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Using a neonatal rat model to explore the therapeutic potential of coenzyme Q10 in prematurity under hyperoxia.

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Title: Using a neonatal rat model to explore the therapeutic potential of coenzyme Q10 in prematurity under hyperoxia.
Authors: Lee, Cheng‐Han1 (AUTHOR), Lee, Ming‐Sheng1 (AUTHOR), Yang, Rei‐Cheng1,2 (AUTHOR), Hsu, Chien‐Sheng1 (AUTHOR), Su, Tzu‐Cheng3 (AUTHOR), Chang, Po‐Sheng4,5 (AUTHOR), Lin, Ping‐Ting4,6 (AUTHOR) apt810@csmu.edu.tw, Kao, Jun‐Kai1,7,8,9 (AUTHOR) 96777@cch.org.tw
Source: Environmental Toxicology. Jun2022, Vol. 37 Issue 6, p1472-1482. 11p.
Subject Terms: Ubiquinones, Hematopoietic growth factors, Oxidative stress, Animal disease models, Hyperoxia, Free radical scavengers, Laboratory rats
Abstract: Hyperoxia, is often used in preterm supportive care, leading to high oxygen exposure in neonates. Coenzyme Q10 (CoQ10) is a free radical scavenger that has been studied in older children but never be investigated for its role in preterm care. We hypothesize that the administration of exogenous CoQ10 would raise serum concentrations of CoQ10 and mitigate the adverse effects of hyperoxia on the organs by reducing oxygen‐free radicals and inflammation. The aim of this study was to evaluate the effects of oxidative stress, inflammatory response, and survival in neonatal rats after CoQ10 treatment. Neonatal rats delivered from four pregnant Wistar rats were randomly divided into four groups: (a) control, (b) CoQ10, (c) hyperoxia (O2 group), and (d) treatment (CoQ10 + O2) groups. The dose of CoQ10 injected was 30 mg/kg. The CoQ9, CoQ10, cytokines, oxidative stress, and antioxidant enzyme activity were measured. Tissue samples were histologically examined and mortality was monitored for 16 days. The level of CoQ9 significantly increased in the liver, kidney, and plasma, while the level of CoQ10 significantly increased in most organ tissues in the CoQ10 + O2 group. Additionally, CoQ10 decrease oxidative stress in the liver, increase antioxidant enzyme activity in the heart, kidney, and brain, and reverse an inclined level of hematopoietic growth factors. However, CoQ10 had no effect on inflammation, organ damage, or mortality. Therefore, the use of CoQ10 in potential adjuvant therapy for neonatal hyperoxia requires further research. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Toxicology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Using a neonatal rat model to explore the therapeutic potential of coenzyme Q10 in prematurity under hyperoxia.
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  Data: <searchLink fieldCode="AR" term="%22Lee%2C+Cheng‐Han%22">Lee, Cheng‐Han</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lee%2C+Ming‐Sheng%22">Lee, Ming‐Sheng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Rei‐Cheng%22">Yang, Rei‐Cheng</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hsu%2C+Chien‐Sheng%22">Hsu, Chien‐Sheng</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Su%2C+Tzu‐Cheng%22">Su, Tzu‐Cheng</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chang%2C+Po‐Sheng%22">Chang, Po‐Sheng</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lin%2C+Ping‐Ting%22">Lin, Ping‐Ting</searchLink><relatesTo>4,6</relatesTo> (AUTHOR)<i> apt810@csmu.edu.tw</i><br /><searchLink fieldCode="AR" term="%22Kao%2C+Jun‐Kai%22">Kao, Jun‐Kai</searchLink><relatesTo>1,7,8,9</relatesTo> (AUTHOR)<i> 96777@cch.org.tw</i>
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  Data: <searchLink fieldCode="JN" term="%22Environmental+Toxicology%22">Environmental Toxicology</searchLink>. Jun2022, Vol. 37 Issue 6, p1472-1482. 11p.
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  Data: <searchLink fieldCode="DE" term="%22Ubiquinones%22">Ubiquinones</searchLink><br /><searchLink fieldCode="DE" term="%22Hematopoietic+growth+factors%22">Hematopoietic growth factors</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+disease+models%22">Animal disease models</searchLink><br /><searchLink fieldCode="DE" term="%22Hyperoxia%22">Hyperoxia</searchLink><br /><searchLink fieldCode="DE" term="%22Free+radical+scavengers%22">Free radical scavengers</searchLink><br /><searchLink fieldCode="DE" term="%22Laboratory+rats%22">Laboratory rats</searchLink>
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  Data: Hyperoxia, is often used in preterm supportive care, leading to high oxygen exposure in neonates. Coenzyme Q10 (CoQ10) is a free radical scavenger that has been studied in older children but never be investigated for its role in preterm care. We hypothesize that the administration of exogenous CoQ10 would raise serum concentrations of CoQ10 and mitigate the adverse effects of hyperoxia on the organs by reducing oxygen‐free radicals and inflammation. The aim of this study was to evaluate the effects of oxidative stress, inflammatory response, and survival in neonatal rats after CoQ10 treatment. Neonatal rats delivered from four pregnant Wistar rats were randomly divided into four groups: (a) control, (b) CoQ10, (c) hyperoxia (O2 group), and (d) treatment (CoQ10 + O2) groups. The dose of CoQ10 injected was 30 mg/kg. The CoQ9, CoQ10, cytokines, oxidative stress, and antioxidant enzyme activity were measured. Tissue samples were histologically examined and mortality was monitored for 16 days. The level of CoQ9 significantly increased in the liver, kidney, and plasma, while the level of CoQ10 significantly increased in most organ tissues in the CoQ10 + O2 group. Additionally, CoQ10 decrease oxidative stress in the liver, increase antioxidant enzyme activity in the heart, kidney, and brain, and reverse an inclined level of hematopoietic growth factors. However, CoQ10 had no effect on inflammation, organ damage, or mortality. Therefore, the use of CoQ10 in potential adjuvant therapy for neonatal hyperoxia requires further research. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Environmental Toxicology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1002/tox.23499
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      – Code: eng
        Text: English
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        PageCount: 11
        StartPage: 1472
    Subjects:
      – SubjectFull: Ubiquinones
        Type: general
      – SubjectFull: Hematopoietic growth factors
        Type: general
      – SubjectFull: Oxidative stress
        Type: general
      – SubjectFull: Animal disease models
        Type: general
      – SubjectFull: Hyperoxia
        Type: general
      – SubjectFull: Free radical scavengers
        Type: general
      – SubjectFull: Laboratory rats
        Type: general
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      – TitleFull: Using a neonatal rat model to explore the therapeutic potential of coenzyme Q10 in prematurity under hyperoxia.
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            NameFull: Lee, Cheng‐Han
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            NameFull: Hsu, Chien‐Sheng
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            – D: 01
              M: 06
              Text: Jun2022
              Type: published
              Y: 2022
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