Search Results - "Watterson DM"

The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target.

Authors: Borders AS de Almeida L Van Eldik LJ et al.

Source: BMC Neuroscience. 2008 Supplement 2, Vol. 9, pS12-S12. 1p.

Identification of p38 MAPK inhibition as a neuroprotective strategy for combinatorial SMA therapy.

Authors: Carlini MJ Espinoza-Derout J Van Alstyne M et al.

Source: EMBO molecular medicine [EMBO Mol Med] 2025 Oct; Vol. 17 (10), pp. 2762-2786. Date of Electronic Publication: 2025 Sep 08.

Publication Type: Journal Article

Journal Info: Publisher: EMBO Press Country of Publication: Germany NLM ID: 101487380 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1757-4684 (Electronic) Linking ISSN: 17574676 NLM ISO Abbreviation: EMBO Mol Med Subsets: MEDLINE

The Highly Selective 5-HT2B Receptor Antagonist MW073 Mitigates Aggressive Behavior in an Alzheimer's Disease Mouse Model.

Authors: Acquarone E Roy SM Staniszewski A et al.

Source: Cells [Cells] 2026 Feb 01; Vol. 15 (3). Date of Electronic Publication: 2026 Feb 01.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE

Optimized 5-HT2b inhibitors for neuropsychiatric syndromes with cognitive dysfunction.

Authors: Roy SM Acquarone E Argyrousi EK et al.

Source: Alzheimer's & dementia (New York, N. Y.) [Alzheimers Dement (N Y)] 2025 Mar 27; Vol. 11 (1), pp. e70073. Date of Electronic Publication: 2025 Mar 27 (Print Publication: 2025).

Publication Type: Journal Article

Journal Info: Publisher: Wiley on behalf of the Alzheimer's Association Country of Publication: United States NLM ID: 101650118 Publication Model: eCollection Cited Medium: Internet ISSN: 2352-8737 (Electronic) Linking ISSN: 23528737 NLM ISO Abbreviation: Alzheimers Dement (N Y) Subsets: PubMed not MEDLINE

USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I.

Authors: Liu K Iyer R Li Y et al.

Source: The Journal of clinical investigation [J Clin Invest] 2025 Nov 18; Vol. 136 (1). Date of Electronic Publication: 2025 Nov 18 (Print Publication: 2026).

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: American Society for Clinical Investigation Country of Publication: United States NLM ID: 7802877 Publication Model: eCollection Cited Medium: Internet ISSN: 1558-8238 (Electronic) Linking ISSN: 00219738 NLM ISO Abbreviation: J Clin Invest Subsets: MEDLINE

PI3Kγ stimulates a high molecular weight form of myosin light chain kinase to promote myeloid cell adhesion and tumor inflammation.

Authors: Schmid MC Kang SW Chen H et al.

Source: Nature communications [Nat Commun] 2022 Apr 01; Vol. 13 (1), pp. 1768. Date of Electronic Publication: 2022 Apr 01.

Publication Type: Journal Article

Journal Info: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE

Therapeutic treatment with the anti-inflammatory drug candidate MW151 may partially reduce memory impairment and normalizes hippocampal metabolic markers in a mouse model of comorbid amyloid and vascular pathology.

Authors: Braun DJ Powell DK McLouth CJ et al.

Source: PloS one [PLoS One] 2022 Jan 26; Vol. 17 (1), pp. e0262474. Date of Electronic Publication: 2022 Jan 26 (Print Publication: 2022).

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

The 5HT2b Receptor in Alzheimer's Disease: Increased Levels in Patient Brains and Antagonist Attenuation of Amyloid and Tau Induced Dysfunction.

Authors: Acquarone E Argyrousi EK Arancio O et al.

Source: Journal of Alzheimer's disease : JAD [J Alzheimers Dis] 2024; Vol. 98 (4), pp. 1349-1360.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: SAGE Publications Country of Publication: United States NLM ID: 9814863 Publication Model: Print Cited Medium: Internet ISSN: 1875-8908 (Electronic) Linking ISSN: 13872877 NLM ISO Abbreviation: J Alzheimers Dis Subsets: MEDLINE

Genetic knockout of myosin light chain kinase (MLCK210) prevents cerebral microhemorrhages and attenuates neuroinflammation in a mouse model of vascular cognitive impairment and dementia.

Authors: Braun DJ Bachstetter AD Sudduth TL et al.

Source: GeroScience [Geroscience] 2019 Oct; Vol. 41 (5), pp. 671-679. Date of Electronic Publication: 2019 May 19.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Springer International Publishing Country of Publication: Switzerland NLM ID: 101686284 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2509-2723 (Electronic) Linking ISSN: 25092723 NLM ISO Abbreviation: Geroscience Subsets: MEDLINE

Phosphorylation-dependent subcellular redistribution of small myosin light chain kinase.

