Associations of Pre- and Postnatal Air Pollution Exposures with Child Blood Pressure and Modification by Maternal Nutrition: A Prospective Study in the CANDLE Cohort.
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| Title: | Associations of Pre- and Postnatal Air Pollution Exposures with Child Blood Pressure and Modification by Maternal Nutrition: A Prospective Study in the CANDLE Cohort. |
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| Authors: | Yu Ni1 niyu@uw.edu, Szpiro, Adam A.2, Young, Michael T.3, Loftus, Christine T.3, Bush, Nicole R.4,5, LeWinn, Kaja Z.4, Sathyanarayana, Sheela3,6,7, Enquobahrie, Daniel A.1,8, Davis, Robert L.9,10, Kratz, Mario1,11, Fitzpatrick, Annette L.1,12,13, Sonney, Jennifer T.14, Tylavsky, Frances A.15, Karr, Catherine J.1,3,6 |
| Source: | Environmental Health Perspectives. Apr2021, Vol. 129 Issue 4, p047004-1-047004-12. 12p. 1 Diagram, 3 Charts, 1 Graph. |
| Subject Terms: | *Air pollution, *Particulate matter, *Nitrogen oxides, Blood pressure, Mothers, Nutrition, Cardiovascular diseases, Nutritional requirements, Research funding, Second trimester of pregnancy, Longitudinal method, Mother-child relationship, Pregnancy |
| Abstract: | BACKGROUND: Limited data suggest air pollution exposures may contribute to pediatric high blood pressure (HBP), a known predictor of adult cardiovascular diseases. METHODS: We investigated this association in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) study, a sociodemographically diverse pregnancy cohort in the southern United States with participants enrolled from 2006 to 2011. We included 822 mother–child dyads with available address histories and a valid child blood pressure measurement at 4–6 y. Systolic (SBP) and diastolic blood pressures (DBP) were converted to age-, sex-, and height-specific percentiles for normal-weight U.S. children. HBP was classified based on SBP or DBP =90th percentile. Nitrogen dioxide (NO2) and particulate matter =2.5 μm in aerodynamic diameter (PM2.5) estimates in both pre- and postnatal windows were obtained from annual national models and spatiotemporal models, respectively. We fit multivariate Linear and Poisson regressions and explored multiplicative joint effects with maternal nutrition, child sex, and maternal race using interaction terms. RESULTS: Mean PM2.5 and NO2 in the prenatal period were 10.8 [standard deviation (SD): 0.9] μm/m³ and 10.0 (SD: 2.4) ppb, respectively, and 9.9 (SD: 0.6) μmg/m³ and 8.8 (SD: 1.9) ppb from birth to the 4-y-old birthday. On average, SBP percentile increased by 14.6 (95% CI: 4.6, 24.6), and DBP percentile increased by 8.7 (95% CI: 1.4, 15.9) with each 2-μmg/m³ increase in second-trimester PM2.5. PM2.5 averaged over the prenatal period was only significantly associated with higher DBP percentiles [Β= 11.6 (95% CI: 2.9, 20.2)]. Positive associations of second-trimester PM2.5 with SBP and DBP percentiles were stronger in children with maternal folate concentrations in the lowest quartile (푝interaction = 0.05 and 0.07, respectively) and associations with DBP percentiles were stronger in female children (푝interaction = 0.05). We did not detect significant association of NO2, road proximity, and postnatal PM2.5 with any outcomes. CONCLUSIONS: The findings suggest that higher prenatal PM2.5 exposure, particularly in the second trimester, is associated with elevated early childhood blood pressure. This adverse association could be modified by pregnancy folate concentrations. [ABSTRACT FROM AUTHOR] |
| Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | GreenFILE |
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| Header | DbId: 8gh DbLabel: GreenFILE An: 150494933 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Associations of Pre- and Postnatal Air Pollution Exposures with Child Blood Pressure and Modification by Maternal Nutrition: A Prospective Study in the CANDLE Cohort. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Yu+Ni%22">Yu Ni</searchLink><relatesTo>1</relatesTo><i> niyu@uw.edu</i><br /><searchLink fieldCode="AR" term="%22Szpiro%2C+Adam+A%2E%22">Szpiro, Adam A.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Young%2C+Michael+T%2E%22">Young, Michael T.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Loftus%2C+Christine+T%2E%22">Loftus, Christine T.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Bush%2C+Nicole+R%2E%22">Bush, Nicole R.</searchLink><relatesTo>4,5</relatesTo><br /><searchLink fieldCode="AR" term="%22LeWinn%2C+Kaja+Z%2E%22">LeWinn, Kaja Z.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Sathyanarayana%2C+Sheela%22">Sathyanarayana, Sheela</searchLink><relatesTo>3,6,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Enquobahrie%2C+Daniel+A%2E%22">Enquobahrie, Daniel A.</searchLink><relatesTo>1,8</relatesTo><br /><searchLink fieldCode="AR" term="%22Davis%2C+Robert+L%2E%22">Davis, Robert L.</searchLink><relatesTo>9,10</relatesTo><br /><searchLink fieldCode="AR" term="%22Kratz%2C+Mario%22">Kratz, Mario</searchLink><relatesTo>1,11</relatesTo><br /><searchLink fieldCode="AR" term="%22Fitzpatrick%2C+Annette+L%2E%22">Fitzpatrick, Annette L.</searchLink><relatesTo>1,12,13</relatesTo><br /><searchLink fieldCode="AR" term="%22Sonney%2C+Jennifer+T%2E%22">Sonney, Jennifer T.</searchLink><relatesTo>14</relatesTo><br /><searchLink fieldCode="AR" term="%22Tylavsky%2C+Frances+A%2E%22">Tylavsky, Frances A.</searchLink><relatesTo>15</relatesTo><br /><searchLink fieldCode="AR" term="%22Karr%2C+Catherine+J%2E%22">Karr, Catherine J.