View in EDS HTML Full Text PDF Full Text

Associations of Pre- and Postnatal Air Pollution Exposures with Child Behavioral Problems and Cognitive Performance: A U.S. Multi-Cohort Study.

Saved in:
Bibliographic Details
Title: Associations of Pre- and Postnatal Air Pollution Exposures with Child Behavioral Problems and Cognitive Performance: A U.S. Multi-Cohort Study.
Authors: Yu Ni1 niyu@uw.edu, Loftus, Christine T.1, Szpiro, Adam A.2, Young, Michael T.1, Hazlehurst, Marnie F.1, Murphy, Laura E.3, Tylavsky, Frances A.4, Mason, W. Alex4, LeWinn, Kaja Z.5, Sathyanarayana, Sheela1,6,7, Barrett, Emily S.8, Bush, Nicole R.5,9, Karr, Catherine J.1,6,10
Source: Environmental Health Perspectives. Jun2022, Vol. 130 Issue 6, p067008-1-067008-15. 15p. 1 Diagram, 4 Charts, 2 Graphs.
Subject Terms: *Air pollution, *Particulate matter, *Nitrogen oxides, *Environmental exposure, Statistics, Confidence intervals, Multivariate analysis, Research methodology, Regression analysis, Prenatal exposure delayed effects, Behavior disorders in children, Risk assessment, Child Behavior Checklist, Research funding, Cognitive testing, Data analysis software, Data analysis, Children, Pregnancy
Abstract: BACKGROUND: Population studies support the adverse associations of air pollution exposures with child behavioral functioning and cognitive performance, but few studies have used spatiotemporally resolved pollutant assessments. OBJECTIVES: We investigated these associations using more refined exposure assessments in 1,967 mother–child dyads from three U.S. pregnancy cohorts in six cities in the ECHO-PATHWAYS Consortium. METHODS: Pre- and postnatal nitrogen dioxide (NO2) and particulate matter (PM) ≤2.5 µm in aerodynamic diameter (PM2.5) exposures were derived from an advanced spatiotemporal model. Child behavior was reported as Total Problems raw score using the Child Behavior Checklist at age 4–6 y. Child cognition was assessed using cohort-specific cognitive performance scales and quantified as the Full-Scale Intelligence Quotient (IQ). We fitted multivariate linear regression models that were adjusted for sociodemographic, behavioral, and psychological factors to estimate associations per 2- unit increase in pollutant in each exposure window and examined modification by child sex. Identified critical windows were further verified by distributed lag models (DLMs). RESULTS: Mean NO2 and PM2.5 ranged from 8.4 to 9.0 ppb and 8.4 to 9.1 µg/m³, respectively, across pre- and postnatal windows. Average child Total Problems score and IQ were 22.7 [standard deviation (SD): 18.5] and 102.6 (SD: 15.3), respectively. Children with higher prenatal NO2 exposures were likely to have more behavioral problems [b: 1.24; 95% confidence interval (CI): 0.39, 2.08; per 2 ppb NO2], particularly NO2 in the first and second trimester. Each 2-µg/m³ increase in PM2.5 at age 2–4 y was associated with a 3.59 unit (95% CI: 0.35, 6.84) higher Total Problems score and a 2.63 point (95% CI: -5.08, -0.17) lower IQ. The associations between PM2.5 and Total Problems score were generally stronger in girls. Most predefined windows identified were not confirmed by DLMs. DISCUSSION: Our study extends earlier findings that have raised concerns about impaired behavioral functioning and cognitive performance in children exposed to NO2 and PM2.5 in utero and in early life. [ABSTRACT FROM AUTHOR]
Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: GreenFILE
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: 8gh
DbLabel: GreenFILE
An: 157788890
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Associations of Pre- and Postnatal Air Pollution Exposures with Child Behavioral Problems and Cognitive Performance: A U.S. Multi-Cohort Study.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Yu+Ni%22">Yu Ni</searchLink><relatesTo>1</relatesTo><i> niyu@uw.edu</i><br /><searchLink fieldCode="AR" term="%22Loftus%2C+Christine+T%2E%22">Loftus, Christine T.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Szpiro%2C+Adam+A%2E%22">Szpiro, Adam A.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Young%2C+Michael+T%2E%22">Young, Michael T.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Hazlehurst%2C+Marnie+F%2E%22">Hazlehurst, Marnie F.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Murphy%2C+Laura+E%2E%22">Murphy, Laura E.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Tylavsky%2C+Frances+A%2E%22">Tylavsky, Frances A.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Mason%2C+W%2E+Alex%22">Mason, W. Alex</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22LeWinn%2C+Kaja+Z%2E%22">LeWinn, Kaja Z.</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Sathyanarayana%2C+Sheela%22">Sathyanarayana, Sheela</searchLink><relatesTo>1,6,7</relatesTo><br /><searchLink fieldCode="AR" term="%22Barrett%2C+Emily+S%2E%22">Barrett, Emily S.</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Bush%2C+Nicole+R%2E%22">Bush, Nicole R.</searchLink><relatesTo>5,9</relatesTo><br /><searchLink fieldCode="AR" term="%22Karr%2C+Catherine+J%2E%22">Karr, Catherine J.</searchLink><relatesTo>1,6,10</relatesTo>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Environmental+Health+Perspectives%22">Environmental Health Perspectives</searchLink>. Jun2022, Vol. 130 Issue 6, p067008-1-067008-15. 15p. 1 Diagram, 4 Charts, 2 Graphs.
– Name: Subject
  Label: Subject Terms
  Group: Su
  Data: *<searchLink fieldCode="DE" term="%22Air+pollution%22">Air pollution</searchLink><br />*<searchLink fieldCode="DE" term="%22Particulate+matter%22">Particulate matter</searchLink><br />*<searchLink fieldCode="DE" term="%22Nitrogen+oxides%22">Nitrogen oxides</searchLink><br />*<searchLink fieldCode="DE" term="%22Environmental+exposure%22">Environmental exposure</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Multivariate+analysis%22">Multivariate analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Research+methodology%22">Research methodology</searchLink><br /><searchLink fieldCode="DE" term="%22Regression+analysis%22">Regression analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Prenatal+exposure+delayed+effects%22">Prenatal exposure delayed effects</searchLink><br /><searchLink fieldCode="DE" term="%22Behavior+disorders+in+children%22">Behavior disorders in children</searchLink><br /><searchLink fieldCode="DE" term="%22Risk+assessment%22">Risk assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Child+Behavior+Checklist%22">Child Behavior Checklist</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+testing%22">Cognitive testing</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22Pregnancy%22">Pregnancy</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: BACKGROUND: Population studies support the adverse associations of air pollution exposures with child behavioral functioning and cognitive performance, but few studies have used spatiotemporally resolved pollutant assessments. OBJECTIVES: We investigated these associations using more refined exposure assessments in 1,967 mother–child dyads from three U.S. pregnancy cohorts in six cities in the ECHO-PATHWAYS Consortium. METHODS: Pre- and postnatal nitrogen dioxide (NO2) and particulate matter (PM) ≤2.5 µm in aerodynamic diameter (PM2.5) exposures were derived from an advanced spatiotemporal model. Child behavior was reported as Total Problems raw score using the Child Behavior Checklist at age 4–6 y. Child cognition was assessed using cohort-specific cognitive performance scales and quantified as the Full-Scale Intelligence Quotient (IQ). We fitted multivariate linear regression models that were adjusted for sociodemographic, behavioral, and psychological factors to estimate associations per 2- unit increase in pollutant in each exposure window and examined modification by child sex. Identified critical windows were further verified by distributed lag models (DLMs). RESULTS: Mean NO2 and PM2.5 ranged from 8.4 to 9.0 ppb and 8.4 to 9.1 µg/m³, respectively, across pre- and postnatal windows. Average child Total Problems score and IQ were 22.7 [standard deviation (SD): 18.5] and 102.6 (SD: 15.3), respectively. Children with higher prenatal NO2 exposures were likely to have more behavioral problems [b: 1.24; 95% confidence interval (CI): 0.39, 2.08; per 2 ppb NO2], particularly NO2 in the first and second trimester. Each 2-µg/m³ increase in PM2.5 at age 2–4 y was associated with a 3.59 unit (95% CI: 0.35, 6.84) higher Total Problems score and a 2.63 point (95% CI: -5.08, -0.17) lower IQ. The associations between PM2.5 and Total Problems score were generally stronger in girls. Most predefined windows identified were not confirmed by DLMs. DISCUSSION: Our study extends earlier findings that have raised concerns about impaired behavioral functioning and cognitive performance in children exposed to NO2 and PM2.5 in utero and in early life. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Environmental Health Perspectives is the property of National Institute of Environmental Health Sciences and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=8gh&AN=157788890
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1289/ehp10248
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 15
        StartPage: 067008-1
    Subjects:
      – SubjectFull: Air pollution
        Type: general
      – SubjectFull: Particulate matter
        Type: general
      – SubjectFull: Nitrogen oxides
        Type: general
      – SubjectFull: Environmental exposure
        Type: general
      – SubjectFull: Statistics
        Type: general
      – SubjectFull: Confidence intervals
        Type: general
      – SubjectFull: Multivariate analysis
        Type: general
      – SubjectFull: Research methodology
        Type: general
      – SubjectFull: Regression analysis
        Type: general
      – SubjectFull: Prenatal exposure delayed effects
        Type: general
      – SubjectFull: Behavior disorders in children
        Type: general
      – SubjectFull: Risk assessment
        Type: general
      – SubjectFull: Child Behavior Checklist
        Type: general
      – SubjectFull: Research funding
        Type: general
      – SubjectFull: Cognitive testing
        Type: general
      – SubjectFull: Data analysis software
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: Pregnancy
        Type: general
    Titles:
      – TitleFull: Associations of Pre- and Postnatal Air Pollution Exposures with Child Behavioral Problems and Cognitive Performance: A U.S. Multi-Cohort Study.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yu Ni
      – PersonEntity:
          Name:
            NameFull: Loftus, Christine T.
      – PersonEntity:
          Name:
            NameFull: Szpiro, Adam A.
      – PersonEntity:
          Name:
            NameFull: Young, Michael T.
      – PersonEntity:
          Name:
            NameFull: Hazlehurst, Marnie F.
      – PersonEntity:
          Name:
            NameFull: Murphy, Laura E.
      – PersonEntity:
          Name:
            NameFull: Tylavsky, Frances A.
      – PersonEntity:
          Name:
            NameFull: Mason, W. Alex
      – PersonEntity:
          Name:
            NameFull: LeWinn, Kaja Z.
      – PersonEntity:
          Name:
            NameFull: Sathyanarayana, Sheela
      – PersonEntity:
          Name:
            NameFull: Barrett, Emily S.
      – PersonEntity:
          Name:
            NameFull: Bush, Nicole R.
      – PersonEntity:
          Name:
            NameFull: Karr, Catherine J.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 06
              Text: Jun2022
              Type: published
              Y: 2022
          Identifiers:
            – Type: issn-print
              Value: 00916765
          Numbering:
            – Type: volume
              Value: 130
            – Type: issue
              Value: 6
          Titles:
            – TitleFull: Environmental Health Perspectives
              Type: main
ResultId 1