Search Results - "Timms RT"

LRRC58 defines an E3 ubiquitin ligase complex sensitive to cysteine abundance.

Authors: Ramage DE Wieske LHE Crowe C et al.

Source: Molecular cell [Mol Cell] 2026 Jul 16; Vol. 86 (14), pp. 2828-2842.e12. Date of Electronic Publication: 2026 Jun 19.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Proteome-wide C-degron activity profiling connects conditional regulation of the CTLH E3 ligase complex to ribosome biogenesis.

Authors: Grant DW Tan S Ramage DE et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2026 Jan 14. Date of Electronic Publication: 2026 Jan 14.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Degrons: defining the rules of protein degradation.

Authors: Zhang Z Mena EL Timms RT et al.

Source: Nature reviews. Molecular cell biology [Nat Rev Mol Cell Biol] 2025 Nov; Vol. 26 (11), pp. 868-883. Date of Electronic Publication: 2025 Jul 14.

Publication Type: Journal Article; Review

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 100962782 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-0080 (Electronic) Linking ISSN: 14710072 NLM ISO Abbreviation: Nat Rev Mol Cell Biol Subsets: MEDLINE

Mechanism of Ψ-Pro/C-degron recognition by the CRL2^FEM1B ubiquitin ligase.

Authors: Chen X Raiff A Li S et al.

Source: Nature communications [Nat Commun] 2024 Apr 26; Vol. 15 (1), pp. 3558. Date of Electronic Publication: 2024 Apr 26.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

CRAMP1 drives linker histone expression to enable Polycomb repression.

Authors: Matthews RE Danac JMC Naden EL et al.

Source: Molecular cell [Mol Cell] 2025 Jul 03; Vol. 85 (13), pp. 2503-2516.e8. Date of Electronic Publication: 2025 Jun 13.

Publication Type: Journal Article

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Loss-of-function mutations in the dystonia gene THAP1 impair proteasome function by inhibiting PSMB5 expression.

Authors: Ramage DE Grant DW Timms RT

Source: Nature communications [Nat Commun] 2025 Feb 10; Vol. 16 (1), pp. 1511. Date of Electronic Publication: 2025 Feb 10.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses.

Authors: Shrock EL Timms RT Kula T et al.

Source: Science (New York, N.Y.) [Science] 2023 Apr 07; Vol. 380 (6640), pp. eadc9498. Date of Electronic Publication: 2023 Apr 07.

Publication Type: Journal Article

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Competition between two HUSH complexes orchestrates the immune response to retroelement invasion.

Authors: Danac JMC Matthews RE Gungi A et al.

Source: Molecular cell [Mol Cell] 2024 Aug 08; Vol. 84 (15), pp. 2870-2881.e5. Date of Electronic Publication: 2024 Jul 15.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

Dipeptidyl peptidases and E3 ligases of N-degron pathways cooperate to regulate protein stability.

Authors: Shimshon A Dahan K Israel-Gueta M et al.

Source: The Journal of cell biology [J Cell Biol] 2024 Aug 05; Vol. 223 (8). Date of Electronic Publication: 2024 Jun 14.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Rockefeller University Press Country of Publication: United States NLM ID: 0375356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1540-8140 (Electronic) Linking ISSN: 00219525 NLM ISO Abbreviation: J Cell Biol Subsets: MEDLINE

Author Correction: Defining E3 ligase-substrate relationships through multiplex CRISPR screening.

Authors: Timms RT Mena EL Leng Y et al.

Source: Nature cell biology [Nat Cell Biol] 2024 Feb; Vol. 26 (2), pp. 305.

Publication Type: Published Erratum

Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE; PubMed not MEDLINE

Viral epitope profiling of COVID-19 patients reveals cross-reactivity and correlates of severity.

Authors: Shrock E Fujimura E Kula T et al.

Corporate Authors: Shrock E Fujimura E Kula T et al.

Source: Science (New York, N.Y.) [Science] 2020 Nov 27; Vol. 370 (6520). Date of Electronic Publication: 2020 Sep 29.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE

Periphilin self-association underpins epigenetic silencing by the HUSH complex.

Authors: Prigozhin DM Douse CH Farleigh LE et al.

Source: Nucleic acids research [Nucleic Acids Res] 2020 Oct 09; Vol. 48 (18), pp. 10313-10328.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN: 1362-4962 (Electronic) Linking ISSN: 03051048 NLM ISO Abbreviation: Nucleic Acids Res Subsets: MEDLINE

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.

Authors: Douse CH Tchasovnikarova IA Timms RT et al.

Source: Nature communications [Nat Commun] 2020 Oct 02; Vol. 11 (1), pp. 4940. Date of Electronic Publication: 2020 Oct 02.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Tying up loose ends: the N-degron and C-degron pathways of protein degradation.

Authors: Timms RT Koren I

Source: Biochemical Society transactions [Biochem Soc Trans] 2020 Aug 28; Vol. 48 (4), pp. 1557-1567.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Review

Journal Info: Publisher: Portland Press On The Behalf Of The Biochemical Society Country of Publication: England NLM ID: 7506897 Publication Model: Print Cited Medium: Internet ISSN: 1470-8752 (Electronic) Linking ISSN: 03005127 NLM ISO Abbreviation: Biochem Soc Trans Subsets: MEDLINE

Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.

Authors: Zhang Z Sie B Chang A et al.

Source: Molecular cell [Mol Cell] 2023 Nov 16; Vol. 83 (22), pp. 4191-4192. Date of Electronic Publication: 2023 Nov 16.

Publication Type: Published Erratum

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE; PubMed not MEDLINE

Defining E3 ligase-substrate relationships through multiplex CRISPR screening.

Authors: Timms RT Mena EL Leng Y et al.

Source: Nature cell biology [Nat Cell Biol] 2023 Oct; Vol. 25 (10), pp. 1535-1545. Date of Electronic Publication: 2023 Sep 21.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Macmillan Magazines Ltd Country of Publication: England NLM ID: 100890575 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-4679 (Electronic) Linking ISSN: 14657392 NLM ISO Abbreviation: Nat Cell Biol Subsets: MEDLINE

Elucidation of E3 ubiquitin ligase specificity through proteome-wide internal degron mapping.

Authors: Zhang Z Sie B Chang A et al.

Source: Molecular cell [Mol Cell] 2023 Sep 21; Vol. 83 (18), pp. 3377-3392.e6.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

High-throughput, targeted MHC class I immunopeptidomics using a functional genetics screening platform.

Authors: Bruno PM Timms RT Abdelfattah NS et al.

Source: Nature biotechnology [Nat Biotechnol] 2023 Jul; Vol. 41 (7), pp. 980-992. Date of Electronic Publication: 2023 Jan 02.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Nature America Publishing Country of Publication: United States NLM ID: 9604648 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1696 (Electronic) Linking ISSN: 10870156 NLM ISO Abbreviation: Nat Biotechnol Subsets: MEDLINE

Ubiquitin-independent proteasomal degradation driven by C-degron pathways.

Authors: Makaros Y Raiff A Timms RT et al.

Source: Molecular cell [Mol Cell] 2023 Jun 01; Vol. 83 (11), pp. 1921-1935.e7. Date of Electronic Publication: 2023 May 17.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Cell Press Country of Publication: United States NLM ID: 9802571 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1097-4164 (Electronic) Linking ISSN: 10972765 NLM ISO Abbreviation: Mol Cell Subsets: MEDLINE

A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.

Authors: Timms RT Zhang Z Rhee DY et al.

Source: Science (New York, N.Y.) [Science] 2019 Jul 05; Vol. 365 (6448).

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE