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Phenolic acid protects of renal damage induced by ochratoxin A in a 28-days-oral treatment in rats.

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Title: Phenolic acid protects of renal damage induced by ochratoxin A in a 28-days-oral treatment in rats.
Authors: Cariddi, L.N.1,2 ncariddi@yahoo.com.ar, Escobar, F.M.1,2, Sabini, M.C.1,2, Campra, N.A.1, Bagnis, G.3, Decote-Ricardo, D.4, Freire-de-Lima, C.G.4, Mañas, F.5, Sabini, L.I.1, Dalcero, A.M.1,2
Source: Environmental Toxicology & Pharmacology. Apr2016, Vol. 43, p105-111. 7p.
Subject Terms: *Phenolic acids, Ochratoxins, Oral drug administration, Kidney disease treatments, Laboratory rats
Abstract: The present study aimed to characterize the chlorogenic acid (ChlA) capacity to reverse the toxic effects induced by ochratoxin A (OTA) in a subacute toxicity test in rats. Male Wistar rats were fed orally by gavage for 28 days with OTA (0.4 mg/kg bw/day), ChlA (5 mg/kg bw/day) or the combination OTA (0.4 mg/kg bw/day) + ChlA (5 mg/kg bw/day). No deaths, no decrease in feed intake or body weight in any experimental group were recorded. The negative control group and the animals treated with ChlA alone showed no changes in any parameters evaluated. In OTA-treated group significant changes such as decrease in urine volume, proteinuria, occult blood, increase in serum creatinine values; decrease in absolute and relative kidney weight and characteristics histopathological lesions that indicated kidney damage were observed. However, limited effect on oxidative stress parameters were detected in kidneys of OTA-treated group. Animals treated with the combination OTA + ChlA were showed as negative control group in the evaluation of several parameters of toxicity. In conclusion, ChlA, at given concentration, improved biochemical parameters altered in urine and serum and pathological damages in kidneys induced by OTA exposure, showing a good protective activity, but not by an apparent antioxidant mechanism. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Toxicology & Pharmacology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Phenolic acid protects of renal damage induced by ochratoxin A in a 28-days-oral treatment in rats.
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  Data: <searchLink fieldCode="AR" term="%22Cariddi%2C+L%2EN%2E%22">Cariddi, L.N.</searchLink><relatesTo>1,2</relatesTo><i> ncariddi@yahoo.com.ar</i><br /><searchLink fieldCode="AR" term="%22Escobar%2C+F%2EM%2E%22">Escobar, F.M.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sabini%2C+M%2EC%2E%22">Sabini, M.C.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Campra%2C+N%2EA%2E%22">Campra, N.A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bagnis%2C+G%2E%22">Bagnis, G.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Decote-Ricardo%2C+D%2E%22">Decote-Ricardo, D.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Freire-de-Lima%2C+C%2EG%2E%22">Freire-de-Lima, C.G.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Mañas%2C+F%2E%22">Mañas, F.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Sabini%2C+L%2EI%2E%22">Sabini, L.I.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Dalcero%2C+A%2EM%2E%22">Dalcero, A.M.</searchLink><relatesTo>1,2</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Toxicology+%26+Pharmacology%22">Environmental Toxicology & Pharmacology</searchLink>. Apr2016, Vol. 43, p105-111. 7p.
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  Data: *<searchLink fieldCode="DE" term="%22Phenolic+acids%22">Phenolic acids</searchLink><br /><searchLink fieldCode="DE" term="%22Ochratoxins%22">Ochratoxins</searchLink><br /><searchLink fieldCode="DE" term="%22Oral+drug+administration%22">Oral drug administration</searchLink><br /><searchLink fieldCode="DE" term="%22Kidney+disease+treatments%22">Kidney disease treatments</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink>
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  Data: The present study aimed to characterize the chlorogenic acid (ChlA) capacity to reverse the toxic effects induced by ochratoxin A (OTA) in a subacute toxicity test in rats. Male Wistar rats were fed orally by gavage for 28 days with OTA (0.4 mg/kg bw/day), ChlA (5 mg/kg bw/day) or the combination OTA (0.4 mg/kg bw/day) + ChlA (5 mg/kg bw/day). No deaths, no decrease in feed intake or body weight in any experimental group were recorded. The negative control group and the animals treated with ChlA alone showed no changes in any parameters evaluated. In OTA-treated group significant changes such as decrease in urine volume, proteinuria, occult blood, increase in serum creatinine values; decrease in absolute and relative kidney weight and characteristics histopathological lesions that indicated kidney damage were observed. However, limited effect on oxidative stress parameters were detected in kidneys of OTA-treated group. Animals treated with the combination OTA + ChlA were showed as negative control group in the evaluation of several parameters of toxicity. In conclusion, ChlA, at given concentration, improved biochemical parameters altered in urine and serum and pathological damages in kidneys induced by OTA exposure, showing a good protective activity, but not by an apparent antioxidant mechanism. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Environmental Toxicology & Pharmacology is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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              Text: Apr2016
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