Authors: Khapchaev AY Watterson DM Shirinsky VP

Source: Biochimica et biophysica acta. Molecular cell research [Biochim Biophys Acta Mol Cell Res] 2021 Oct; Vol. 1868 (11), pp. 119104. Date of Electronic Publication: 2021 Jul 22.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101731731 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-2596 (Electronic) Linking ISSN: 01674889 NLM ISO Abbreviation: Biochim Biophys Acta Mol Cell Res Subsets: MEDLINE

MW151 Inhibited IL-1β Levels after Traumatic Brain Injury with No Effect on Microglia Physiological Responses.

Authors: Bachstetter AD Zhou Z Rowe RK et al.

Source: PloS one [PLoS One] 2016 Feb 12; Vol. 11 (2), pp. e0149451. Date of Electronic Publication: 2016 Feb 12 (Print Publication: 2016).

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE

Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis.

Authors: Nighot P Al-Sadi R Rawat M et al.

Source: American journal of physiology. Gastrointestinal and liver physiology [Am J Physiol Gastrointest Liver Physiol] 2015 Dec 15; Vol. 309 (12), pp. G988-97. Date of Electronic Publication: 2015 Oct 29.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.

Journal Info: Publisher: American Physiological Society Country of Publication: United States NLM ID: 100901227 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1522-1547 (Electronic) Linking ISSN: 01931857 NLM ISO Abbreviation: Am J Physiol Gastrointest Liver Physiol Subsets: MEDLINE

Phosphorylation Regulates Interaction of 210-kDa Myosin Light Chain Kinase N-terminal Domain with Actin Cytoskeleton.

Authors: Vilitkevich EL Khapchaev AY Kudryashov DS et al.

Source: Biochemistry. Biokhimiia [Biochemistry (Mosc)] 2015 Oct; Vol. 80 (10), pp. 1288-97.

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

Journal Info: Publisher: MAIK Nauka/Interperiodica Country of Publication: United States NLM ID: 0376536 Publication Model: Print Cited Medium: Internet ISSN: 1608-3040 (Electronic) Linking ISSN: 00062979 NLM ISO Abbreviation: Biochemistry (Mosc) Subsets: MEDLINE

First-in-Human Studies of MW01-6-189WH, a Brain-Penetrant, Antineuroinflammatory Small-Molecule Drug Candidate: Phase 1 Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Studies in Healthy Adult Volunteers.

Authors: Van Eldik LJ Sawaki L Bowen K et al.

Source: Clinical pharmacology in drug development [Clin Pharmacol Drug Dev] 2021 Feb; Vol. 10 (2), pp. 131-143. Date of Electronic Publication: 2020 Apr 07.

Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Wiley Country of Publication: United States NLM ID: 101572899 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2160-7648 (Electronic) Linking ISSN: 2160763X NLM ISO Abbreviation: Clin Pharmacol Drug Dev Subsets: MEDLINE

Correction to "A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction".

Authors: Roy SM Minasov G Arancio O et al.

Source: Journal of medicinal chemistry [J Med Chem] 2020 Aug 13; Vol. 63 (15), pp. 8649. Date of Electronic Publication: 2020 Jul 16.

Publication Type: Published Erratum

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE; PubMed not MEDLINE

Involvement of p38 MAPK in Synaptic Function and Dysfunction.

Authors: Falcicchia C Tozzi F Arancio O et al.

Source: International journal of molecular sciences [Int J Mol Sci] 2020 Aug 06; Vol. 21 (16). Date of Electronic Publication: 2020 Aug 06.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE

Closed head injury in an age-related Alzheimer mouse model leads to an altered neuroinflammatory response and persistent cognitive impairment.

Authors: Webster SJ Van Eldik LJ Watterson DM et al.

Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2015 Apr 22; Vol. 35 (16), pp. 6554-69.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

An anti-neuroinflammatory that targets dysregulated glia enhances the efficacy of CNS-directed gene therapy in murine infantile neuronal ceroid lipofuscinosis.

Authors: Macauley SL Wong AM Shyng C et al.

Source: The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 2014 Sep 24; Vol. 34 (39), pp. 13077-82.

Publication Type: Journal Article

Journal Info: Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE

Target engagement analysis and link to pharmacodynamic endpoint for a novel class of CNS-penetrant and efficacious p38α MAPK inhibitors.

Authors: Bachstetter AD Watterson DM Van Eldik LJ

Source: Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology [J Neuroimmune Pharmacol] 2014 Sep; Vol. 9 (4), pp. 454-60. Date of Electronic Publication: 2014 May 01.

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

Journal Info: Publisher: Springer Science + Business Media Country of Publication: United States NLM ID: 101256586 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-1904 (Electronic) Linking ISSN: 15571890 NLM ISO Abbreviation: J Neuroimmune Pharmacol Subsets: MEDLINE

Generation and behavior characterization of CaMKIIβ knockout mice.

Authors: Bachstetter AD Webster SJ Tu T et al.

Source: PloS one [PLoS One] 2014 Aug 15; Vol. 9 (8), pp. e105191. Date of Electronic Publication: 2014 Aug 15 (Print Publication: 2014).

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE