Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1)
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| Title: | Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1) |
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| Authors: | Nielsen SS (AUTHOR), Mueller BA (AUTHOR), De Roos AJ (AUTHOR), Viernes HA (AUTHOR), Farin FM (AUTHOR), Checkoway H (AUTHOR) |
| Source: | Environmental Health Perspectives. Jul2005, Vol. 113 Issue 7, p909-913. 5p. |
| Abstract: | Prior research suggests that childhood brain tumors (CBTs) may be associated with exposure to pesticides. Organophosphorus insecticides (OPs) target the developing nervous system, and until recently, the most common residential insecticides were chlorpyrifos and diazinon, two OPs metabolized in the body through the cytochrome P450/paraoxonase 1 (PON1) pathway. To investigate whether two common PON1 polymorphisms, C-108T and Q192R, are associated with CBT occurrence, we conducted a population-based study of 66 cases and 236 controls using DNA from neonatal screening archive specimens in Washington State, linked to interview data. The risk of CBT was nonsignificantly increased in relation to the inefficient PON1 promoter allele [per PON1(-108T) allele, relative to PON1(-108CC): odds ratio (OR) = 1.4; 95% confidence interval (CI), 1.0-2.2; p-value for trend = 0.07]. Notably, this association was strongest and statistically significant among children whose mothers reported chemical treatment of the home for pests during pregnancy or childhood (per PON1(-108T) allele: among exposed, OR = 2.6; 95% CI, 1.2-5.5; among unexposed, OR = 0.9; 95% CI, 0.5-1.6) and for primitive neuroectodermal tumors (per PON1(-108T) allele: OR = 2.4; 95% CI, 1.1-5.4). The Q192R polymorphism, which alters the structure of PON1 and influences enzyme activity in a substrate-dependent manner, was not associated with CBT risk, nor was the PON1(C-108T/Q192R) haplotype. These results are consistent with an inverse association between PON1 levels and CBT occurrence, perhaps because of PON1's ability to detoxify OPs common in children's environments. Larger studies that measure plasma PON1 levels and incorporate more accurate estimates of pesticide exposure will be required to confirm these observations. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| URL: | 17935142 |
| Database: | GreenFILE |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 106332367 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1) – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Nielsen+SS%22">Nielsen SS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mueller+BA%22">Mueller BA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Roos+AJ%22">De Roos AJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Viernes+HA%22">Viernes HA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Farin+FM%22">Farin FM</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Checkoway+H%22">Checkoway H</searchLink> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Jul2005, Vol. 113 Issue 7, p909-913. 5p. – Name: Abstract Label: Abstract Group: Ab Data: Prior research suggests that childhood brain tumors (CBTs) may be associated with exposure to pesticides. Organophosphorus insecticides (OPs) target the developing nervous system, and until recently, the most common residential insecticides were chlorpyrifos and diazinon, two OPs metabolized in the body through the cytochrome P450/paraoxonase 1 (PON1) pathway. To investigate whether two common PON1 polymorphisms, C-108T and Q192R, are associated with CBT occurrence, we conducted a population-based study of 66 cases and 236 controls using DNA from neonatal screening archive specimens in Washington State, linked to interview data. The risk of CBT was nonsignificantly increased in relation to the inefficient PON1 promoter allele [per PON1(-108T) allele, relative to PON1(-108CC): odds ratio (OR) = 1.4; 95% confidence interval (CI), 1.0-2.2; p-value for trend = 0.07]. Notably, this association was strongest and statistically significant among children whose mothers reported chemical treatment of the home for pests during pregnancy or childhood (per PON1(-108T) allele: among exposed, OR = 2.6; 95% CI, 1.2-5.5; among unexposed, OR = 0.9; 95% CI, 0.5-1.6) and for primitive neuroectodermal tumors (per PON1(-108T) allele: OR = 2.4; 95% CI, 1.1-5.4). The Q192R polymorphism, which alters the structure of PON1 and influences enzyme activity in a substrate-dependent manner, was not associated with CBT risk, nor was the PON1(C-108T/Q192R) haplotype. These results are consistent with an inverse association between PON1 levels and CBT occurrence, perhaps because of PON1's ability to detoxify OPs common in children's environments. Larger studies that measure plasma PON1 levels and incorporate more accurate estimates of pesticide exposure will be required to confirm these observations. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) – Name: URL Label: URL Group: URL Data: <link linkTarget="URL" linkTerm="17935142" linkWindow="_blank">17935142</link> |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1289/ehp.7680 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 5 StartPage: 909 Titles: – TitleFull: Risk of brain tumors in children and susceptibility to organophosphorus insecticides: the potential role of paraoxonase (PON1) Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Nielsen SS – PersonEntity: Name: NameFull: Mueller BA – PersonEntity: Name: NameFull: De Roos AJ – PersonEntity: Name: NameFull: Viernes HA – PersonEntity: Name: NameFull: Farin FM – PersonEntity: Name: NameFull: Checkoway H IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2005 Type: published Y: 2005 Identifiers: – Type: issn-print Value: 00916765 Numbering: – Type: volume Value: 113 – Type: issue Value: 7 Titles: – TitleFull: Environmental Health Perspectives Type: main |
| ResultId | 1 |
