Search Results - "Tyler PC"

Isofagomine Derivatives as TcdB Glucosyltransferase Inhibitors.

Authors: Shaffer KJ Gilaj N Wagner AG et al.

Source: Journal of medicinal chemistry [J Med Chem] 2026 Jul 23; Vol. 69 (14), pp. 16722-16747. Date of Electronic Publication: 2026 Jul 01.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Transition State Analogs of Human DNPH1 Reveal Two Electrophile Migration Mechanisms.

Authors: Wagner AG Lang TBD Ledingham ET et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Feb 13; Vol. 68 (3), pp. 3653-3672. Date of Electronic Publication: 2025 Jan 16.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues.

Authors: Paparella AS Aboulache BL Harijan RK et al.

Source: Nature communications [Nat Commun] 2021 Nov 01; Vol. 12 (1), pp. 6285. Date of Electronic Publication: 2021 Nov 01.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2.

Authors: Shaffer KJ Smith RAA Daines AM et al.

Source: Carbohydrate polymers [Carbohydr Polym] 2024 Jun 01; Vol. 333, pp. 121979. Date of Electronic Publication: 2024 Feb 25.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier Applied Science Publishers Country of Publication: England NLM ID: 8307156 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1344 (Electronic) Linking ISSN: 01448617 NLM ISO Abbreviation: Carbohydr Polym Subsets: MEDLINE

Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality.

Authors: Paparella AS Brew I Hong HA et al.

Source: ACS infectious diseases [ACS Infect Dis] 2024 Mar 08; Vol. 10 (3), pp. 928-937. Date of Electronic Publication: 2024 Feb 09.

Publication Type: Journal Article

Journal Info: Publisher: ACS Publications Country of Publication: United States NLM ID: 101654580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-8227 (Electronic) Linking ISSN: 23738227 NLM ISO Abbreviation: ACS Infect Dis Subsets: MEDLINE

Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition.

Authors: Bedard GT Gilaj N Peregrina K et al.

Source: The Journal of biological chemistry [J Biol Chem] 2024 Jan; Vol. 300 (1), pp. 105492. Date of Electronic Publication: 2023 Nov 23.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Inc. on behalf of American Society for Biochemistry and Molecular Biology Country of Publication: United States NLM ID: 2985121R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1083-351X (Electronic) Linking ISSN: 00219258 NLM ISO Abbreviation: J Biol Chem Subsets: MEDLINE

Enhancing BMP-2-mediated osteogenesis with a synthetic heparan sulfate mimetic.

Authors: Smith RAA Luo X Lu X et al.

Source: Biomaterials advances [Biomater Adv] 2023 Oct 24; Vol. 155, pp. 213671. Date of Electronic Publication: 2023 Oct 24.

Publication Type: Journal Article

Journal Info: Publisher: Elsevier B.V Country of Publication: Netherlands NLM ID: 9918383886206676 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2772-9508 (Electronic) Linking ISSN: 27729508 NLM ISO Abbreviation: Biomater Adv Subsets: MEDLINE

Isofagomine inhibits multiple TcdB variants and protects mice from Clostridioides difficile induced mortality.

Authors: Paparella AS Brew I Hong HA et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2023 Sep 19. Date of Electronic Publication: 2023 Sep 19.

Publication Type: Preprint; Journal Article

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides.

Authors: Miller RL Guimond SE Schwörer R et al.

Source: Nature communications [Nat Commun] 2020 Mar 20; Vol. 11 (1), pp. 1481. Date of Electronic Publication: 2020 Mar 20.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Expedient synthesis of imino-C-nucleoside fleximers featuring a one-pot procedure to prepare aryl triazoles.

Authors: Wong CHA Hubert JG Sparrow KJ et al.

Source: Organic & biomolecular chemistry [Org Biomol Chem] 2023 Aug 02; Vol. 21 (30), pp. 6134-6140. Date of Electronic Publication: 2023 Aug 02.

