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Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime.

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Title: Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime.
Authors: Alvarez, Julio (AUTHOR), Nielsen, Søren Saxmose (AUTHOR), Robardet, Emmanuelle (AUTHOR), Stegeman, Arjan (AUTHOR), Van Gucht, Steven (AUTHOR), Vuta, Vlad (AUTHOR), Antoniou, Sotiria‐Eleni (AUTHOR), Aznar, Inma (AUTHOR), Papanikolaou, Alexandra (AUTHOR), Roberts, Helen Clare (AUTHOR)
Source: EFSA Journal. Jun2022, Vol. 20 Issue 6, p1-78. 78p.
Subject Terms: *Animal laws, Rabies, Dogs, Volumetric analysis, Antibody titer, Disease incidence, Animal welfare laws
Company/Entity: European Commission , European Food Safety Authority
Abstract: EFSA received a mandate from the European Commission to assess the risks related to a possible reduction of the waiting period after rabies antibody titration test to 30 days compared with 90 days of the current EU legislation, for dogs moving from certain non‐EU countries to the EU. This Scientific Report assessed the probability of introduction of rabies into the EU through commercial and non‐commercial movements of vaccinated dogs with a positive titration test (≥ 0.5 IU/mL) if the waiting period decreases from 90 to 30 days. Assuming that all the legal requirements are complied with, the risk of transmission of rabies through the movement of a vaccinated dog is related to the risk of introducing an animal incubating rabies that was infected before the day of vaccination or shortly after vaccination but before the development of immunity (21 days post‐vaccination). Using published data on the incubation period for experimental and field cases in dogs and considering the rabies incidence data in certain countries, the aggregated probability for the annual introduction of rabies through dogs was assessed. Considering the uncertainty related to the duration of the incubation period, the number of imported dogs, and the disease incidence in some countries it was concluded with a 95% certainty that the maximum number of rabies‐infected imported dogs complying with the regulations in a 20‐year period could increase from 5 to 20 when decreasing the waiting period from 90 to 30 days. Nevertheless, the potential impact of even a small increase in probability means the risk is increased for a region like the EU where rabies has long been a focus for eradication, to protect human and animal health. [ABSTRACT FROM AUTHOR]
Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Risks related to a possible reduction of the waiting period for dogs after rabies antibody titration to 30 days compared with 90 days of the current EU legislative regime.
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  Data: <searchLink fieldCode="AR" term="%22Alvarez%2C+Julio%22">Alvarez, Julio</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Nielsen%2C+Søren+Saxmose%22">Nielsen, Søren Saxmose</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Robardet%2C+Emmanuelle%22">Robardet, Emmanuelle</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Stegeman%2C+Arjan%22">Stegeman, Arjan</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Van+Gucht%2C+Steven%22">Van Gucht, Steven</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vuta%2C+Vlad%22">Vuta, Vlad</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Antoniou%2C+Sotiria‐Eleni%22">Antoniou, Sotiria‐Eleni</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aznar%2C+Inma%22">Aznar, Inma</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Papanikolaou%2C+Alexandra%22">Papanikolaou, Alexandra</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Roberts%2C+Helen+Clare%22">Roberts, Helen Clare</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22EFSA+Journal%22">EFSA Journal</searchLink>. Jun2022, Vol. 20 Issue 6, p1-78. 78p.
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  Data: *<searchLink fieldCode="DE" term="%22Animal+laws%22">Animal laws</searchLink><br /><searchLink fieldCode="DE" term="%22Rabies%22">Rabies</searchLink><br /><searchLink fieldCode="DE" term="%22Dogs%22">Dogs</searchLink><br /><searchLink fieldCode="DE" term="%22Volumetric+analysis%22">Volumetric analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Antibody+titer%22">Antibody titer</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+incidence%22">Disease incidence</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+welfare+laws%22">Animal welfare laws</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22European+Commission%22">European Commission</searchLink> <br /><searchLink fieldCode="DE" term="%22European+Food+Safety+Authority%22">European Food Safety Authority</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: EFSA received a mandate from the European Commission to assess the risks related to a possible reduction of the waiting period after rabies antibody titration test to 30 days compared with 90 days of the current EU legislation, for dogs moving from certain non‐EU countries to the EU. This Scientific Report assessed the probability of introduction of rabies into the EU through commercial and non‐commercial movements of vaccinated dogs with a positive titration test (≥ 0.5 IU/mL) if the waiting period decreases from 90 to 30 days. Assuming that all the legal requirements are complied with, the risk of transmission of rabies through the movement of a vaccinated dog is related to the risk of introducing an animal incubating rabies that was infected before the day of vaccination or shortly after vaccination but before the development of immunity (21 days post‐vaccination). Using published data on the incubation period for experimental and field cases in dogs and considering the rabies incidence data in certain countries, the aggregated probability for the annual introduction of rabies through dogs was assessed. Considering the uncertainty related to the duration of the incubation period, the number of imported dogs, and the disease incidence in some countries it was concluded with a 95% certainty that the maximum number of rabies‐infected imported dogs complying with the regulations in a 20‐year period could increase from 5 to 20 when decreasing the waiting period from 90 to 30 days. Nevertheless, the potential impact of even a small increase in probability means the risk is increased for a region like the EU where rabies has long been a focus for eradication, to protect human and animal health. [ABSTRACT FROM AUTHOR]
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  Label:
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  Data: <i>Copyright of EFSA Journal is the property of European Food Safety Authority and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.2903/j.efsa.2022.7350
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        Text: English
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        Type: general
      – SubjectFull: Rabies
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      – SubjectFull: Dogs
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      – SubjectFull: Volumetric analysis
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      – SubjectFull: Antibody titer
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              Text: Jun2022
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