View in EDS PDF Full Text

Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study.

Saved in:
Bibliographic Details
Title: Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study.
Authors: Eze, Ikenna C.1,2 ikenna.eze@swisstph.ch, Jeong, Ayoung1,2, Schaffner, Emmanuel1,2, Rezwan, Faisal I.3,4, Ghantous, Akram5, Foraster, Maria1,2,6,7,8,9, Vienneau, Danielle1,2, Kronenberg, Florian10, Herceg, Zdenko5, Vineis, Paolo11,12, Brink, Mark13, Wunderli, Jean-Marc14, Schindler, Christian1,2, Cajochen, Christian15, Röösli, Martin1,2, Holloway, John W.3, Imboden, Medea1,2, Probst-Hensch1, Nicole2 nicole.probst@swisstph.ch
Source: Environmental Health Perspectives. Jun2020, Vol. 128 Issue 6, p067003-1-067003-14. 14p. 2 Diagrams, 5 Charts.
Subject Terms: *Air pollution, *Cellular immunity, *Nitrogen compounds, *Transportation, *Environmental exposure, *Particulate matter, Cell proliferation, C-reactive protein, Gene expression, Noise, Regression analysis, Research funding, Statistics, Data analysis, Body mass index, DNA methylation, Descriptive statistics, Epigenomics
Abstract: BACKGROUND: Few epigenome-wide association studies (EWAS) on air pollutants exist, and none have been done on transportation noise exposures, which also contribute to environmental burden of disease. OBJECTIVE: We performed mutually independent EWAS on transportation noise and air pollution exposures. METHODS: We used data from two time points of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) from 1,389 participants contributing 2,542 observations. We applied multiexposure linear mixed-effects regressions with participant-level random intercept to identify significant Cytosine-phosphate-Guanine (CpG) sites and differentially methylated regions (DMRs) in relation to 1-y average aircraft, railway, and road traffic day-evening-night noise (Lden); nitrogen dioxide (NO2); and particulate matter (PM) with aerodynamic diameter <2.5 lm (PM2.5). We performed candidate (CpG-based; cross-systemic phenotypes, combined into “allostatic load”) and agnostic (DMR-based) pathway enrichment tests, and replicated previously reported air pollution EWAS signals. RESULTS: We found no statistically significant CpGs at false discovery rate <0.05. However, 14, 48, 183, 8, and 71 DMRs independently associated with aircraft, railway, and road traffic Lden; NO2; and PM2.5, respectively, with minimally overlapping signals. Transportation Lden and air pollutants tendentially associated with decreased and increased methylation, respectively. We observed significant enrichment of candidate DNA methylation related to C-reactive protein and body mass index (aircraft, road traffic Lden, and PM2.5), renal function and “allostatic load” (all exposures). Agnostic functional networks related to cellular immunity, gene expression, cell growth/proliferation, cardiovascular, auditory, embryonic, and neurological systems development were enriched. We replicated increased methylation in cg08500171 (NO2) and decreased methylation in cg17629796 (PM2.5). CONCLUSIONS: Mutually independent DNA methylation was associated with source-specific transportation noise and air pollution exposures, with distinct and shared enrichments for pathways related to inflammation, cellular development, and immune responses. These findings contribute in clarifying the pathways linking these exposures and age-related diseases but need further confirmation in the context of mediation analyses. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: GreenFILE
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: 8gh
DbLabel: GreenFILE
An: 144545513
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Eze%2C+Ikenna+C%2E%22&quot;&gt;Eze, Ikenna C.&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt;&lt;i&gt; ikenna.eze@swisstph.ch&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Jeong%2C+Ayoung%22&quot;&gt;Jeong, Ayoung&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schaffner%2C+Emmanuel%22&quot;&gt;Schaffner, Emmanuel&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rezwan%2C+Faisal+I%2E%22&quot;&gt;Rezwan, Faisal I.