View in EDS HTML Full Text PDF Full Text

Markers of Inflammation and Coagulation after Long-Term Exposure to Coarse Particulate Matter: A Cross-Sectional Analysis from the Multi-Ethnic Study of Atherosclerosis.

Saved in:
Bibliographic Details
Title: Markers of Inflammation and Coagulation after Long-Term Exposure to Coarse Particulate Matter: A Cross-Sectional Analysis from the Multi-Ethnic Study of Atherosclerosis.
Authors: Adar, Sara D.1 sadar@umich.edu, D'Souza, Jennifer1, Mendelsohn-Victor, Kari1, Jacobs Jr., David R.2, Cushman, Mary3,4, Sheppard, Lianne5,6, Thorne, Peter S.7, Burke, Gregory L.8, Daviglus, Martha L.9,10, Szpiro, Adam A.6, Roux, Ana V. Diez1, Kaufman, Joel D.5,11,12, Larson, Timothy V.5,13
Source: Environmental Health Perspectives. Jun2015, Vol. 123 Issue 6, p541-548. 8p. 1 Chart, 3 Graphs.
Subject Terms: *Biomarkers, *Copper, *Particulate matter, Blood coagulation, Inflammation, Confidence intervals, Endotoxins, Enzyme-linked immunosorbent assay, Medical cooperation, Research, Research funding, Multiple regression analysis, Cross-sectional method, Data analysis software, Descriptive statistics
Geographic Terms: United States
Abstract: Background: Toxicological research suggests that coarse particles (PM10-2.5) are inflammatory, but responses are complex and may be best summarized by multiple inflammatory markers. Few human studies have investigated associations with PM10-2.5 and, of those, none have explored longterm exposures. Here we examine long-term associations with inflammation and coagulation in the Multi-Ethnic Study of Atherosclerosis. Methods: Participants included 3,295 adults (45-84 years of age) from three metropolitan areas. Site-specific spatial models were used to estimate 5-year concentrations of PM10-2.5 mass and copper, zinc, phosphorus, silicon, and endotoxin found in PM10-2.5. Outcomes included interleukin-6, C-reactive protein, fibrinogen, total homocysteine, D-dimer, factor VIII, plasmin- antiplasmin complex, and inflammation and coagulation scores. We used multivariable regression with multiply imputed data to estimate associations while controlling for potential confounders, including co-pollutants such as fine particulate matter. Results: Some limited evidence was found of relationships between inflammation and coagulation and PM10-2.5. Endotoxin was the PM10-2.5 component most strongly associated with inflammation, with an interquartile range (IQR) increase (0.08 EU/m3) associated with 0.15 (95% CI: 0.01, 0.28; p = 0.03) and 0.08 (95% CI: -0.07, 0.23; p = 0.28) higher inflammation scores before and after control for city, respectively. Copper was the component with the strongest association with coagulation, with a 4-ng/m3 increase associated with 0.19 (95% CI: 0.08, 0.30; p = 0.0008) and 0.12 (95% CI: -0.05, 0.30; p = 0.16) unit higher coagulation scores before and after city adjustment, respectively. Conclusions: Our cross-sectional analysis provided some evidence that long-term PM10-2.5 exposure was associated with inflammation and coagulation, but associations were modest and depended on particle composition. Citation: Adar SD, D'Souza J, Mendelsohn-Victor K, Jacobs DR Jr, Cushman M, Sheppard L, Thorne PS, Burke GL, Daviglus ML, Szpiro AA, Diez Roux AV, Kaufman JD, Larson TV. 2015. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: GreenFILE
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: 8gh
DbLabel: GreenFILE
An: 103119689
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Markers of Inflammation and Coagulation after Long-Term Exposure to Coarse Particulate Matter: A Cross-Sectional Analysis from the Multi-Ethnic Study of Atherosclerosis.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Adar%2C+Sara+D%2E%22">Adar, Sara D.</searchLink><relatesTo>1</relatesTo><i> sadar@umich.edu</i><br /><searchLink fieldCode="AR" term="%22D'Souza%2C+Jennifer%22">D'Souza, Jennifer</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Mendelsohn-Victor%2C+Kari%22">Mendelsohn-Victor, Kari</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Jacobs+Jr%2E%2C+David+R%2E%22">Jacobs Jr., David R.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Cushman%2C+Mary%22">Cushman, Mary</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Sheppard%2C+Lianne%22">Sheppard, Lianne</searchLink><relatesTo>5,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Thorne%2C+Peter+S%2E%22">Thorne, Peter S.</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Burke%2C+Gregory+L%2E%22">Burke, Gregory L.</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Daviglus%2C+Martha+L%2E%22">Daviglus, Martha L.</searchLink><relatesTo>9,10</relatesTo><br /><searchLink fieldCode="AR" term="%22Szpiro%2C+Adam+A%2E%22">Szpiro, Adam A.</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Roux%2C+Ana+V%2E+Diez%22">Roux, Ana V. Diez</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kaufman%2C+Joel+D%2E%22">Kaufman, Joel D.</searchLink><relatesTo>5,11,12</relatesTo><br /><searchLink fieldCode="AR" term="%22Larson%2C+Timothy+V%2E%22">Larson, Timothy V.</searchLink><relatesTo>5,13</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Jun2015, Vol. 123 Issue 6, p541-548. 8p. 1 Chart, 3 Graphs.