Search Results - "Wong-Roushar J"

Serine Hydroxymethyltransferase (SHMT) in biology and disease: molecular mechanisms and therapeutic targeting.

Authors: Li JY Zhang XQ Sheng R

Source: Journal of translational medicine [J Transl Med] 2026 Apr 21; Vol. 24 (1). Date of Electronic Publication: 2026 Apr 21.

Publication Type: Journal Article; Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

Ribosomal frameshifting selectively modulates the assembly, function, and pharmacological rescue of a misfolded CFTR variant.

Authors: Carmody PJ Roushar FJ Tedman A et al.

Source: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 Oct 15; Vol. 121 (42), pp. e2414768121. Date of Electronic Publication: 2024 Oct 10.

Publication Type: Journal Article; Research Support, N.I.H., Extramural

Journal Info: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE

Metabolic Vulnerabilities as a Therapeutic Target in Breast Cancer.

Authors: Guo, Sabrina Addison, Christina L.

Source: Current Oncology. Feb2026, Vol. 31 Issue 2, p129. 34p.

Multitargeted 6-Substituted Thieno[2,3-d]pyrimidines as Folate Receptor-Selective Anticancer Agents that Inhibit Cytosolic and Mitochondrial One-Carbon Metabolism.

Authors: Tong N Wong-Roushar J Wallace-Povirk A et al.

Source: ACS pharmacology & translational science [ACS Pharmacol Transl Sci] 2023 Apr 26; Vol. 6 (5), pp. 748-770. Date of Electronic Publication: 2023 Apr 26 (Print Publication: 2023).

Publication Type: Journal Article

Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101721411 Publication Model: eCollection Cited Medium: Internet ISSN: 2575-9108 (Electronic) Linking ISSN: 25759108 NLM ISO Abbreviation: ACS Pharmacol Transl Sci Subsets: PubMed not MEDLINE

SHMT2 inhibition triggers mitochondrial apoptosis to suppress lung adenocarcinoma progression.

Authors: Chen Y Zhang X Pang X et al.

Source: Journal of translational medicine [J Transl Med] 2026 Mar 11; Vol. 24 (1). Date of Electronic Publication: 2026 Mar 11.

Publication Type: Journal Article

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101190741 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-5876 (Electronic) Linking ISSN: 14795876 NLM ISO Abbreviation: J Transl Med Subsets: MEDLINE

Cystic Fibrosis Modulator Therapies: Bridging Insights from CF to other Membrane Protein Misfolding Diseases.

Authors: Kim, Minsoo Plate, Lars

Source: Israel Journal of Chemistry. Dec2024, Vol. 64 Issue 12, p1-18. 18p.

MYCN and Metabolic Reprogramming in Neuroblastoma.

Authors: Bansal, Mohit Gupta, Anamika Ding, Han-Fei

Source: Cancers. Sep2022, Vol. 14 Issue 17, p4113. 24p.

Mitochondrial adaptation in cancer drug resistance: prevalence, mechanisms, and management.

Authors: Jin, Ping Jiang, Jingwen Zhou, Li et al.

Source: Journal of Hematology & Oncology. 7/18/2022, Vol. 15 Issue 1, p1-42. 42p.

Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer.

Authors: Wallace-Povirk, Adrianne Hou, Zhanjun Nayeen, Md. Junayed et al.

Source: Cancers. Jan2022, Vol. 14 Issue 1, p191. 1p.

Mechanisms of Metabolic Reprogramming in Cancer Cells Supporting Enhanced Growth and Proliferation.

Authors: Schiliro, Chelsea Firestein, Bonnie L. Ohta, Kunimasa

Source: Cells (2073-4409). May2021, Vol. 10 Issue 5, p1056. 1p.

A journey into the regulatory secrets of the de novo purine nucleotide biosynthesis.

Authors: Ayoub N Gedeon A Munier-Lehmann H

Source: Frontiers in pharmacology [Front Pharmacol] 2024 Feb 20; Vol. 15, pp. 1329011. Date of Electronic Publication: 2024 Feb 20 (Print Publication: 2024).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

Serine-associated one-carbon metabolic reprogramming: a new anti-cancer therapeutic strategy.

Authors: Zhang J Bai J Gong C et al.

Source: Frontiers in oncology [Front Oncol] 2023 Aug 18; Vol. 13, pp. 1184626. Date of Electronic Publication: 2023 Aug 18 (Print Publication: 2023).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE

The connection between innervation and metabolic rearrangements in pancreatic cancer through serine.