&lt;/searchLink&gt;&lt;relatesTo&gt;3,4&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ghantous%2C+Akram%22&quot;&gt;Ghantous, Akram&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Foraster%2C+Maria%22&quot;&gt;Foraster, Maria&lt;/searchLink&gt;&lt;relatesTo&gt;1,2,6,7,8,9&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vienneau%2C+Danielle%22&quot;&gt;Vienneau, Danielle&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Kronenberg%2C+Florian%22&quot;&gt;Kronenberg, Florian&lt;/searchLink&gt;&lt;relatesTo&gt;10&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Herceg%2C+Zdenko%22&quot;&gt;Herceg, Zdenko&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vineis%2C+Paolo%22&quot;&gt;Vineis, Paolo&lt;/searchLink&gt;&lt;relatesTo&gt;11,12&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Brink%2C+Mark%22&quot;&gt;Brink, Mark&lt;/searchLink&gt;&lt;relatesTo&gt;13&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wunderli%2C+Jean-Marc%22&quot;&gt;Wunderli, Jean-Marc&lt;/searchLink&gt;&lt;relatesTo&gt;14&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schindler%2C+Christian%22&quot;&gt;Schindler, Christian&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cajochen%2C+Christian%22&quot;&gt;Cajochen, Christian&lt;/searchLink&gt;&lt;relatesTo&gt;15&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22R&#246;&#246;sli%2C+Martin%22&quot;&gt;R&#246;&#246;sli, Martin&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Holloway%2C+John+W%2E%22&quot;&gt;Holloway, John W.&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Imboden%2C+Medea%22&quot;&gt;Imboden, Medea&lt;/searchLink&gt;&lt;relatesTo&gt;1,2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Probst-Hensch1%2C+Nicole%22&quot;&gt;Probst-Hensch1, Nicole&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;i&gt; nicole.probst@swisstph.ch&lt;/i&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22Environmental+Health+Perspectives%22&quot;&gt;Environmental Health Perspectives&lt;/searchLink&gt;. Jun2020, Vol. 128 Issue 6, p067003-1-067003-14. 14p. 2 Diagrams, 5 Charts.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Air+pollution%22&quot;&gt;Air pollution&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cellular+immunity%22&quot;&gt;Cellular immunity&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Nitrogen+compounds%22&quot;&gt;Nitrogen compounds&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Transportation%22&quot;&gt;Transportation&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Environmental+exposure%22&quot;&gt;Environmental exposure&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Particulate+matter%22&quot;&gt;Particulate matter&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Cell+proliferation%22&quot;&gt;Cell proliferation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22C-reactive+protein%22&quot;&gt;C-reactive protein&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Gene+expression%22&quot;&gt;Gene expression&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Noise%22&quot;&gt;Noise&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Regression+analysis%22&quot;&gt;Regression analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Research+funding%22&quot;&gt;Research funding&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Statistics%22&quot;&gt;Statistics&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Data+analysis%22&quot;&gt;Data analysis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Body+mass+index%22&quot;&gt;Body mass index&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22DNA+methylation%22&quot;&gt;DNA methylation&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Descriptive+statistics%22&quot;&gt;Descriptive statistics&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Epigenomics%22&quot;&gt;Epigenomics&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND: Few epigenome-wide association studies (EWAS) on air pollutants exist, and none have been done on transportation noise exposures, which also contribute to environmental burden of disease. OBJECTIVE: We performed mutually independent EWAS on transportation noise and air pollution exposures. METHODS: We used data from two time points of the Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) from 1,389 participants contributing 2,542 observations. We applied multiexposure linear mixed-effects regressions with participant-level random intercept to identify significant Cytosine-phosphate-Guanine (CpG) sites and differentially methylated regions (DMRs) in relation to 1-y average aircraft, railway, and road traffic day-evening-night noise (Lden); nitrogen dioxide (NO2); and particulate matter (PM) with aerodynamic diameter &lt;2.5 lm (PM2.5). We performed candidate (CpG-based; cross-systemic phenotypes, combined into &#226;€œallostatic