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First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls.

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Title: First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls.
Authors: Barrett, Emily S.1,2 Emily.barrett@eohsi.rutgers.edu, Sathyanarayana, Sheela3,4, Mbowe, Omar5, Thurston, Sally W.5, Redmon, J. Bruce6, Nguyen, Ruby H. N.7, Swan, Shanna H.8
Source: Environmental Health Perspectives. Jul2017, Vol. 125 Issue 7, p1-8. 8p. 1 Diagram, 2 Charts.
Subject Terms: *Plastics, Anus, Female reproductive organs, Anthropometry, Hormone antagonists, Human reproduction, Longitudinal method, Polymethylmethacrylate, First trimester of pregnancy, Research funding, Statistics, Anatomy
Abstract: INTRODUCTION: Evidence from animal models suggests that prenatal exposure to bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, is associated with adverse reproductive outcomes in females. Exposure during early gestation, a critical period for reproductive development, is of particular concern. Anogenital distance (AGD) is a sensitive biomarker of the fetal hormonal milieu and a measure of reproductive toxicity in animal models. In some studies, the daughters of BPA-exposed dams have shorter AGD than controls. Here, we investigate this relationship in humans. METHODS: BPA was assayed in first-trimester urine samples from 385 participants who delivered infant girls in a multicenter pregnancy cohort study. After birth, daughters underwent exams that included two measures of AGD (AGD-AC: distance from center of anus to clitoris; AGD-AF: distance from center of anus to fourchette). We fit linear regression models to examine the association between specific gravity-adjusted (SPG-adj) maternal BPA concentrations and infant AGD, adjusting for covariates. RESULTS: BPA was detectable in 94% of women. In covariate-adjusted models fit on 381 eligible subjects, the natural logarithm of SpG-adj maternal BPA concentration was inversely associated with infant AGD-AC [β= -0:56, 95% confidence interval (CI): -0:97, -0:15]. We observed no association between maternal BPA and infant AGD-AF. CONCLUSION: BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls.
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  Data: <searchLink fieldCode="AR" term="%22Barrett%2C+Emily+S%2E%22">Barrett, Emily S.</searchLink><relatesTo>1,2</relatesTo><i> Emily.barrett@eohsi.rutgers.edu</i><br /><searchLink fieldCode="AR" term="%22Sathyanarayana%2C+Sheela%22">Sathyanarayana, Sheela</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Mbowe%2C+Omar%22">Mbowe, Omar</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Thurston%2C+Sally+W%2E%22">Thurston, Sally W.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Redmon%2C+J%2E+Bruce%22">Redmon, J. Bruce</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Nguyen%2C+Ruby+H%2E+N%2E%22">Nguyen, Ruby H. N.</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Swan%2C+Shanna+H%2E%22">Swan, Shanna H.</searchLink><relatesTo>8</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Jul2017, Vol. 125 Issue 7, p1-8. 8p. 1 Diagram, 2 Charts.
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  Data: *<searchLink fieldCode="DE" term="%22Plastics%22">Plastics</searchLink><br /><searchLink fieldCode="DE" term="%22Anus%22">Anus</searchLink><br /><searchLink fieldCode="DE" term="%22Female+reproductive+organs%22">Female reproductive organs</searchLink><br /><searchLink fieldCode="DE" term="%22Anthropometry%22">Anthropometry</searchLink><br /><searchLink fieldCode="DE" term="%22Hormone+antagonists%22">Hormone antagonists</searchLink><br /><searchLink fieldCode="DE" term="%22Human+reproduction%22">Human reproduction</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Polymethylmethacrylate%22">Polymethylmethacrylate</searchLink><br /><searchLink fieldCode="DE" term="%22First+trimester+of+pregnancy%22">First trimester of pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Anatomy%22">Anatomy</searchLink>
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  Label: Abstract
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  Data: INTRODUCTION: Evidence from animal models suggests that prenatal exposure to bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical, is associated with adverse reproductive outcomes in females. Exposure during early gestation, a critical period for reproductive development, is of particular concern. Anogenital distance (AGD) is a sensitive biomarker of the fetal hormonal milieu and a measure of reproductive toxicity in animal models. In some studies, the daughters of BPA-exposed dams have shorter AGD than controls. Here, we investigate this relationship in humans. METHODS: BPA was assayed in first-trimester urine samples from 385 participants who delivered infant girls in a multicenter pregnancy cohort study. After birth, daughters underwent exams that included two measures of AGD (AGD-AC: distance from center of anus to clitoris; AGD-AF: distance from center of anus to fourchette). We fit linear regression models to examine the association between specific gravity-adjusted (SPG-adj) maternal BPA concentrations and infant AGD, adjusting for covariates. RESULTS: BPA was detectable in 94% of women. In covariate-adjusted models fit on 381 eligible subjects, the natural logarithm of SpG-adj maternal BPA concentration was inversely associated with infant AGD-AC [β= -0:56, 95% confidence interval (CI): -0:97, -0:15]. We observed no association between maternal BPA and infant AGD-AF. CONCLUSION: BPA may have toxic effects on the female reproductive system in humans, as it does in animal models. Higher first-trimester BPA exposure was associated with significantly shorter AGD in daughters, suggesting that BPA may alter the hormonal environment of the female fetus. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1289/EHP875
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        Text: English
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        PageCount: 8
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    Subjects:
      – SubjectFull: Plastics
        Type: general
      – SubjectFull: Anus
        Type: general
      – SubjectFull: Female reproductive organs
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      – SubjectFull: Anthropometry
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      – SubjectFull: Hormone antagonists
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      – SubjectFull: Polymethylmethacrylate
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      – SubjectFull: First trimester of pregnancy
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      – TitleFull: First-Trimester Urinary Bisphenol A Concentration in Relation to Anogenital Distance, an Androgen-Sensitive Measure of Reproductive Development, in Infant Girls.
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