Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors [corrected] [published erratum appears in ENVIRON HEALTH PERSPECT 2009 Oct;117(10):A 434].
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| Title: | Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors [corrected] [published erratum appears in ENVIRON HEALTH PERSPECT 2009 Oct;117(10):A 434]. |
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| Authors: | La Merrill M (AUTHOR), Kuruvilla BS (AUTHOR), Pomp D (AUTHOR), Birnbaum LS (AUTHOR), Threadgill DW (AUTHOR) |
| Source: | Environmental Health Perspectives. Sep2009, Vol. 117 Issue 9, p1414-1419. 6p. |
| Abstract: | BACKGROUND: Increased fat intake is associated with obesity and may make obese individuals uniquely susceptible to the effects of lipophilic aryl hydrocarbon receptor (AHR) ligands. OBJECTIVES: We investigated the consequences of high-fat diet (HFD) and AHR ligands on body composition, mammary development, and hepatic P450 expression. METHODS: Pregnant C57BL/6J (B6) and DBA/2J (D2) dams, respectively expressing high- or low-responsive AHR, were dosed at mid-gestation with TCDD. At parturition, mice were placed on an HFD or a low-fat diet (LFD). Body fat of progeny was measured before dosing with 7,12-dimethylbenz[a]anthracene (DMBA). Fasting blood glucose was measured, and liver and mammary glands were analyzed. RESULTS: Maternal TCDD exposure resulted in reduced litter size in D2 mice and, on HFD, reduced postpartum survival in B6 mice. In D2 mice, HFD increased body mass and fat in off-spring, induced precocious mammary gland development, and increased AHR expression compared with mice given an LFD. Maternal TCDD exposure increased hepatic Cyp1a1 and Cyp1b1 expression in offspring on both diets, but DMBA depressed Cyp1b1 expression only in mice fed an HFD. In D2 progeny, TCDD exposure decreased mammary terminal end bud size, and DMBA exposure decreased the number of terminal end buds. Only in D2 progeny fed HFD did perinatal TCDD increase blood glucose and the size of mammary fat pads, while decreasing both branch elongation and the number of terminal end buds. CONCLUSIONS: We conclude that despite having a low-responsive AHR, D2 progeny fed a diet similar to that consumed by most people are susceptible to TCDD and DMBA exposure effects blood glucose levels, mammary differentiation, and hepatic Cyp1 expression. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| URL: | 44202560 |
| Database: | GreenFILE |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 105434168 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors [corrected] [published erratum appears in ENVIRON HEALTH PERSPECT 2009 Oct;117(10):A 434]. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22La+Merrill+M%22">La Merrill M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kuruvilla+BS%22">Kuruvilla BS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pomp+D%22">Pomp D</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Birnbaum+LS%22">Birnbaum LS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Threadgill+DW%22">Threadgill DW</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Sep2009, Vol. 117 Issue 9, p1414-1419. 6p. – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: Increased fat intake is associated with obesity and may make obese individuals uniquely susceptible to the effects of lipophilic aryl hydrocarbon receptor (AHR) ligands. OBJECTIVES: We investigated the consequences of high-fat diet (HFD) and AHR ligands on body composition, mammary development, and hepatic P450 expression. METHODS: Pregnant C57BL/6J (B6) and DBA/2J (D2) dams, respectively expressing high- or low-responsive AHR, were dosed at mid-gestation with TCDD. At parturition, mice were placed on an HFD or a low-fat diet (LFD). Body fat of progeny was measured before dosing with 7,12-dimethylbenz[a]anthracene (DMBA). Fasting blood glucose was measured, and liver and mammary glands were analyzed. RESULTS: Maternal TCDD exposure resulted in reduced litter size in D2 mice and, on HFD, reduced postpartum survival in B6 mice. In D2 mice, HFD increased body mass and fat in off-spring, induced precocious mammary gland development, and increased AHR expression compared with mice given an LFD. Maternal TCDD exposure increased hepatic Cyp1a1 and Cyp1b1 expression in offspring on both diets, but DMBA depressed Cyp1b1 expression only in mice fed an HFD. In D2 progeny, TCDD exposure decreased mammary terminal end bud size, and DMBA exposure decreased the number of terminal end buds. Only in D2 progeny fed HFD did perinatal TCDD increase blood glucose and the size of mammary fat pads, while decreasing both branch elongation and the number of terminal end buds. CONCLUSIONS: We conclude that despite having a low-responsive AHR, D2 progeny fed a diet similar to that consumed by most people are susceptible to TCDD and DMBA exposure effects blood glucose levels, mammary differentiation, and hepatic Cyp1 expression. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) – Name: URL Label: URL Group: URL Data: <link linkTarget="URL" linkTerm="44202560" linkWindow="_blank">44202560</link> |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1289/ehp.0800530 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 6 StartPage: 1414 Titles: – TitleFull: Dietary fat alters body composition, mammary development, and cytochrome p450 induction after maternal TCDD exposure in DBA/2J mice with low-responsive aryl hydrocarbon receptors [corrected] [published erratum appears in ENVIRON HEALTH PERSPECT 2009 Oct;117(10):A 434]. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: La Merrill M – PersonEntity: Name: NameFull: Kuruvilla BS – PersonEntity: Name: NameFull: Pomp D – PersonEntity: Name: NameFull: Birnbaum LS – PersonEntity: Name: NameFull: Threadgill DW IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 09 Text: Sep2009 Type: published Y: 2009 Identifiers: – Type: issn-print Value: 00916765 Numbering: – Type: volume Value: 117 – Type: issue Value: 9 Titles: – TitleFull: Environmental Health Perspectives Type: main |
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