load&#226;€) and agnostic (DMR-based) pathway enrichment tests, and replicated previously reported air pollution EWAS signals. RESULTS: We found no statistically significant CpGs at false discovery rate &lt;0.05. However, 14, 48, 183, 8, and 71 DMRs independently associated with aircraft, railway, and road traffic Lden; NO2; and PM2.5, respectively, with minimally overlapping signals. Transportation Lden and air pollutants tendentially associated with decreased and increased methylation, respectively. We observed significant enrichment of candidate DNA methylation related to C-reactive protein and body mass index (aircraft, road traffic Lden, and PM2.5), renal function and &#226;€œallostatic load&#226;€ (all exposures). Agnostic functional networks related to cellular immunity, gene expression, cell growth/proliferation, cardiovascular, auditory, embryonic, and neurological systems development were enriched. We replicated increased methylation in cg08500171 (NO2) and decreased methylation in cg17629796 (PM2.5). CONCLUSIONS: Mutually independent DNA methylation was associated with source-specific transportation noise and air pollution exposures, with distinct and shared enrichments for pathways related to inflammation, cellular development, and immune responses. These findings contribute in clarifying the pathways linking these exposures and age-related diseases but need further confirmation in the context of mediation analyses. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=144545513
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1289/EHP6174
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 14
        StartPage: 067003-1
    Subjects:
      – SubjectFull: Air pollution
        Type: general
      – SubjectFull: Cellular immunity
        Type: general
      – SubjectFull: Nitrogen compounds
        Type: general
      – SubjectFull: Transportation
        Type: general
      – SubjectFull: Environmental exposure
        Type: general
      – SubjectFull: Particulate matter
        Type: general
      – SubjectFull: Cell proliferation
        Type: general
      – SubjectFull: C-reactive protein
        Type: general
      – SubjectFull: Gene expression
        Type: general
      – SubjectFull: Noise
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Body mass index
        Type: general
      – SubjectFull: DNA methylation
        Type: general
      – SubjectFull: Descriptive statistics
        Type: general
      – SubjectFull: Epigenomics
        Type: general
    Titles:
      – TitleFull: Genome-Wide DNA Methylation in Peripheral Blood and Long-Term Exposure to Source-Specific Transportation Noise and Air Pollution: The SAPALDIA Study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Eze, Ikenna C.
      – PersonEntity:
          Name:
            NameFull: Jeong, Ayoung
      – PersonEntity:
          Name:
            NameFull: Schaffner, Emmanuel
      – PersonEntity:
          Name:
            NameFull: Rezwan, Faisal I.
      – PersonEntity:
          Name:
            NameFull: Ghantous, Akram
      – PersonEntity:
          Name:
            NameFull: Foraster, Maria
      – PersonEntity:
          Name:
            NameFull: Vienneau, Danielle
      – PersonEntity:
          Name:
            NameFull: Kronenberg, Florian
      – PersonEntity:
          Name:
            NameFull: Herceg, Zdenko
      – PersonEntity:
          Name:
            NameFull: Vineis, Paolo
      – PersonEntity:
          Name:
            NameFull: Brink, Mark
      – PersonEntity:
          Name:
            NameFull: Wunderli, Jean-Marc
      – PersonEntity:
          Name:
            NameFull: Schindler, Christian
      – PersonEntity:
          Name:
            NameFull: Cajochen, Christian
      – PersonEntity:
          Name:
            NameFull: Röösli, Martin
      – PersonEntity:
          Name:
            NameFull: Holloway, John W.
      – PersonEntity:
          Name:
            NameFull: Imboden, Medea
      – PersonEntity:
          Name:
            NameFull: Probst-Hensch1, Nicole
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2020
              Type: published
              Y: 2020
          Identifiers:
            – Type: issn-print
              Value: 00916765
          Numbering:
            – Type: volume
              Value: 128
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Environmental Health Perspectives
              Type: main
ResultId 1