-7793 (Electronic) Linking ISSN: 00223751 NLM ISO Abbreviation: J Physiol Subsets: MEDLINE

Production of unnaturally linked chimeric proteins using a combination of sortase-catalyzed transpeptidation and click chemistry.

Authors: Witte MD Theile CS Wu T et al.

Source: Nature protocols [Nat Protoc] 2013 Sep; Vol. 8 (9), pp. 1808-19. Date of Electronic Publication: 2013 Aug 29.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE

Site-specific C-terminal and internal loop labeling of proteins using sortase-mediated reactions.

Authors: Guimaraes CP Witte MD Theile CS et al.

Source: Nature protocols [Nat Protoc] 2013 Sep; Vol. 8 (9), pp. 1787-99. Date of Electronic Publication: 2013 Aug 29.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE

Site-specific N-terminal labeling of proteins using sortase-mediated reactions.

Authors: Theile CS Witte MD Blom AE et al.

Source: Nature protocols [Nat Protoc] 2013 Sep; Vol. 8 (9), pp. 1800-7. Date of Electronic Publication: 2013 Aug 29.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101284307 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1750-2799 (Electronic) Linking ISSN: 17502799 NLM ISO Abbreviation: Nat Protoc Subsets: MEDLINE

Synthesis and properties of DNA containing cyclonucleosides.

Authors: Yueh H Yu H Theile CS et al.

Source: Nucleosides, nucleotides & nucleic acids [Nucleosides Nucleotides Nucleic Acids] 2012; Vol. 31 (9), pp. 661-79.

Publication Type: Journal Article

Journal Info: Publisher: Taylor & Francis Country of Publication: United States NLM ID: 100892832 Publication Model: Print Cited Medium: Internet ISSN: 1532-2335 (Electronic) Linking ISSN: 15257770 NLM ISO Abbreviation: Nucleosides Nucleotides Nucleic Acids Subsets: MEDLINE