Glutathione s-transferase p1, maternal smoking, and asthma in children: a haplotype-based analysis.
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| Title: | Glutathione s-transferase p1, maternal smoking, and asthma in children: a haplotype-based analysis. |
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| Authors: | Li YF (AUTHOR), Gauderman WJ (AUTHOR), Conti DV (AUTHOR), Lin PC (AUTHOR), Avol E (AUTHOR), Gilliland FD (AUTHOR) |
| Source: | Environmental Health Perspectives. Mar2008, Vol. 116 Issue 3, p409-415. 7p. |
| Abstract: | BACKGROUND: Glutathione S-transferase P1 (GSTP1) plays a role in a spectrum of respiratory diseases; however, the effects of sequence variation across the entire locus in asthma pathogenesis have yet to be determined. OBJECTIVES: This study was designed to investigate whether sequence variations in the GSTP1 coding and promoter regions are associated with asthma and wheezing outcomes and to determine whether variants affect susceptibility to maternal smoking. METHODS: Four haplotype tagging SNPs were selected that accounted for 83% of the common haplotypic variation in GSTP1. The associations of GSTP1 variants with asthma and wheezing were assessed among white children in the Children's Health Study (CHS). RESULTS: The Ile105Val allele and a SNP in the upstream promoter region (SNP1: rs6591255, putative transcription factor 1 binding site) were associated with asthma and wheezing outcomes, an association observed in two cohorts of the CHS recruited in different years. Haplotypes that included both the promoter SNP (i.e., rs6591255) and the 105 Val variant were associated with an increased risk for asthma in non-Hispanic whites. Using SNP- and haplotype-based approaches, the effect of maternal smoking on wheezing was largest in children with the Ile105Val allele. CONCLUSIONS: Variants in both the promoter and coding regions of the GSTP1 locus may contribute to the occurrence of childhood asthma and wheezing and may increase susceptibility to adverse effects of tobacco-smoke exposure. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| URL: | 31375495 |
| Database: | GreenFILE |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 105725454 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Glutathione s-transferase p1, maternal smoking, and asthma in children: a haplotype-based analysis. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Li+YF%22">Li YF</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gauderman+WJ%22">Gauderman WJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Conti+DV%22">Conti DV</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin+PC%22">Lin PC</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Avol+E%22">Avol E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gilliland+FD%22">Gilliland FD</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Mar2008, Vol. 116 Issue 3, p409-415. 7p. – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: Glutathione S-transferase P1 (GSTP1) plays a role in a spectrum of respiratory diseases; however, the effects of sequence variation across the entire locus in asthma pathogenesis have yet to be determined. OBJECTIVES: This study was designed to investigate whether sequence variations in the GSTP1 coding and promoter regions are associated with asthma and wheezing outcomes and to determine whether variants affect susceptibility to maternal smoking. METHODS: Four haplotype tagging SNPs were selected that accounted for 83% of the common haplotypic variation in GSTP1. The associations of GSTP1 variants with asthma and wheezing were assessed among white children in the Children's Health Study (CHS). RESULTS: The Ile105Val allele and a SNP in the upstream promoter region (SNP1: rs6591255, putative transcription factor 1 binding site) were associated with asthma and wheezing outcomes, an association observed in two cohorts of the CHS recruited in different years. Haplotypes that included both the promoter SNP (i.e., rs6591255) and the 105 Val variant were associated with an increased risk for asthma in non-Hispanic whites. Using SNP- and haplotype-based approaches, the effect of maternal smoking on wheezing was largest in children with the Ile105Val allele. CONCLUSIONS: Variants in both the promoter and coding regions of the GSTP1 locus may contribute to the occurrence of childhood asthma and wheezing and may increase susceptibility to adverse effects of tobacco-smoke exposure. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) – Name: URL Label: URL Group: URL Data: <link linkTarget="URL" linkTerm="31375495" linkWindow="_blank">31375495</link> |
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| RecordInfo | BibRecord: BibEntity: Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 409 Titles: – TitleFull: Glutathione s-transferase p1, maternal smoking, and asthma in children: a haplotype-based analysis. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Li YF – PersonEntity: Name: NameFull: Gauderman WJ – PersonEntity: Name: NameFull: Conti DV – PersonEntity: Name: NameFull: Lin PC – PersonEntity: Name: NameFull: Avol E – PersonEntity: Name: NameFull: Gilliland FD IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2008 Type: published Y: 2008 Identifiers: – Type: issn-print Value: 00916765 Numbering: – Type: volume Value: 116 – Type: issue Value: 3 Titles: – TitleFull: Environmental Health Perspectives Type: main |
| ResultId | 1 |
