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The cytosolic sulfotransferase gene TcSULT1 is involved in deltamethrin tolerance and regulated by CncC in Tribolium castaneum.

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Title: The cytosolic sulfotransferase gene TcSULT1 is involved in deltamethrin tolerance and regulated by CncC in Tribolium castaneum.
Authors: Xu, Xin1 (AUTHOR), Meng, Xiangkun1 (AUTHOR), Zhang, Nan1 (AUTHOR), Jiang, Heng1 (AUTHOR), Ge, Huichen1 (AUTHOR), Qian, Kun1 (AUTHOR), Wang, Jianjun1,2 (AUTHOR) wangjj@yzu.edu.cn
Source: Pesticide Biochemistry & Physiology. Aug2021, Vol. 177, pN.PAG-N.PAG. 1p.
Subject Terms: *Beetles, Red flour beetle, Sulfotransferases, Deltamethrin, Silkworms, Xenobiotics
Abstract: The sulfuryl transfer reaction catalyzed by cytosolic sulfotransferase (SULT) is one of the major conjugating pathways responsible for the detoxification and subsequent elimination of xenobiotics, however, functional characterization of insect SULTs is still limited. In this study, cDNA encoding a cytosolic sulfotransferase, named TcSULT1 , was cloned from the red flour beetle, Tribolium castaneum. Sequence analysis revealed that TcSULT1 had the conserved signature sequences of SULTs, and shared moderate amino acid identities with Bombyx mori and Drosophila SULTs. Analysis of the transcription level showed that TcSULT1 was highly expressed in head, epidermis and malpighian tube, and upregulated at 4 h after exposure to deltamethrin. Knockdown of TcSULT1 significantly increased the susceptibility of beetles to deltamethrin. Both RNAi and dual-luciferase assay revealed that the transcription factor TcCncC regulates the expression of TcSULT1. These data provides insights into the function and regulatory mechanism of insect SULTs. [Display omitted] • cDNA encoding a cytosolic sulfotransferase, TcSULT1 , was cloned from Tribolium castaneum. • RNAi of TcSULT1 increased the susceptibility of T. castaneum to deltamethrin. • TcCncC upregulates the expressions of TcSULT1. [ABSTRACT FROM AUTHOR]
Copyright of Pesticide Biochemistry & Physiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: The cytosolic sulfotransferase gene TcSULT1 is involved in deltamethrin tolerance and regulated by CncC in Tribolium castaneum.
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  Label: Authors
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  Data: <searchLink fieldCode="AR" term="%22Xu%2C+Xin%22">Xu, Xin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meng%2C+Xiangkun%22">Meng, Xiangkun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Nan%22">Zhang, Nan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Heng%22">Jiang, Heng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ge%2C+Huichen%22">Ge, Huichen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qian%2C+Kun%22">Qian, Kun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jianjun%22">Wang, Jianjun</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> wangjj@yzu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Pesticide+Biochemistry+%26+Physiology%22">Pesticide Biochemistry & Physiology</searchLink>. Aug2021, Vol. 177, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Beetles%22">Beetles</searchLink><br /><searchLink fieldCode="DE" term="%22Red+flour+beetle%22">Red flour beetle</searchLink><br /><searchLink fieldCode="DE" term="%22Sulfotransferases%22">Sulfotransferases</searchLink><br /><searchLink fieldCode="DE" term="%22Deltamethrin%22">Deltamethrin</searchLink><br /><searchLink fieldCode="DE" term="%22Silkworms%22">Silkworms</searchLink><br /><searchLink fieldCode="DE" term="%22Xenobiotics%22">Xenobiotics</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The sulfuryl transfer reaction catalyzed by cytosolic sulfotransferase (SULT) is one of the major conjugating pathways responsible for the detoxification and subsequent elimination of xenobiotics, however, functional characterization of insect SULTs is still limited. In this study, cDNA encoding a cytosolic sulfotransferase, named TcSULT1 , was cloned from the red flour beetle, Tribolium castaneum. Sequence analysis revealed that TcSULT1 had the conserved signature sequences of SULTs, and shared moderate amino acid identities with Bombyx mori and Drosophila SULTs. Analysis of the transcription level showed that TcSULT1 was highly expressed in head, epidermis and malpighian tube, and upregulated at 4 h after exposure to deltamethrin. Knockdown of TcSULT1 significantly increased the susceptibility of beetles to deltamethrin. Both RNAi and dual-luciferase assay revealed that the transcription factor TcCncC regulates the expression of TcSULT1. These data provides insights into the function and regulatory mechanism of insect SULTs. [Display omitted] • cDNA encoding a cytosolic sulfotransferase, TcSULT1 , was cloned from Tribolium castaneum. • RNAi of TcSULT1 increased the susceptibility of T. castaneum to deltamethrin. • TcCncC upregulates the expressions of TcSULT1. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Pesticide Biochemistry & Physiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.pestbp.2021.104905
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      – Code: eng
        Text: English
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      – SubjectFull: Beetles
        Type: general
      – SubjectFull: Red flour beetle
        Type: general
      – SubjectFull: Sulfotransferases
        Type: general
      – SubjectFull: Deltamethrin
        Type: general
      – SubjectFull: Silkworms
        Type: general
      – SubjectFull: Xenobiotics
        Type: general
    Titles:
      – TitleFull: The cytosolic sulfotransferase gene TcSULT1 is involved in deltamethrin tolerance and regulated by CncC in Tribolium castaneum.
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            NameFull: Xu, Xin
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            NameFull: Meng, Xiangkun
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            NameFull: Zhang, Nan
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            NameFull: Jiang, Heng
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            NameFull: Ge, Huichen
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            – D: 01
              M: 08
              Text: Aug2021
              Type: published
              Y: 2021
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              Value: 00483575
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              Value: 177
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