Publication Type: Journal Article

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Electronic Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE; PubMed not MEDLINE

Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors.

Authors: Glockzin K Meneely KM Hughes R et al.

Source: Biochemistry [Biochemistry] 2023 Jul 18; Vol. 62 (14), pp. 2182-2201. Date of Electronic Publication: 2023 Jul 07.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Residence Times for Femtomolar and Picomolar Inhibitors of MTANs.

Authors: Brown M Tyler PC Schramm VL

Source: Biochemistry [Biochemistry] 2023 Jun 06; Vol. 62 (11), pp. 1776-1785. Date of Electronic Publication: 2023 May 19.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase.

Authors: V T Minnow Y Suthagar K Clinch K et al.

Source: ACS chemical biology [ACS Chem Biol] 2022 Dec 16; Vol. 17 (12), pp. 3407-3419. Date of Electronic Publication: 2022 Nov 22.

Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101282906 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1554-8937 (Electronic) Linking ISSN: 15548929 NLM ISO Abbreviation: ACS Chem Biol Subsets: MEDLINE

The design of protozoan phosphoribosyltransferase inhibitors containing non-charged phosphate mimic residues.

Authors: Gai S Suthagar K Shaffer KJ et al.

Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2022 Nov 15; Vol. 74, pp. 117038. Date of Electronic Publication: 2022 Sep 28.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE

Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine-Guanine Phosphoribosyltransferases.

Authors: Glockzin K Kostomiris D Minnow YVT et al.

Source: Biochemistry [Biochemistry] 2022 Oct 04; Vol. 61 (19), pp. 2088-2105. Date of Electronic Publication: 2022 Sep 15.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1.

Authors: Lamiable-Oulaidi F Harijan RK Shaffer KJ et al.

Source: Journal of medicinal chemistry [J Med Chem] 2022 Apr 14; Vol. 65 (7), pp. 5462-5494. Date of Electronic Publication: 2022 Mar 24.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Immucillins ImmA and ImmH Are Effective and Non-toxic in the Treatment of Experimental Visceral Leishmaniasis.

Authors: Freitas EO Nico D Alves-Silva MV et al.

Source: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2015 Dec 23; Vol. 9 (12), pp. e0004297. Date of Electronic Publication: 2015 Dec 23 (Print Publication: 2015).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101291488 Publication Model: eCollection Cited Medium: Internet ISSN: 1935-2735 (Electronic) Linking ISSN: 19352727 NLM ISO Abbreviation: PLoS Negl Trop Dis Subsets: MEDLINE

Aminofutalosine Deaminase in the Menaquinone Pathway of Helicobacter pylori.

Authors: Feng M Harijan RK Harris LD et al.

Source: Biochemistry [Biochemistry] 2021 Jun 22; Vol. 60 (24), pp. 1933-1946. Date of Electronic Publication: 2021 Jun 02.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 0370623 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4995 (Electronic) Linking ISSN: 00062960 NLM ISO Abbreviation: Biochemistry Subsets: MEDLINE

Immucillins Impair Leishmania (L.) infantum chagasi and Leishmania (L.) amazonensis Multiplication In Vitro.

Authors: Freitas EO Nico D Guan R et al.

Source: PloS one [PLoS One] 2015 Apr 24; Vol. 10 (4), pp. e0124183. Date of Electronic Publication: 2015 Apr 24 (Print Publication: 2015).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Comparison of disaccharide donors for heparan sulfate synthesis: uronic acids vs. their pyranose equivalents.

Authors: Sheppard DJ Cameron SA Tyler PC et al.

Source: Organic & biomolecular chemistry [Org Biomol Chem] 2020 Jul 01; Vol. 18 (25), pp. 4728-4733.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101154995 Publication Model: Print Cited Medium: Internet ISSN: 1477-0539 (Electronic) Linking ISSN: 14770520 NLM ISO Abbreviation: Org Biomol Chem Subsets: MEDLINE; PubMed not MEDLINE