Authors: Dong M Cao L Cui R et al.

Source: Frontiers in oncology [Front Oncol] 2022 Dec 13; Vol. 12, pp. 992927. Date of Electronic Publication: 2022 Dec 13 (Print Publication: 2022).

Publication Type: Journal Article; Review

Journal Info: Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101568867 Publication Model: eCollection Cited Medium: Print ISSN: 2234-943X (Print) Linking ISSN: 2234943X NLM ISO Abbreviation: Front Oncol Subsets: PubMed not MEDLINE

Pharmacokinetics, bioavailability, and plasma protein binding study of glytrexate, a novel multitarget antifolate.

Authors: Xiang J Wu M Wang J et al.

Source: Frontiers in pharmacology [Front Pharmacol] 2022 Oct 04; Vol. 13, pp. 1001308. Date of Electronic Publication: 2022 Oct 04 (Print Publication: 2022).

Publication Type: Journal Article

Journal Info: Publisher: Frontiers Media] Country of Publication: Switzerland NLM ID: 101548923 Publication Model: eCollection Cited Medium: Print ISSN: 1663-9812 (Print) Linking ISSN: 16639812 NLM ISO Abbreviation: Front Pharmacol Subsets: PubMed not MEDLINE

Multifaceted roles of mitochondrial dysfunction in diseases: from powerhouses to saboteurs.

Authors: Prabhu SS Nair AS Nirmala SV

Source: Archives of pharmacal research [Arch Pharm Res] 2023 Oct; Vol. 46 (9-10), pp. 723-743. Date of Electronic Publication: 2023 Sep 26.

Publication Type: Journal Article; Review

Journal Info: Publisher: Pharmaceutical Society of Korea Country of Publication: Korea (South) NLM ID: 8000036 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1976-3786 (Electronic) Linking ISSN: 02536269 NLM ISO Abbreviation: Arch Pharm Res Subsets: MEDLINE

In Silico Prediction of Metabolic Fluxes in Cancer Cells with Altered S-adenosylmethionine Decarboxylase Activity.

Authors: Dotsenko O Shtofel D

Source: Cell biochemistry and biophysics [Cell Biochem Biophys] 2021 Mar; Vol. 79 (1), pp. 37-48. Date of Electronic Publication: 2020 Oct 11.

Publication Type: Journal Article

Journal Info: Publisher: Humana Press Country of Publication: United States NLM ID: 9701934 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1559-0283 (Electronic) Linking ISSN: 10859195 NLM ISO Abbreviation: Cell Biochem Biophys Subsets: MEDLINE

Sickle Cell Disease: Current Drug Treatments and Functional Foods with Therapeutic Potential.

Authors: Gonçalves E Smaoui S Brito M et al.

Source: Current issues in molecular biology [Curr Issues Mol Biol] 2024 Jun 12; Vol. 46 (6), pp. 5845-5865. Date of Electronic Publication: 2024 Jun 12.

Publication Type: Journal Article; Review

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100931761 Publication Model: Electronic Cited Medium: Internet ISSN: 1467-3045 (Electronic) Linking ISSN: 14673037 NLM ISO Abbreviation: Curr Issues Mol Biol Subsets: PubMed not MEDLINE

Targeting serine-glycine-one-carbon metabolism as a vulnerability in cancers.

Authors: Sun W Liu R Gao X et al.

Source: Biomarker research [Biomark Res] 2023 May 05; Vol. 11 (1), pp. 48. Date of Electronic Publication: 2023 May 05.

Publication Type: Journal Article; Review

Journal Info: Publisher: BioMed Central Country of Publication: England NLM ID: 101607860 Publication Model: Electronic Cited Medium: Print ISSN: 2050-7771 (Print) Linking ISSN: 20507771 NLM ISO Abbreviation: Biomark Res Subsets: PubMed not MEDLINE

Discovery of Myeloid-Derived Suppressor Cell-Specific Metabolism by Metabolomic and Lipidomic Profiling.

Authors: Kim J Lee H Choi HK et al.

Source: Metabolites [Metabolites] 2023 Mar 27; Vol. 13 (4). Date of Electronic Publication: 2023 Mar 27.

Publication Type: Journal Article

Journal Info: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101578790 Publication Model: Electronic Cited Medium: Print ISSN: 2218-1989 (Print) Linking ISSN: 22181989 NLM ISO Abbreviation: Metabolites Subsets: PubMed not MEDLINE