</searchLink><relatesTo>1,3,6</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Apr2021, Vol. 129 Issue 4, p047004-1-047004-12. 12p. 1 Diagram, 3 Charts, 1 Graph. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Air+pollution%22">Air pollution</searchLink><br />*<searchLink fieldCode="DE" term="%22Particulate+matter%22">Particulate matter</searchLink><br />*<searchLink fieldCode="DE" term="%22Nitrogen+oxides%22">Nitrogen oxides</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+pressure%22">Blood pressure</searchLink><br /><searchLink fieldCode="DE" term="%22Mothers%22">Mothers</searchLink><br /><searchLink fieldCode="DE" term="%22Nutrition%22">Nutrition</searchLink><br /><searchLink fieldCode="DE" term="%22Cardiovascular+diseases%22">Cardiovascular diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Nutritional+requirements%22">Nutritional requirements</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Second+trimester+of+pregnancy%22">Second trimester of pregnancy</searchLink><br /><searchLink fieldCode="DE" term="%22Longitudinal+method%22">Longitudinal method</searchLink><br /><searchLink fieldCode="DE" term="%22Mother-child+relationship%22">Mother-child relationship</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy%22">Pregnancy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: BACKGROUND: Limited data suggest air pollution exposures may contribute to pediatric high blood pressure (HBP), a known predictor of adult cardiovascular diseases. METHODS: We investigated this association in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) study, a sociodemographically diverse pregnancy cohort in the southern United States with participants enrolled from 2006 to 2011. We included 822 mother–child dyads with available address histories and a valid child blood pressure measurement at 4–6 y. Systolic (SBP) and diastolic blood pressures (DBP) were converted to age-, sex-, and height-specific percentiles for normal-weight U.S. children. HBP was classified based on SBP or DBP =90th percentile. Nitrogen dioxide (NO2) and particulate matter =2.5 μm in aerodynamic diameter (PM2.5) estimates in both pre- and postnatal windows were obtained from annual national models and spatiotemporal models, respectively. We fit multivariate Linear and Poisson regressions and explored multiplicative joint effects with maternal nutrition, child sex, and maternal race using interaction terms. RESULTS: Mean PM2.5 and NO2 in the prenatal period were 10.8 [standard deviation (SD): 0.9] μm/m³ and 10.0 (SD: 2.4) ppb, respectively, and 9.9 (SD: 0.6) μmg/m³ and 8.8 (SD: 1.9) ppb from birth to the 4-y-old birthday. On average, SBP percentile increased by 14.6 (95% CI: 4.6, 24.6), and DBP percentile increased by 8.7 (95% CI: 1.4, 15.9) with each 2-μmg/m³ increase in second-trimester PM2.5. PM2.5 averaged over the prenatal period was only significantly associated with higher DBP percentiles [Β= 11.6 (95% CI: 2.9, 20.2)]. Positive associations of second-trimester PM2.5 with SBP and DBP percentiles were stronger in children with maternal folate concentrations in the lowest quartile (푝interaction = 0.05 and 0.07, respectively) and associations with DBP percentiles were stronger in female children (푝interaction = 0.05). We did not detect significant association of NO2, road proximity, and postnatal PM2.5 with any outcomes. CONCLUSIONS: The findings suggest that higher prenatal PM2.5 exposure, particularly in the second trimester, is associated with elevated early childhood blood pressure. This adverse association could be modified by pregnancy folate concentrations. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1289/EHP7486 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 047004-1 Subjects: – SubjectFull: Air pollution Type: general – SubjectFull: Particulate matter Type: general – SubjectFull: Nitrogen oxides Type: general – SubjectFull: Blood pressure Type: general – SubjectFull: Mothers Type: general – SubjectFull: Nutrition Type: general – SubjectFull: Cardiovascular diseases Type: general – SubjectFull: Nutritional requirements Type: general – SubjectFull: Research funding Type: general – SubjectFull: Second trimester of pregnancy Type: general – SubjectFull: Longitudinal method Type: general – SubjectFull: Mother-child relationship Type: general – SubjectFull: Pregnancy Type: general Titles: – TitleFull: Associations of Pre- and Postnatal Air Pollution Exposures with Child Blood Pressure and Modification by Maternal Nutrition: A Prospective Study in the CANDLE Cohort. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Yu Ni – PersonEntity: Name: NameFull: Szpiro, Adam A. – PersonEntity: Name: NameFull: Young, Michael T. – PersonEntity: Name: NameFull: Loftus, Christine T. – PersonEntity: Name: NameFull: Bush, Nicole R. – PersonEntity: Name: NameFull: LeWinn, Kaja Z. – PersonEntity: Name: NameFull: Sathyanarayana, Sheela – PersonEntity: Name: NameFull: Enquobahrie, Daniel A. – PersonEntity: Name: NameFull: Davis, Robert L. – PersonEntity: Name: NameFull: Kratz, Mario – PersonEntity: Name: NameFull: Fitzpatrick, Annette L. – PersonEntity: Name: NameFull: Sonney, Jennifer T. – PersonEntity: Name: NameFull: Tylavsky, Frances A. – PersonEntity: Name: NameFull: Karr, Catherine J. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2021 Type: published Y: 2021 Identifiers: – Type: issn-print Value: 00916765 Numbering: – Type: volume Value: 129 – Type: issue Value: 4 Titles: – TitleFull: Environmental Health Perspectives Type: main |
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