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Triclosan affects axon formation in the neural development stages of zebrafish embryos (Danio rerio).

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Title: Triclosan affects axon formation in the neural development stages of zebrafish embryos (Danio rerio).
Authors: Kim, Jin1, Oh, Hanseul1, Ryu, Bokyeong1, Kim, Ukjin1, Lee, Ji Min1, Jung, Cho-Rok2, Kim, C-yoon3 vivavets@gmail.com, Park, Jae-Hak1 pjhak@snu.ac.kr
Source: Environmental Pollution. May2018, Vol. 236, p304-312. 9p.
Subject Terms: *Antibiotics, Zebra danio, Triclosan, Drug side effects, Neural development, Neurotoxicology
Abstract: Triclosan (TCS) is an organic compound with a wide range of antibiotic activity and has been widely used in items ranging from hygiene products to cosmetics; however, recent studies suggest that it has several adverse effects. In particular, TCS can be passed to both fetus and infants, and while some evidence suggests in vitro neurotoxicity, there are currently few studies concerning the mechanisms of TCS-induced developmental neurotoxicity. Therefore, this study aimed to clarify the effect of TCS on neural development using zebrafish models, by analyzing the morphological changes, the alterations observed in fluorescence using HuC-GFP and Olig2-dsRED transgenic zebrafish models, and neurodevelopmental gene expression. TCS exposure decreased the body length, head size, and eye size in a concentration-dependent manner in zebrafish embryos. It increased apoptosis in the central nervous system (CNS) and particularly affected the structure of the CNS, resulting in decreased synaptic density and shortened axon length. In addition, it significantly up-regulated the expression of genes related to axon extension and synapse formation such as α1-Tubulin and Gap43 , while decreasing Gfap and Mbp related to axon guidance, myelination and maintenance. Collectively, these changes indicate that exposure to TCS during neurodevelopment, especially during axonogenesis, is toxic. This is the first study to demonstrate the toxicity of TCS during neurogenesis, and suggests a possible mechanism underlying the neurotoxic effects of TCS in developing vertebrates. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Pollution is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Triclosan affects axon formation in the neural development stages of zebrafish embryos (Danio rerio).
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  Data: <searchLink fieldCode="AR" term="%22Kim%2C+Jin%22">Kim, Jin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Oh%2C+Hanseul%22">Oh, Hanseul</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ryu%2C+Bokyeong%22">Ryu, Bokyeong</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Ukjin%22">Kim, Ukjin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Ji+Min%22">Lee, Ji Min</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Jung%2C+Cho-Rok%22">Jung, Cho-Rok</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+C-yoon%22">Kim, C-yoon</searchLink><relatesTo>3</relatesTo><i> vivavets@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Park%2C+Jae-Hak%22">Park, Jae-Hak</searchLink><relatesTo>1</relatesTo><i> pjhak@snu.ac.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Pollution%22">Environmental Pollution</searchLink>. May2018, Vol. 236, p304-312. 9p.
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  Data: *<searchLink fieldCode="DE" term="%22Antibiotics%22">Antibiotics</searchLink><br /><searchLink fieldCode="DE" term="%22Zebra+danio%22">Zebra danio</searchLink><br /><searchLink fieldCode="DE" term="%22Triclosan%22">Triclosan</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+side+effects%22">Drug side effects</searchLink><br /><searchLink fieldCode="DE" term="%22Neural+development%22">Neural development</searchLink><br /><searchLink fieldCode="DE" term="%22Neurotoxicology%22">Neurotoxicology</searchLink>
– Name: Abstract
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  Data: Triclosan (TCS) is an organic compound with a wide range of antibiotic activity and has been widely used in items ranging from hygiene products to cosmetics; however, recent studies suggest that it has several adverse effects. In particular, TCS can be passed to both fetus and infants, and while some evidence suggests in vitro neurotoxicity, there are currently few studies concerning the mechanisms of TCS-induced developmental neurotoxicity. Therefore, this study aimed to clarify the effect of TCS on neural development using zebrafish models, by analyzing the morphological changes, the alterations observed in fluorescence using HuC-GFP and Olig2-dsRED transgenic zebrafish models, and neurodevelopmental gene expression. TCS exposure decreased the body length, head size, and eye size in a concentration-dependent manner in zebrafish embryos. It increased apoptosis in the central nervous system (CNS) and particularly affected the structure of the CNS, resulting in decreased synaptic density and shortened axon length. In addition, it significantly up-regulated the expression of genes related to axon extension and synapse formation such as α1-Tubulin and Gap43 , while decreasing Gfap and Mbp related to axon guidance, myelination and maintenance. Collectively, these changes indicate that exposure to TCS during neurodevelopment, especially during axonogenesis, is toxic. This is the first study to demonstrate the toxicity of TCS during neurogenesis, and suggests a possible mechanism underlying the neurotoxic effects of TCS in developing vertebrates. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Environmental Pollution is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.envpol.2017.12.110
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 9
        StartPage: 304
    Subjects:
      – SubjectFull: Antibiotics
        Type: general
      – SubjectFull: Zebra danio
        Type: general
      – SubjectFull: Triclosan
        Type: general
      – SubjectFull: Drug side effects
        Type: general
      – SubjectFull: Neural development
        Type: general
      – SubjectFull: Neurotoxicology
        Type: general
    Titles:
      – TitleFull: Triclosan affects axon formation in the neural development stages of zebrafish embryos (Danio rerio).
        Type: main
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            NameFull: Kim, Jin
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            NameFull: Oh, Hanseul
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            NameFull: Ryu, Bokyeong
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            NameFull: Kim, Ukjin
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            NameFull: Lee, Ji Min
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            NameFull: Jung, Cho-Rok
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            NameFull: Kim, C-yoon
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            – D: 01
              M: 05
              Text: May2018
              Type: published
              Y: 2018
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              Value: 02697491
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            – Type: volume
              Value: 236
          Titles:
            – TitleFull: Environmental Pollution
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