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Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis.

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Title: Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis.
Authors: D'Souza, Jennifer C.1, Kawut, Steven M.2, Elkayam, Laura R.1, Sheppard, Lianne3,4, Thorne, Peter S.5, Jacobs Jr., David R.6, Bluemke, David A.7, Lima, Joao A. C.8, Kaufman, Joel D.3,9,10, Larson, Timothy V.3,11, Adar, Sara D.1 sadar@umich.edu
Source: Environmental Health Perspectives. Jul2017, Vol. 125 Issue 7, p1-8. 8p. 2 Charts, 1 Graph.
Subject Terms: *Copper, *Phosphorus, *Smoking, *Zinc, *Environmental exposure, *Particulate matter, Heart ventricle diseases, Confidence intervals, Disease susceptibility, Pulmonary emphysema, Endotoxins, Right heart ventricle, Longitudinal method, Magnetic resonance imaging, Medical cooperation, Multivariate analysis, Probability theory, Regression analysis, Research, Research funding, Silicon, Cross-sectional method, Data analysis software, Descriptive statistics, Stroke volume (Cardiac output), Ventricular ejection fraction
Geographic Terms: Illinois, Minnesota, North Carolina
Abstract: BACKGROUND: Coarse particulate matter (PM10-2.5) is primarily mechanically generated and includes crustal material, brake and tire wear, and biological particles. PM10-2.5 is associated with pulmonary disease, which can lead to right ventricular (RV) dysfunction. Although RV characteristics have been associated with combustion-related pollutants, relationships with PM10-2.5 remain unknown. OBJECTIVES: To quantify cross-sectional associations between RV dysfunction and PM10-2.5 mass and components among older adults and susceptible populations. METHODS: We used baseline cardiac magnetic resonance images from 1,490 participants (45-84 y old) from the Multi-Ethnic Study of Atherosclerosis and assigned 5-y residential concentrations of PM10-2.5 mass, copper, zinc, phosphorus, silicon, and endotoxin, using land-use regression models. We quantified associations with RV mass, end-diastolic volume, and ejection fraction after control for risk factors and copollutants using linear regression. We further examined personal susceptibility. RESULTS: We found positive associations of RV mass and, to a lesser extent, end diastolic volume with PM10-2.5 mass among susceptible populations including smokers and persons with emphysema. After adjustment for copollutants, an interquartile range increase in PM10-2.5 mass (2:2 μg/m³) was associated with 0:5 g (95% CI: 0.0, 1.0), 0:9 g (95% CI: 0.1, 1.7), and 1:4 g (95% CI: 0.4, 2.5) larger RV mass among former smokers, current smokers, and persons with emphysema, respectively. No associations were found with healthy individuals or with ejection fraction. CONCLUSIONS: Alterations to RV structure may represent a mechanism by which long-term PM10-2.5 exposure increases risks for adverse respiratory and cardiovascular outcomes, especially among certain susceptible populations. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Ambient Coarse Particulate Matter and the Right Ventricle: The Multi-Ethnic Study of Atherosclerosis.
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  Data: <searchLink fieldCode="AR" term="%22D'Souza%2C+Jennifer+C%2E%22">D'Souza, Jennifer C.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kawut%2C+Steven+M%2E%22">Kawut, Steven M.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Elkayam%2C+Laura+R%2E%22">Elkayam, Laura R.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sheppard%2C+Lianne%22">Sheppard, Lianne</searchLink><relatesTo>3,4</relatesTo><br /><searchLink fieldCode="AR" term="%22Thorne%2C+Peter+S%2E%22">Thorne, Peter S.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Jacobs+Jr%2E%2C+David+R%2E%22">Jacobs Jr., David R.</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Bluemke%2C+David+A%2E%22">Bluemke, David A.</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Lima%2C+Joao+A%2E+C%2E%22">Lima, Joao A. C.</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Kaufman%2C+Joel+D%2E%22">Kaufman, Joel D.</searchLink><relatesTo>3,9,10</relatesTo><br /><searchLink fieldCode="AR" term="%22Larson%2C+Timothy+V%2E%22">Larson, Timothy V.</searchLink><relatesTo>3,11</relatesTo><br /><searchLink fieldCode="AR" term="%22Adar%2C+Sara+D%2E%22">Adar, Sara D.</searchLink><relatesTo>1</relatesTo><i> sadar@umich.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Jul2017, Vol. 125 Issue 7, p1-8. 8p. 2 Charts, 1 Graph.
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  Data: *<searchLink fieldCode="DE" term="%22Copper%22">Copper</searchLink><br />*<searchLink fieldCode="DE" term="%22Phosphorus%22">Phosphorus</searchLink><br />*<searchLink fieldCode="DE" term="%22Smoking%22">Smoking</searchLink><br />*<searchLink fieldCode="DE" term="%22Zinc%22">Zinc</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br />*<searchLink fieldCode="DE" term="%22Particulate+matter%22">Particulate matter</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+ventricle+diseases%22">Heart ventricle diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+susceptibility%22">Disease susceptibility</searchLink><br /><searchLink fieldCode="DE" term="%22Pulmonary+emphysema%22">Pulmonary emphysema</searchLink><br /><searchLink fieldCode="DE" term="%22Endotoxins%22">Endotoxins</searchLink><br /><searchLink fieldCode="DE" term="%22Right+heart+ventricle%22">Right heart ventricle</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+cooperation%22">Medical cooperation</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Probability+theory%22">Probability theory</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Silicon%22">Silicon</searchLink><br /><searchLink fieldCode="DE" term="%22Cross-sectional+method%22">Cross-sectional method</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Stroke+volume+%28Cardiac+output%29%22">Stroke volume (Cardiac output)</searchLink><br /><searchLink fieldCode="DE" term="%22Ventricular+ejection+fraction%22">Ventricular ejection fraction</searchLink>
– Name: SubjectGeographic
  Label: Geographic Terms
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Illinois%22">Illinois</searchLink><br /><searchLink fieldCode="DE" term="%22Minnesota%22">Minnesota</searchLink><br /><searchLink fieldCode="DE" term="%22North+Carolina%22">North Carolina</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND: Coarse particulate matter (PM10-2.5) is primarily mechanically generated and includes crustal material, brake and tire wear, and biological particles. PM10-2.5 is associated with pulmonary disease, which can lead to right ventricular (RV) dysfunction. Although RV characteristics have been associated with combustion-related pollutants, relationships with PM10-2.5 remain unknown. OBJECTIVES: To quantify cross-sectional associations between RV dysfunction and PM10-2.5 mass and components among older adults and susceptible populations. METHODS: We used baseline cardiac magnetic resonance images from 1,490 participants (45-84 y old) from the Multi-Ethnic Study of Atherosclerosis and assigned 5-y residential concentrations of PM10-2.5 mass, copper, zinc, phosphorus, silicon, and endotoxin, using land-use regression models. We quantified associations with RV mass, end-diastolic volume, and ejection fraction after control for risk factors and copollutants using linear regression. We further examined personal susceptibility. RESULTS: We found positive associations of RV mass and, to a lesser extent, end diastolic volume with PM10-2.5 mass among susceptible populations including smokers and persons with emphysema. After adjustment for copollutants, an interquartile range increase in PM10-2.5 mass (2:2 μg/m³) was associated with 0:5 g (95% CI: 0.0, 1.0), 0:9 g (95% CI: 0.1, 1.7), and 1:4 g (95% CI: 0.4, 2.5) larger RV mass among former smokers, current smokers, and persons with emphysema, respectively. No associations were found with healthy individuals or with ejection fraction. CONCLUSIONS: Alterations to RV structure may represent a mechanism by which long-term PM10-2.5 exposure increases risks for adverse respiratory and cardiovascular outcomes, especially among certain susceptible populations. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1289/EHP658
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 1
    Subjects:
      – SubjectFull: Copper
        Type: general
      – SubjectFull: Phosphorus
        Type: general
      – SubjectFull: Smoking
        Type: general
      – SubjectFull: Zinc
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      – SubjectFull: Environmental exposure
        Type: general
      – SubjectFull: Particulate matter
        Type: general
      – SubjectFull: Heart ventricle diseases
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Disease susceptibility
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      – SubjectFull: Pulmonary emphysema
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      – SubjectFull: Endotoxins
        Type: general
      – SubjectFull: Right heart ventricle
        Type: general
      – SubjectFull: Longitudinal method
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      – SubjectFull: Magnetic resonance imaging
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      – SubjectFull: Medical cooperation
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      – SubjectFull: Data analysis software
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      – SubjectFull: Stroke volume (Cardiac output)
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      – SubjectFull: Ventricular ejection fraction
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      – SubjectFull: Illinois
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      – SubjectFull: Minnesota
        Type: general
      – SubjectFull: North Carolina
        Type: general
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