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br />*<searchLink fieldCode="DE" term="%22Copper%22">Copper</searchLink><br />*<searchLink fieldCode="DE" term="%22Particulate+matter%22">Particulate matter</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+coagulation%22">Blood coagulation</searchLink><br /><searchLink fieldCode="DE" term="%22Inflammation%22">Inflammation</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Endotoxins%22">Endotoxins</searchLink><br /><searchLink fieldCode="DE" term="%22Enzyme-linked+immunosorbent+assay%22">Enzyme-linked immunosorbent assay</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Multiple+regression+analysis%22">Multiple regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22United+States%22">United States</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Background: Toxicological research suggests that coarse particles (PM10-2.5) are inflammatory, but responses are complex and may be best summarized by multiple inflammatory markers. Few human studies have investigated associations with PM10-2.5 and, of those, none have explored longterm exposures. Here we examine long-term associations with inflammation and coagulation in the Multi-Ethnic Study of Atherosclerosis. Methods: Participants included 3,295 adults (45-84 years of age) from three metropolitan areas. Site-specific spatial models were used to estimate 5-year concentrations of PM10-2.5 mass and copper, zinc, phosphorus, silicon, and endotoxin found in PM10-2.5. Outcomes included interleukin-6, C-reactive protein, fibrinogen, total homocysteine, D-dimer, factor VIII, plasmin- antiplasmin complex, and inflammation and coagulation scores. We used multivariable regression with multiply imputed data to estimate associations while controlling for potential confounders, including co-pollutants such as fine particulate matter. Results: Some limited evidence was found of relationships between inflammation and coagulation and PM10-2.5. Endotoxin was the PM10-2.5 component most strongly associated with inflammation, with an interquartile range (IQR) increase (0.08 EU/m3) associated with 0.15 (95% CI: 0.01, 0.28; p = 0.03) and 0.08 (95% CI: -0.07, 0.23; p = 0.28) higher inflammation scores before and after control for city, respectively. Copper was the component with the strongest association with coagulation, with a 4-ng/m3 increase associated with 0.19 (95% CI: 0.08, 0.30; p = 0.0008) and 0.12 (95% CI: -0.05, 0.30; p = 0.16) unit higher coagulation scores before and after city adjustment, respectively. Conclusions: Our cross-sectional analysis provided some evidence that long-term PM10-2.5 exposure was associated with inflammation and coagulation, but associations were modest and depended on particle composition. Citation: Adar SD, D'Souza J, Mendelsohn-Victor K, Jacobs DR Jr, Cushman M, Sheppard L, Thorne PS, Burke GL, Daviglus ML, Szpiro AA, Diez Roux AV, Kaufman JD, Larson TV. 2015. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=103119689
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1289/ehp.1308069
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 8
        StartPage: 541
    Subjects:
      – SubjectFull: Biomarkers
        Type: general
      – SubjectFull: Copper
        Type: general
      – SubjectFull: Particulate matter
        Type: general
      – SubjectFull: Blood coagulation
        Type: general
      – SubjectFull: Inflammation
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Endotoxins
        Type: general
      – SubjectFull: Enzyme-linked immunosorbent assay
        Type: general
      – SubjectFull: Medical cooperation
        Type: general
      – SubjectFull: Research
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Multiple regression analysis
        Type: general
      – SubjectFull: Cross-sectional method
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: United States
        Type: general
    Titles:
      – TitleFull: Markers of Inflammation and Coagulation after Long-Term Exposure to Coarse Particulate Matter: A Cross-Sectional Analysis from the Multi-Ethnic Study of Atherosclerosis.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Adar, Sara D.
      – PersonEntity:
          Name:
            NameFull: D'Souza, Jennifer
      – PersonEntity:
          Name:
            NameFull: Mendelsohn-Victor, Kari
      – PersonEntity:
          Name:
            NameFull: Jacobs Jr., David R.
      – PersonEntity:
          Name:
            NameFull: Cushman, Mary
      – PersonEntity:
          Name:
            NameFull: Sheppard, Lianne
      – PersonEntity:
          Name:
            NameFull: Thorne, Peter S.
      – PersonEntity:
          Name:
            NameFull: Burke, Gregory L.
      – PersonEntity:
          Name:
            NameFull: Daviglus, Martha L.
      – PersonEntity:
          Name:
            NameFull: Szpiro, Adam A.
      – PersonEntity:
          Name:
            NameFull: Roux, Ana V. Diez
      – PersonEntity:
          Name:
            NameFull: Kaufman, Joel D.
      – PersonEntity:
          Name:
            NameFull: Larson, Timothy V.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2015
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-print
              Value: 00916765
          Numbering:
            – Type: volume
              Value: 123
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Environmental Health Perspectives
              Type: main
ResultId 1