Search Results - "Valant C"

P.1.j.011 Synthesis and pharmacological evaluation of irreversible allosteric ligands for the M1 muscarinic acetylcholine receptor.

Authors: Davie, B.J. Valant, C. Capuano, B. et al.

Source: European Neuropsychopharmacology. Oct2013 Supplement 2, Vol. 23, pS287-S288. 1p.

Optical–feedback cavity–enhanced absorption: a compact spectrometer for real–time measurement of atmospheric methane.

Authors: Romanini, D. Chenevier, M. Kassi, S. et al.

Source: Applied Physics B: Lasers & Optics. Jun2006, Vol. 83 Issue 4, p659-667. 9p. 1 Color Photograph, 6 Graphs.

Low Agonism and Balanced Pathway Modulation Distinguish an M1 Muscarinic Receptor Positive Allosteric Modulator Lacking Cholinergic Adverse Effects.

Authors: Nguyen HTM Khajehali E Pham V et al.

Source: ACS chemical neuroscience [ACS Chem Neurosci] 2026 Jul 15; Vol. 17 (14), pp. 2641-2659. Date of Electronic Publication: 2026 Jun 30.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

Cryo-EM reveals an extrahelical allosteric binding site at the M5 mAChR.

Authors: Burger WAC Mobbs JI Rana B et al.

Source: Nature communications [Nat Commun] 2025 Jul 31; Vol. 16 (1), pp. 7046. Date of Electronic Publication: 2025 Jul 31.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.

Authors: Alexander SPH Davenport AP Kelly E et al.

Source: British journal of pharmacology [Br J Pharmacol] 2025 Dec; Vol. 182 Suppl 1, pp. S24-S151.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders.

Authors: Saito A Alvi S Valant C et al.

Source: British journal of pharmacology [Br J Pharmacol] 2024 Jul; Vol. 181 (14), pp. 2232-2246. Date of Electronic Publication: 2023 Jan 18.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Opportunities and challenges for the development of M1 muscarinic receptor positive allosteric modulators in the treatment for neurocognitive deficits.

Authors: Nguyen HTM van der Westhuizen ET Langmead CJ et al.

Source: British journal of pharmacology [Br J Pharmacol] 2024 Jul; Vol. 181 (14), pp. 2114-2142. Date of Electronic Publication: 2022 Dec 04.

Publication Type: Journal Article; Review

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Importance of receptor expression in the classification of novel ligands at the M2 muscarinic acetylcholine receptor.

Authors: Jiang Y Yeasmin M Gondin AB et al.

Source: British journal of pharmacology [Br J Pharmacol] 2024 Jul; Vol. 181 (14), pp. 2338-2350. Date of Electronic Publication: 2023 Jan 20.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Structure-guided allosteric modulation of the delta opioid receptor.

Authors: Mobbs JI Nguyen MD Deo O et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Oct 17. Date of Electronic Publication: 2025 Oct 17.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

A Structure-Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor.

Authors: Deo O Pham V Alvi S et al.

Source: ACS chemical neuroscience [ACS Chem Neurosci] 2025 Aug 06; Vol. 16 (15), pp. 2958-2977. Date of Electronic Publication: 2025 Jul 18.

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101525337 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1948-7193 (Electronic) Linking ISSN: 19487193 NLM ISO Abbreviation: ACS Chem Neurosci Subsets: MEDLINE

The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

Authors: Alexander SPH Christopoulos A Davenport AP et al.

Source: British journal of pharmacology [Br J Pharmacol] 2023 Oct; Vol. 180 Suppl 2, pp. S23-S144.

Publication Type: Journal Article

Journal Info: Publisher: Wiley Country of Publication: England NLM ID: 7502536 Publication Model: Print Cited Medium: Internet ISSN: 1476-5381 (Electronic) Linking ISSN: 00071188 NLM ISO Abbreviation: Br J Pharmacol Subsets: MEDLINE

Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR.

Authors: Burger WAC Pham V Vuckovic Z et al.

Source: Nature communications [Nat Commun] 2023 Sep 06; Vol. 14 (1), pp. 5440. Date of Electronic Publication: 2023 Sep 06.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, N.I.H., Extramural

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Pharmacological hallmarks of allostery at the M4 muscarinic receptor elucidated through structure and dynamics.

Authors: Vuckovic Z Wang J Pham V et al.

Source: ELife [Elife] 2023 May 30; Vol. 12. Date of Electronic Publication: 2023 May 30.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE

The Prosperity and Adversity of M4 Muscarinic Acetylcholine Receptor Activators in the Treatment of Neuropsychiatric Disorders.

Authors: Liu B Christopoulos A Thal DM et al.

Source: Journal of medicinal chemistry [J Med Chem] 2025 Apr 24; Vol. 68 (8), pp. 7932-7954. Date of Electronic Publication: 2025 Apr 16.

Publication Type: Journal Article; Review

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE

Cryo-EM reveals a new allosteric binding site at the M5 mAChR.

Authors: Burger WAC Mobbs JI Rana B et al.

Source: BioRxiv : the preprint server for biology [bioRxiv] 2025 Feb 08. Date of Electronic Publication: 2025 Feb 08.

Publication Type: Journal Article; Preprint

Journal Info: Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet ISSN: 2692-8205 (Electronic) Linking ISSN: 26928205 NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE

Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges.

Authors: Kaoullas MG Thal DM Christopoulos A et al.

Source: Neuropharmacology [Neuropharmacology] 2024 Nov 01; Vol. 258, pp. 110092. Date of Electronic Publication: 2024 Jul 25.

Publication Type: Journal Article; Review; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Pergamon Press Country of Publication: England NLM ID: 0236217 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7064 (Electronic) Linking ISSN: 00283908 NLM ISO Abbreviation: Neuropharmacology Subsets: MEDLINE

Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gastrointestinal motility disorders.

Authors: DiCello JJ Carbone SE Saito A et al.

Source: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2022 Jan 01; Vol. 322 (1), pp. G66-G78. Date of Electronic Publication: 2021 Nov 10.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1547 (Electronic) Linking ISSN: 01931857 NLM ISO Abbreviation: Am J Physiol Gastrointest Liver Physiol Subsets: MEDLINE

Ligand-directed biased agonism at human histamine H3 receptor isoforms across Gαi/o- and β-arrestin2-mediated pathways.

Authors: Rahman SN Imhaouran F Leurs R et al.

Source: Biochemical pharmacology [Biochem Pharmacol] 2024 Oct; Vol. 228, pp. 115988. Date of Electronic Publication: 2023 Dec 28.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 0101032 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2968 (Electronic) Linking ISSN: 00062952 NLM ISO Abbreviation: Biochem Pharmacol Subsets: MEDLINE

Positive allosteric modulation of a GPCR ternary complex.

Authors: Burger WAC Draper-Joyce CJ Valant C et al.

Source: Science advances [Sci Adv] 2024 Sep 13; Vol. 10 (37), pp. eadp7040. Date of Electronic Publication: 2024 Sep 11.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101653440 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2375-2548 (Electronic) Linking ISSN: 23752548 NLM ISO Abbreviation: Sci Adv Subsets: MEDLINE

Discovery of 2-Methyl-5-(1H-pyrazol-4-yl)pyridines and Related Heterocycles as Promising M4 mAChR Positive Allosteric Modulators for the Treatment of Neurocognitive Disorders.

Authors: Liu B Thompson G Jörg M et al.

Source: Journal of medicinal chemistry [J Med Chem] 2024 Aug 08; Vol. 67 (15), pp. 13286-13304. Date of Electronic Publication: 2024 Jul 18.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE