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Knockdown or inhibition of arginine kinases enhances susceptibility of Tribolium castaneum to deltamethrin.

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Title: Knockdown or inhibition of arginine kinases enhances susceptibility of Tribolium castaneum to deltamethrin.
Authors: Zhang, Nan1 (AUTHOR), Wei, Jiaping1 (AUTHOR), Jiang, Heng1 (AUTHOR), Ge, Huichen1 (AUTHOR), Zheng, Yang1 (AUTHOR), Meng, Xiangkun1 (AUTHOR), Qian, Kun1 (AUTHOR), Wang, Jianjun1,2 (AUTHOR) wangjj@yzu.edu.cn
Source: Pesticide Biochemistry & Physiology. May2022, Vol. 183, pN.PAG-N.PAG. 1p.
Subject Terms: *Insecticides, Red flour beetle, Deltamethrin, Arginine, Kinases, Quercetin
Abstract: Metabolism of insecticides is an energy-consuming process. As an important component of the intracellular energy buffering system, arginine kinase (AK) plays an important role in insect cellular energy homeostasis and environmental stress response, but the involvement of AKs in the response to chemical stressors (insecticides) remains largely unknown. In this study, using Tribolium castaneum as a model organism, we found that deltamethrin treatment significantly upregulated the expression of TcAK1 and TcAK2 and decreased the whole body ATP content. The knockdown of TcAK1 or TcAK2 significantly enhances the deltamethrin-induced ATP depletion and increase the susceptibility of T. castaneum to deltamethrin. In addition, pretreatment with two AK inhibitors, rutin and quercetin, significantly decreased the lifespan of beetles treated with deltamethrin. These results suggest that AKs might be involved in detoxification of insecticides by regulating cellular energy balance. [Display omitted] • Exposure of Tribolium castaneum to deltamethrin led to ATP depletion and upregulation of TcAK1 and TcAK2. • RNAi of TcAK1 and TcAK2 increased the susceptibility of T. castaneum to deltamethrin. • Rutin and quercetin act as synergists to deltamethrin in T. castaneum. [ABSTRACT FROM AUTHOR]
Copyright of Pesticide Biochemistry & Physiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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Items – Name: Title
  Label: Title
  Group: Ti
  Data: Knockdown or inhibition of arginine kinases enhances susceptibility of Tribolium castaneum to deltamethrin.
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  Data: <searchLink fieldCode="AR" term="%22Zhang%2C+Nan%22">Zhang, Nan</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wei%2C+Jiaping%22">Wei, Jiaping</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Jiang%2C+Heng%22">Jiang, Heng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ge%2C+Huichen%22">Ge, Huichen</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Yang%22">Zheng, Yang</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Meng%2C+Xiangkun%22">Meng, Xiangkun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qian%2C+Kun%22">Qian, Kun</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jianjun%22">Wang, Jianjun</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> wangjj@yzu.edu.cn</i>
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  Data: <searchLink fieldCode="JN" term="%22Pesticide+Biochemistry+%26+Physiology%22">Pesticide Biochemistry & Physiology</searchLink>. May2022, Vol. 183, pN.PAG-N.PAG. 1p.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Insecticides%22">Insecticides</searchLink><br /><searchLink fieldCode="DE" term="%22Red+flour+beetle%22">Red flour beetle</searchLink><br /><searchLink fieldCode="DE" term="%22Deltamethrin%22">Deltamethrin</searchLink><br /><searchLink fieldCode="DE" term="%22Arginine%22">Arginine</searchLink><br /><searchLink fieldCode="DE" term="%22Kinases%22">Kinases</searchLink><br /><searchLink fieldCode="DE" term="%22Quercetin%22">Quercetin</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Metabolism of insecticides is an energy-consuming process. As an important component of the intracellular energy buffering system, arginine kinase (AK) plays an important role in insect cellular energy homeostasis and environmental stress response, but the involvement of AKs in the response to chemical stressors (insecticides) remains largely unknown. In this study, using Tribolium castaneum as a model organism, we found that deltamethrin treatment significantly upregulated the expression of TcAK1 and TcAK2 and decreased the whole body ATP content. The knockdown of TcAK1 or TcAK2 significantly enhances the deltamethrin-induced ATP depletion and increase the susceptibility of T. castaneum to deltamethrin. In addition, pretreatment with two AK inhibitors, rutin and quercetin, significantly decreased the lifespan of beetles treated with deltamethrin. These results suggest that AKs might be involved in detoxification of insecticides by regulating cellular energy balance. [Display omitted] • Exposure of Tribolium castaneum to deltamethrin led to ATP depletion and upregulation of TcAK1 and TcAK2. • RNAi of TcAK1 and TcAK2 increased the susceptibility of T. castaneum to deltamethrin. • Rutin and quercetin act as synergists to deltamethrin in T. castaneum. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Pesticide Biochemistry & Physiology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1016/j.pestbp.2022.105080
    Languages:
      – Code: eng
        Text: English
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        PageCount: 1
        StartPage: N.PAG
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      – SubjectFull: Insecticides
        Type: general
      – SubjectFull: Red flour beetle
        Type: general
      – SubjectFull: Deltamethrin
        Type: general
      – SubjectFull: Arginine
        Type: general
      – SubjectFull: Kinases
        Type: general
      – SubjectFull: Quercetin
        Type: general
    Titles:
      – TitleFull: Knockdown or inhibition of arginine kinases enhances susceptibility of Tribolium castaneum to deltamethrin.
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            NameFull: Zhang, Nan
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            NameFull: Wei, Jiaping
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            NameFull: Jiang, Heng
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            NameFull: Ge, Huichen
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            NameFull: Zheng, Yang
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            NameFull: Meng, Xiangkun
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            – D: 01
              M: 05
              Text: May2022
              Type: published
              Y: 2022
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              Value: 183
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            – TitleFull: Pesticide Biochemistry & Physiology
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