Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004.
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| Title: | Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. |
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| Authors: | Laclaustra M (AUTHOR), Navas-Acien A (AUTHOR), Stranges S (AUTHOR), Ordovas JM (AUTHOR), Guallar E (AUTHOR) |
| Source: | Environmental Health Perspectives. Sep2009, Vol. 117 Issue 9, p1409-1413. 5p. |
| Abstract: | BACKGROUND: Increasing evidence suggests that high selenium levels are associated with diabetes and other cardiometabolic risk factors. OBJECTIVES: We evaluated the association of serum selenium concentrations with fasting plasma glucose, glycosylated hemoglobin levels, and diabetes in the most recently available representative sample of the U.S. population. METHODS: We used a cross-sectional analysis of 917 adults > or = 40 years of age who had a fasting morning blood sample in the National Health and Nutrition Examination Survey 2003-2004. We evaluated the association of serum selenium, measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry, and diabetes, defined as a self-report of current use of hypoglycemic agents or insulin or as fasting plasma glucose > or = 126 mg/dL. RESULTS: Mean serum selenium was 137.1 microg/L. The multivariable adjusted odds ratio [95% confidence interval (CI)] for diabetes comparing the highest quartile of serum selenium (> or = 147 microg/L) with the lowest (< 124 microg/L) was 7.64 (3.34-17.46). The corresponding average differences (95% CI) in fasting plasma glucose and glycosylated hemoglobin were 9.5 mg/dL (3.4-15.6 mg/dL) and 0.30% (0.14-0.46%), respectively. In spline regression models, the prevalence of diabetes as well as glucose and glycosylated hemoglobin levels increased with increasing selenium concentrations up to 160 microg/L. CONCLUSIONS: In U.S. adults, high serum selenium concentrations were associated with higher prevalence of diabetes and higher fasting plasma glucose and glycosylated hemoglobin levels. Given high selenium intake in the U.S. population, further research is needed to determine the role of excess selenium levels in the development or the progression of diabetes. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| URL: | 44202796 |
| Database: | GreenFILE |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 105434166 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Laclaustra+M%22">Laclaustra M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Navas-Acien+A%22">Navas-Acien A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stranges+S%22">Stranges S</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ordovas+JM%22">Ordovas JM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Guallar+E%22">Guallar E</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Sep2009, Vol. 117 Issue 9, p1409-1413. 5p. – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: Increasing evidence suggests that high selenium levels are associated with diabetes and other cardiometabolic risk factors. OBJECTIVES: We evaluated the association of serum selenium concentrations with fasting plasma glucose, glycosylated hemoglobin levels, and diabetes in the most recently available representative sample of the U.S. population. METHODS: We used a cross-sectional analysis of 917 adults > or = 40 years of age who had a fasting morning blood sample in the National Health and Nutrition Examination Survey 2003-2004. We evaluated the association of serum selenium, measured by inductively coupled plasma-dynamic reaction cell-mass spectrometry, and diabetes, defined as a self-report of current use of hypoglycemic agents or insulin or as fasting plasma glucose > or = 126 mg/dL. RESULTS: Mean serum selenium was 137.1 microg/L. The multivariable adjusted odds ratio [95% confidence interval (CI)] for diabetes comparing the highest quartile of serum selenium (> or = 147 microg/L) with the lowest (< 124 microg/L) was 7.64 (3.34-17.46). The corresponding average differences (95% CI) in fasting plasma glucose and glycosylated hemoglobin were 9.5 mg/dL (3.4-15.6 mg/dL) and 0.30% (0.14-0.46%), respectively. In spline regression models, the prevalence of diabetes as well as glucose and glycosylated hemoglobin levels increased with increasing selenium concentrations up to 160 microg/L. CONCLUSIONS: In U.S. adults, high serum selenium concentrations were associated with higher prevalence of diabetes and higher fasting plasma glucose and glycosylated hemoglobin levels. Given high selenium intake in the U.S. population, further research is needed to determine the role of excess selenium levels in the development or the progression of diabetes. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) – Name: URL Label: URL Group: URL Data: <link linkTarget="URL" linkTerm="44202796" linkWindow="_blank">44202796</link> |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1289/ehp.0900704 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 1409 Titles: – TitleFull: Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Laclaustra M – PersonEntity: Name: NameFull: Navas-Acien A – PersonEntity: Name: NameFull: Stranges S – PersonEntity: Name: NameFull: Ordovas JM – PersonEntity: Name: NameFull: Guallar E IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 00916765 Numbering: – Type: volume Value: 117 – Type: issue Value: 9 Titles: – TitleFull: Environmental Health Perspectives Type: main |
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