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Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study.

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Title: Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study.
Authors: Mee-Ri Lee1, Youn-Hee Lim2,3, Bo-Eun Lee4, Yun-Chul Hong1,2,3 ychong1@snu.ac.kr, Lee, Mee-Ri1 (AUTHOR), Lim, Youn-Hee2,3 (AUTHOR), Lee, Bo-Eun4 (AUTHOR), Hong, Yun-Chul1,2,3 (AUTHOR)
Source: Environmental Health: A Global Access Science Source. 3/4/2017, Vol. 16, p1-8. 8p. 4 Charts, 1 Graph.
Subject Terms: *Mercury in the body, *Mercury (Element), *Pollutants, Liver function tests, Health of older people, Liver enzymes, Alcohol drinking, Confidence intervals, Glutamyl-tRNA synthetase, Oxidative stress, Aspartate aminotransferase, Liver diseases, Obesity, Malondialdehyde, Alanine aminotransferase, Lifestyles, Gamma-glutamyltransferase
Geographic Terms: South Korea
Abstract: Background: Mercury is a toxic heavy metal and is known to affect many diseases. However, few studies have examined the effects of mercury exposure on liver function in the general population. We examined the association between blood mercury concentrations and liver enzyme levels in the elderly.Methods: We included 560 elderly participants (60 years or older) who were recruited from 2008 to 2010 and followed up to 2014. Subjects visited a community welfare center and underwent a medical examination and measurement of mercury levels up to five times. Analyses using generalized estimating equations model were performed after adjusting for age, sex, education, overweight, alcohol consumption, smoking, regular exercise, high-density lipoproteins cholesterol, and total calorie intake. Additionally, we estimated interaction effects of alcohol consumption with mercury and mediation effect of oxidative stress in the relationship between mercury levels and liver function.Results: The geometric mean (95% confidence interval (CI)) of blood mercury concentrations was 2.81 μg/L (2.73, 2.89). Significant relationships were observed between blood mercury concentrations and the level of liver enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transferase (GGT), after adjusting for potential confounders (P < 0.05). The odds ratios of having abnormal ALT levels were statistically significant in the highest mercury quartile compared to those with the lowest quartile. Particularly, regular alcohol drinkers showed greater effect estimates of mercury on the liver function than non-drinkers groups. There was no mediation effect of oxidative stress in the relationship between blood mercury concentrations and liver function.Conclusions: Our results suggest that blood mercury levels are associated with elevated liver enzymes and interact with alcohol consumption for the association in the elderly. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study.
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  Data: &lt;bold&gt;Background: &lt;/bold&gt;Mercury is a toxic heavy metal and is known to affect many diseases. However, few studies have examined the effects of mercury exposure on liver function in the general population. We examined the association between blood mercury concentrations and liver enzyme levels in the elderly.&lt;bold&gt;Methods: &lt;/bold&gt;We included 560 elderly participants (60&#160;years or older) who were recruited from 2008 to 2010 and followed up to 2014. Subjects visited a community welfare center and underwent a medical examination and measurement of mercury levels up to five times. Analyses using generalized estimating equations model were performed after adjusting for age, sex, education, overweight, alcohol consumption, smoking, regular exercise, high-density lipoproteins cholesterol, and total calorie intake. Additionally, we estimated interaction effects of alcohol consumption with mercury and mediation effect of oxidative stress in the relationship between mercury levels and liver function.&lt;bold&gt;Results: &lt;/bold&gt;The geometric mean (95% confidence interval (CI)) of blood mercury concentrations was 2.81&#160;μg/L (2.73, 2.89). Significant relationships were observed between blood mercury concentrations and the level of liver enzymes, including aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma glutamyl transferase (GGT), after adjusting for potential confounders (P &lt; 0.05). The odds ratios of having abnormal ALT levels were statistically significant in the highest mercury quartile compared to those with the lowest quartile. Particularly, regular alcohol drinkers showed greater effect estimates of mercury on the liver function than non-drinkers groups. There was no mediation effect of oxidative stress in the relationship between blood mercury concentrations and liver function.&lt;bold&gt;Conclusions: &lt;/bold&gt;Our results suggest that blood mercury levels are associated with elevated liver enzymes and interact with alcohol consumption for the association in the elderly. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of Environmental Health: A Global Access Science Source is the property of BioMed Central and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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        Value: 10.1186/s12940-017-0228-2
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      – Code: eng
        Text: English
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      – SubjectFull: Mercury in the body
        Type: general
      – SubjectFull: Mercury (Element)
        Type: general
      – SubjectFull: Pollutants
        Type: general
      – SubjectFull: Liver function tests
        Type: general
      – SubjectFull: Health of older people
        Type: general
      – SubjectFull: Liver enzymes
        Type: general
      – SubjectFull: Alcohol drinking
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      – SubjectFull: Confidence intervals
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      – SubjectFull: Glutamyl-tRNA synthetase
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      – SubjectFull: Oxidative stress
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      – SubjectFull: Aspartate aminotransferase
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      – SubjectFull: Liver diseases
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      – SubjectFull: Obesity
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      – SubjectFull: Malondialdehyde
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      – SubjectFull: Alanine aminotransferase
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      – SubjectFull: Lifestyles
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      – SubjectFull: Gamma-glutamyltransferase
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      – SubjectFull: South Korea
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      – TitleFull: Blood mercury concentrations are associated with decline in liver function in an elderly population: a panel study.
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              Text: 3/4/2017
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