Polychlorinated Biphenyls (PCBs) Exert Thyroid Hormone-like Effects in the Fetal Rat Brain but Do Not Bind to Thyroid Hormone Receptors.
Saved in:
| Title: | Polychlorinated Biphenyls (PCBs) Exert Thyroid Hormone-like Effects in the Fetal Rat Brain but Do Not Bind to Thyroid Hormone Receptors. |
|---|---|
| Authors: | Gauger, Kelly J.1, Kato, Yoshihisa2, Haraguchi, Koichi3, Lehmler, Hans-Joachim4, Robertson, Larry W.4, Bansal, Ruby1, Zoeller, R. Thomas1 tzoeller@bio.umass.edu |
| Source: | Environmental Health Perspectives. Apr2004, Vol. 112 Issue 5, p516-523. 8p. |
| Subject Terms: | *Polychlorinated biphenyls, *Biphenyl compounds, *Pollutants, Neuropsychology, Thyroid hormones, Brain, Triiodothyronine, Genes |
| Abstract: | Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants routinely found in human and animal tissues. Developmental exposure to PCBs is associated with neuropsychologic deficits, which may be related to effects on thyroid hormone (TH) signaling in the developing brain. However, PCBs may interfere with TH signaling solely by reducing circulating levels of TH, or they may exert direct effects on TH receptors (TRs). Therefore, we tested whether maternal exposure to a commercial PCB mixture, Aroclor 1254 (A1254). exerts effects in the fetal brain b) one or both of these mechanisms. Dams were dosed daily with 0, 1, or 4 mg/kg A1254 from gestational day 6 (GD6) until they were sacrificed on GDI6. AI254 significantly reduced circulating levels of triiodothyronine (T3) and thyroxine (T1) fix pregnant rats but increased the expression of several Ill- responsive genes in fetal cortex, including neuroendocrine-specific protein A (NSP-A), RC3/neurogranin, and Oct-1. These findings are consistent with a direct action of PCBs on TRs. However, we did not identify parent PCB congeners or metabolites that bound to rat TRs isolated from hepatic nuclei. These findings indicate that PCBs can interfere with TH signaling in the fetal brain by direct actions on the fetus rather than by producing maternal hypothyroidism. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | GreenFILE |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: 8gh DbLabel: GreenFILE An: 13010779 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Polychlorinated Biphenyls (PCBs) Exert Thyroid Hormone-like Effects in the Fetal Rat Brain but Do Not Bind to Thyroid Hormone Receptors. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gauger%2C+Kelly+J%2E%22">Gauger, Kelly J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kato%2C+Yoshihisa%22">Kato, Yoshihisa</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Haraguchi%2C+Koichi%22">Haraguchi, Koichi</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Lehmler%2C+Hans-Joachim%22">Lehmler, Hans-Joachim</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Robertson%2C+Larry+W%2E%22">Robertson, Larry W.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Bansal%2C+Ruby%22">Bansal, Ruby</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Zoeller%2C+R%2E+Thomas%22">Zoeller, R. Thomas</searchLink><relatesTo>1</relatesTo><i> tzoeller@bio.umass.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Apr2004, Vol. 112 Issue 5, p516-523. 8p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Polychlorinated+biphenyls%22">Polychlorinated biphenyls</searchLink><br />*<searchLink fieldCode="DE" term="%22Biphenyl+compounds%22">Biphenyl compounds</searchLink><br />*<searchLink fieldCode="DE" term="%22Pollutants%22">Pollutants</searchLink><br /><searchLink fieldCode="DE" term="%22Neuropsychology%22">Neuropsychology</searchLink><br /><searchLink fieldCode="DE" term="%22Thyroid+hormones%22">Thyroid hormones</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Triiodothyronine%22">Triiodothyronine</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Polychlorinated biphenyls (PCBs) are ubiquitous environmental contaminants routinely found in human and animal tissues. Developmental exposure to PCBs is associated with neuropsychologic deficits, which may be related to effects on thyroid hormone (TH) signaling in the developing brain. However, PCBs may interfere with TH signaling solely by reducing circulating levels of TH, or they may exert direct effects on TH receptors (TRs). Therefore, we tested whether maternal exposure to a commercial PCB mixture, Aroclor 1254 (A1254). exerts effects in the fetal brain b) one or both of these mechanisms. Dams were dosed daily with 0, 1, or 4 mg/kg A1254 from gestational day 6 (GD6) until they were sacrificed on GDI6. AI254 significantly reduced circulating levels of triiodothyronine (T3) and thyroxine (T1) fix pregnant rats but increased the expression of several Ill- responsive genes in fetal cortex, including neuroendocrine-specific protein A (NSP-A), RC3/neurogranin, and Oct-1. These findings are consistent with a direct action of PCBs on TRs. However, we did not identify parent PCB congeners or metabolites that bound to rat TRs isolated from hepatic nuclei. These findings indicate that PCBs can interfere with TH signaling in the fetal brain by direct actions on the fetus rather than by producing maternal hypothyroidism. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=13010779 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1289/ehp.6672 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 516 Subjects: – SubjectFull: Polychlorinated biphenyls Type: general – SubjectFull: Biphenyl compounds Type: general – SubjectFull: Pollutants Type: general – SubjectFull: Neuropsychology Type: general – SubjectFull: Thyroid hormones Type: general – SubjectFull: Brain Type: general – SubjectFull: Triiodothyronine Type: general – SubjectFull: Genes Type: general Titles: – TitleFull: Polychlorinated Biphenyls (PCBs) Exert Thyroid Hormone-like Effects in the Fetal Rat Brain but Do Not Bind to Thyroid Hormone Receptors. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gauger, Kelly J. – PersonEntity: Name: NameFull: Kato, Yoshihisa – PersonEntity: Name: NameFull: Haraguchi, Koichi – PersonEntity: Name: NameFull: Lehmler, Hans-Joachim – PersonEntity: Name: NameFull: Robertson, Larry W. – PersonEntity: Name: NameFull: Bansal, Ruby – PersonEntity: Name: NameFull: Zoeller, R. Thomas IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2004 Type: published Y: 2004 Identifiers: – Type: issn-print Value: 00916765 Numbering: – Type: volume Value: 112 – Type: issue Value: 5 Titles: – TitleFull: Environmental Health Perspectives Type: main |
| ResultId | 1 |
