Age- and concentration-dependent elimination half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso children.
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| Title: | Age- and concentration-dependent elimination half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso children. |
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| Authors: | Kerger BD (AUTHOR), Leung HW (AUTHOR), Scott P (AUTHOR), Paustenbach DJ (AUTHOR), Needham LL (AUTHOR), Patterson DG Jr (AUTHOR), Gerthoux PM (AUTHOR), Mocarelli P (AUTHOR) |
| Source: | Environmental Health Perspectives. Oct2006, Vol. 114 Issue 10, p1596-1602. 7p. |
| Abstract: | Objective: Pharmacokinetic and statistical analyses are reported to elucidate key variables affecting 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in children and adolescents. Design: We used blood concentrations to calculate TCDD elimination half-life. Variables examined by statistical analysis include age, latency from exposure, sex, TCDD concentration and quantity in the body, severity of chloracne response, body mass index, and body fat mass. Participants: Blood was collected from 1976 to 1993 from residents of Seveso, Italy, who were < 18 years of age at the time of a nearby trichlorophenol reactor explosion in July 1976. Results: TCDD half-life in persons < 18 years of age averaged 1.6 years while those >/=18 years of age averaged 3.2 years. Half-life is strongly associated with age, showing a cohort average increase of 0.12 year half-life per year of age or time since exposure. A significant concentration-dependency is also identified, showing shorter half-lives for TCDD concentrations > 400 ppt for children < 12 years of age and 700 ppt when including adults. Moderate correlations are also observed between half-life and body mass index, body fat mass, TCDD mass, and chloracne response. Conclusions: Children and adolescents have shorter TCDD half-lives and a slower rate of increase in half-life than adults, and this effect is augmented at higher body burdens.RelevanceModeling of TCDD blood concentrations or body burden in humans should take into account the markedly shorter elimination half-life observed in children and adolescents and concentration-dependent effects observed in persons > 400-700 ppt. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| URL: | 22882767 |
| Database: | GreenFILE |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 105949599 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Age- and concentration-dependent elimination half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso children. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Kerger+BD%22">Kerger BD</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Leung+HW%22">Leung HW</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Scott+P%22">Scott P</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Paustenbach+DJ%22">Paustenbach DJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Needham+LL%22">Needham LL</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Patterson+DG+Jr%22">Patterson DG Jr</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gerthoux+PM%22">Gerthoux PM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mocarelli+P%22">Mocarelli P</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Oct2006, Vol. 114 Issue 10, p1596-1602. 7p. – Name: Abstract Label: Abstract Group: Ab Data: Objective: Pharmacokinetic and statistical analyses are reported to elucidate key variables affecting 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) elimination in children and adolescents. Design: We used blood concentrations to calculate TCDD elimination half-life. Variables examined by statistical analysis include age, latency from exposure, sex, TCDD concentration and quantity in the body, severity of chloracne response, body mass index, and body fat mass. Participants: Blood was collected from 1976 to 1993 from residents of Seveso, Italy, who were < 18 years of age at the time of a nearby trichlorophenol reactor explosion in July 1976. Results: TCDD half-life in persons < 18 years of age averaged 1.6 years while those >/=18 years of age averaged 3.2 years. Half-life is strongly associated with age, showing a cohort average increase of 0.12 year half-life per year of age or time since exposure. A significant concentration-dependency is also identified, showing shorter half-lives for TCDD concentrations > 400 ppt for children < 12 years of age and 700 ppt when including adults. Moderate correlations are also observed between half-life and body mass index, body fat mass, TCDD mass, and chloracne response. Conclusions: Children and adolescents have shorter TCDD half-lives and a slower rate of increase in half-life than adults, and this effect is augmented at higher body burdens.RelevanceModeling of TCDD blood concentrations or body burden in humans should take into account the markedly shorter elimination half-life observed in children and adolescents and concentration-dependent effects observed in persons > 400-700 ppt. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) – Name: URL Label: URL Group: URL Data: <link linkTarget="URL" linkTerm="22882767" linkWindow="_blank">22882767</link> |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1289/ehp.8884 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 7 StartPage: 1596 Titles: – TitleFull: Age- and concentration-dependent elimination half-life of 2,3,7,8-tetrachlorodibenzo-p-dioxin in Seveso children. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Kerger BD – PersonEntity: Name: NameFull: Leung HW – PersonEntity: Name: NameFull: Scott P – PersonEntity: Name: NameFull: Paustenbach DJ – PersonEntity: Name: NameFull: Needham LL – PersonEntity: Name: NameFull: Patterson DG Jr – PersonEntity: Name: NameFull: Gerthoux PM – PersonEntity: Name: NameFull: Mocarelli P IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 10 Text: Oct2006 Type: published Y: 2006 Identifiers: – Type: issn-print Value: 00916765 Numbering: – Type: volume Value: 114 – Type: issue Value: 10 Titles: – TitleFull: Environmental Health Perspectives Type: main |
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